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Enteric coated preparation of Clarithromycin

A technology of enteric-coated preparations and clarithromycin, which is applied in the field of clarithromycin enteric-coated preparations and its preparation, can solve the problems of low bioavailability, achieve the effects of reducing damage, improving bioavailability, and reducing adverse reactions

Inactive Publication Date: 2006-04-19
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there are no reports in the literature of clarithromycin enteric-coated preparations that do not dissolve and release under acidic conditions but only dissolve and release under alkaline conditions, and that the bioavailability is not low.

Method used

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  • Enteric coated preparation of Clarithromycin
  • Enteric coated preparation of Clarithromycin
  • Enteric coated preparation of Clarithromycin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Enteric-coated tablets using clarithromycin as raw material

[0041]

[0042] Weigh clarithromycin, lactose, microcrystalline cellulose, 1 / 2 amount of crospovidone, croscarmellose sodium, hydroxypropyl cellulose, 1 / 2 amount through a 80-mesh sieve according to the prescription amount sodium carboxymethyl starch, after mixing evenly, add an appropriate amount of 10% povidone aqueous solution, granulate, and dry the dry granules with 1 / 2 amount of crospovidone and 1 / 2 amount of sodium carboxymethyl starch, Silicon dioxide and magnesium stearate are mixed evenly, the content is measured, and the determined amount is pressed into tablets with a tablet machine.

[0043] The prepared tablet cores are weighed and placed in a coating pan, and coated with a coating solution to obtain enteric-coated tablets.

Embodiment 2

[0044] Example 2: Enteric-coated tablets using clarithromycin as raw material

[0045]

[0046] Concrete preparation method is with embodiment 1.

Embodiment 3

[0047] Example 3: Enteric-coated tablets using clarithromycin salt as raw material

[0048]

[0049] Sodium dodecyl sulfate

[0050] Concrete preparation method is with embodiment 1.

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Abstract

An entenic clamycin and its preparing process are disclosed. Said enteric clamycin contains one or more units and each unit is composed of a core prepared from clamycin and one or more medicinal excipients and an enteric polymer film coated on the surface of said core.

Description

technical field [0001] The invention relates to a clarithromycin enteric-coated preparation and a preparation method thereof. technical background [0002] The antibacterial mechanism of clarithromycin is to act on the ribosome 50S subunit in the bacterial 70S system, hindering the synthesis of bacterial proteins, and is a long-term antibacterial agent. It has inhibitory effect on Gram-positive bacteria such as Staphylococcus aureus, Streptococcus, Pneumococcus, etc., and some Gram-negative bacteria such as Haemophilus influenzae, Bordetella pertussis, Neisseria gonorrhoeae, Legionella pneumophila and some anaerobic bacteria Bacteroides such as Bacteroides fragilis, Peptostreptococcus, Propionibacterium acnes, etc. also have inhibitory effects, and also have inhibitory effects on Mycoplasma. The characteristic of this product is that its antibacterial activity in vitro is similar to that of erythromycin, but its antibacterial activity against some bacteria such as Staphyloc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P31/04
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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