Composite three-dimensional porous bone tissue engineering scaffold material and its preparation method

A technology for bone tissue engineering and scaffold materials, which is applied in bone implants, medical science, prostheses, etc., can solve the problem of not being able to prepare non-water-soluble composite three-dimensional porous bone tissue engineering scaffold materials, and achieve good mechanical properties, Simple process and uniform effect

Inactive Publication Date: 2006-07-12
JINAN UNIVERSITY
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current composite method cannot prepare water-insoluble composite three-dimensional porou

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Example 1

[0027] Put the powdery raw materials in a cube-shaped container; place the container in the reactor of the supercritical carbon dioxide equipment, seal it, and press the -1℃ carbon dioxide into the reactor through the liquid pump; increase the pressure in the reactor to reach 7.31MPa, raise the temperature in the reactor to 65°C; after 30 minutes, the exhaust will release the pressure, and the exhaust rate will be 0.1MPa / min, so that the pressure in the reactor will drop to atmospheric pressure; the composition of the raw materials is as follows: 30 grams of polylactic acid , 70 grams of freeze-dried human bone matrix powder. The obtained three-dimensional porous bone tissue engineering scaffold material is evenly composited, and its compressive strength is 1.24Mpa. The composite material is implanted into the rat femoral muscle bag for animal experiments. After four weeks, it can be seen that it is wrapped by muscle tissue, and the mesenchyme is along the pore ...

Example Embodiment

[0028] Example 2

[0029] Put the powdered raw materials in a disc-shaped container; place the container in the reactor of the supercritical carbon dioxide equipment, seal, and press the carbon dioxide at -5°C into the reactor through the liquid pump; increase the pressure in the reactor to reach 30MPa, the temperature in the reactor was increased to 32°C; after 120 minutes, the exhaust gas released the pressure, and the exhaust rate was 10MPa / min, so that the pressure in the reactor was reduced to atmospheric pressure; the composition of the raw materials was as follows: 100 grams of polylactic acid. The obtained three-dimensional porous bone tissue engineering scaffold material has a compressive strength of 5.92Mpa. The animal experiment results show that the shape of the muscle tissue around the implanted material is normal, there is no obvious inflammatory reaction, and it has good biocompatibility.

Example Embodiment

[0030] Example 3

[0031] Put the powdered raw materials in a hemispherical container; place the container in the reactor of the supercritical carbon dioxide equipment, seal it, and press the -10℃ carbon dioxide into the reactor through a liquid pump; increase the pressure in the reactor to 8.56 MPa, the temperature in the reactor is increased to 60°C; after 40 minutes, the pressure is naturally released to reduce the pressure in the reactor to atmospheric pressure; the composition of the raw materials is as follows: 30 grams of polylactic acid and 70 grams of animal bone matrix freeze-dried powder. The obtained three-dimensional porous bone tissue engineering scaffold material has a uniform composite, and its compressive strength is 1.19Mpa. After implantation in the rat femoral muscle pocket, it can be observed that the implant material and the muscle tissue have a good contact interface, without obvious fiber wrapping, and no obvious Inflammation, with good biocompatibility.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Login to view more

Abstract

The invention discloses a composite three-dimensional porous bone tissue engineering cradle material and the preparing method, for the purpose of providing a composite three-dimensional porous bone tissue engineering cradle material with good mechanical property and a preparing method under low temperature and without using organic solvent. The material is prepared by employing polylactic acid (PLA), human bone matrix, animal bone matrix, bone matrix gelatin and fully decalcified bone as raw material, and the preparing method comprises loading the raw material into vessel for hypercritical treatment, pressurizing and heating, and pressure releasing. The material prepared in this invention can be widely used in bone tissue engineering field.

Description

technical field [0001] The invention relates to a composite three-dimensional porous bone tissue engineering support material. [0002] The invention also relates to a preparation method of a composite three-dimensional porous bone tissue engineering scaffold material. Background technique [0003] Commonly used bone tissue engineering scaffold materials mainly include artificial synthetic materials, natural derived materials and composite materials. Synthetic and naturally derived materials each have advantages and disadvantages, with limited bone-forming abilities alone. In order to enhance the osteogenic and bone-inducing abilities of materials, research on composite materials has gradually emerged in recent years. [0004] At present, the commonly used composite methods at home and abroad include solution casting method, molding method, and particle leaching method. These methods all require the use of organic solvents, but organic solvents are usually difficult to rem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/40A61F2/28
Inventor 周长忍李茜茜
Owner JINAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap