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Eye gel or in-situ gel and preparation method thereof

A kind of ophthalmic gel and gel technology, which is applied in the direction of pharmaceutical formula, medical raw materials derived from molluscs, drug delivery, etc., can solve the problems of environmental protection pollution, environmental ecological damage, and many operation links, and achieve high surface activity, The effect of prolonged absorption time and simple process

Inactive Publication Date: 2006-04-26
朱样根 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing technology in chemical method hydrolysis extraction process is: 1, extract nacre powder hydrolyzate with hydrochloric acid extraction or alkali extraction or acid and alkali exchange etc., above extraction process exists than extracting with purified water: (1) cost height, operation There are many links; (2) acid or alkali is used in the extraction, and acid and alkali are exchanged for extraction several times, which can easily cause personal injury; (3) from the aspect of environmental protection, it will seriously pollute the environment and damage the ecology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 350g of pearl layer powder, add 6 times of purified water to decoct for 1-4 days, stir 1-4 times every 0.5h-2h during the decoction process, fully stir and filter, and the filtrate is concentrated to 6:1-3: 1. Let cool and filter for later use. Take another appropriate amount of water for injection, heat to dissolve 0.1-3.6g of borax and 0.2-18.6g of boric acid, then add 0.1-4.8g of sodium chloride in sequence, heat and stir to dissolve, add 0.01-3.0g of parabens and the above pearls while hot Layer powder extract 1-350ml, stir well, heat to 40-120°C and keep warm for 10-50 minutes, add glycerin to dissolve, cool, add water to the specified amount; 0.01-0.43g borneol, add ethanol 0.01-3ml to dissolve, stir Slowly add to the above solution, stir well, and filter; cool the filtrate to 1°C-10°C, take 0.01-200g of poloxamer, slowly add to the above cooling filtrate under stirring, mix well, and let it stand for 10- After 50 minutes, stir evenly, and finally add water ...

Embodiment 2

[0019] Take 320g of pearl layer powder, add 6 times of purified water to decoct for 1-3 days, stir 1-3 times every 0.5h-2h during the decoction process, fully stir and filter, and the filtrate is concentrated to 5:1-3: 1. Let cool and filter for later use. Take another appropriate amount of water for injection, heat to dissolve 0.1-3.6g of borax and 0.2-18.6g of boric acid, then add 0.1-4.7g of sodium chloride in sequence, heat and stir to dissolve, add 0.01-3.8ml of phenoxyethanol and the above nacre while hot Powder extract 1-360ml, stir well, heat to 40-120°C and keep warm for 10-50 minutes, add glycerin to dissolve, cool, add water to the specified amount; 0.01-0.5g borneol, add ethanol 0.01-3.3ml to dissolve, stir Slowly add to the above solution, stir well, filter; cool the filtrate to 1°C-10°C, take carbomer 0.01-150g, slowly add to the above cooling filtrate under stirring, mix well, and let stand for 10-40 Minutes, stir well, finally add water for injection to make 1...

Embodiment 3

[0021] Take 330g of pearl layer powder, add 4.3 times of purified water to decoct for 2-4 days, stir 2-4 times every 0.5h-3h during the decoction process, fully stir and filter, and the filtrate is concentrated to 5:1-3.3: 1. Let cool and filter for later use. Take another appropriate amount of water for injection, heat to dissolve 0.1-3.9g of borax and 0.2-19.1g of boric acid, then add 0.1-4.7g of sodium chloride in sequence, heat and stir to dissolve, add 0.01-4.8ml of phenoxyethanol and the above nacre while hot Powder extract 10-500ml, stir well, heat to 40-120°C and keep warm for 10-50 minutes, add glycerin to dissolve, cool, add water to the specified amount; borneol 0.01-0.5g, add ethanol 0.01-3.7ml to dissolve, stir Slowly add to the above solution, stir well, and filter; cool the filtrate to 1°C-10°C, take 0.01-120g of polyvinyl alcohol, slowly add it to the above cooling filtrate under stirring, mix well, and let stand for 10-40 Minutes, stir well, finally add water...

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PUM

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Abstract

The invention relates to an eye gel or in-situ gel and preparation method, comprising base compositions and auxiliary materials, wherein the base compositions include pearl powder extract, borneo camphor, tinkalite, boric acid, ethanol, gel base and glycerine, the auxiliary materials include osmoregulation agent and bacteriostatic agent.

Description

technical field [0001] The invention relates to an ophthalmic gel or an in-body gel and a preparation method thereof. Background technique [0002] At present, there is an ophthalmic preparation for the prevention and treatment of juvenile pseudomyopia, eye dryness, astringency and visual fatigue caused by excessive eye use and dry climate. The preparation contains nacre powder hydrolyzate, borneol, trace element zinc and other active ingredients, wherein the nacre powder hydrolyzate is hydrolyzed and extracted by a chemical method. [0003] Existing technology in the chemical method hydrolysis extraction process is: 1, extract nacre powder hydrolyzate with hydrochloric acid extraction or alkali extraction or acid and alkali exchange etc., above extraction process exists than extracting with purified water: (1) cost height, operation There are many links; (2) use acid or alkali, acid and alkali to exchange and extract several times in the extraction, which can easily cause ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/045A61K33/22A61K35/618A61P27/02A61P27/10
Inventor 朱样根辛继跃徐立新徐文英黄志元
Owner 朱样根
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