Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composite three-dimensional porous bone tissue engineering scaffold material and its preparation method

A technology for bone tissue engineering and scaffold materials, which is applied in bone implants, medical science, prostheses, etc., can solve the problem of not being able to prepare non-water-soluble composite three-dimensional porous bone tissue engineering scaffold materials, and achieve good mechanical properties, Simple process and uniform effect

Inactive Publication Date: 2006-07-12
JINAN UNIVERSITY
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current composite method cannot prepare water-insoluble composite three-dimensional porous bone tissue engineering scaffold materials at low temperature and avoid the use of organic solvents

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Put the powdered raw material in a cube-shaped container; place the container in the reactor of supercritical carbon dioxide equipment, seal it, and press the carbon dioxide at -1°C into the reactor through a liquid pump; increase the pressure in the reactor to 7.31MPa, raise the temperature in the reactor to 65°C; after 30 minutes, release the pressure by exhausting, and the exhaust rate is 0.1MPa / min, so that the pressure in the reactor is reduced to atmospheric pressure; the raw material composition is as follows: 30 grams of polylactic acid , human bone matrix freeze-dried powder 70 grams. The obtained three-dimensional porous bone tissue engineering scaffold material is evenly composited, and the compressive strength is 1.24Mpa. The composite material is implanted into the femoral muscle bag of rats for animal experiments. The implant material grows in, without obvious fiber wrapping, no obvious inflammatory reaction, and has good biocompatibility.

Embodiment 2

[0029] Put the powdery raw material in a circular sheet-shaped container; place the container in the reactor of supercritical carbon dioxide equipment, seal it, and press carbon dioxide at -5°C into the reactor through a liquid pump; increase the pressure in the reactor to 30MPa, raise the temperature in the reactor to 32°C; after 120 minutes, release the pressure with exhaust at a rate of 10MPa / min to reduce the pressure in the reactor to atmospheric pressure; the composition of the raw materials is as follows: 100 grams of polylactic acid. The obtained three-dimensional porous bone tissue engineering scaffold material has a compressive strength of 5.92Mpa. The results of animal experiments show that the shape of the muscle tissue around the implanted material is normal, there is no obvious inflammatory reaction, and it has good biocompatibility.

Embodiment 3

[0031] Put the powdered raw material in a hemispherical container; place the container in the reactor of supercritical carbon dioxide equipment, seal it, and press carbon dioxide at -10°C into the reactor through a liquid pump; increase the pressure in the reactor to 8.56 MPa, raise the temperature in the reactor to 60°C; after 40 minutes, release the pressure naturally to reduce the pressure in the reactor to atmospheric pressure; the composition of the raw materials is as follows: 30 grams of polylactic acid, 70 grams of animal bone matrix freeze-dried powder. The obtained three-dimensional porous bone tissue engineering scaffold material is evenly compounded, and its compressive strength is 1.19Mpa. After implanting into the rat femoral muscle bag, it can be observed that the implanted material has a good contact interface with the muscle tissue, no obvious fiber wrapping, no obvious Inflammatory response, good biocompatibility.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a composite three-dimensional porous bone tissue engineering cradle material and the preparing method, for the purpose of providing a composite three-dimensional porous bone tissue engineering cradle material with good mechanical property and a preparing method under low temperature and without using organic solvent. The material is prepared by employing polylactic acid (PLA), human bone matrix, animal bone matrix, bone matrix gelatin and fully decalcified bone as raw material, and the preparing method comprises loading the raw material into vessel for hypercritical treatment, pressurizing and heating, and pressure releasing. The material prepared in this invention can be widely used in bone tissue engineering field.

Description

technical field [0001] The invention relates to a composite three-dimensional porous bone tissue engineering support material. [0002] The invention also relates to a preparation method of a composite three-dimensional porous bone tissue engineering scaffold material. Background technique [0003] Commonly used bone tissue engineering scaffold materials mainly include artificial synthetic materials, natural derived materials and composite materials. Synthetic and naturally derived materials each have advantages and disadvantages, with limited bone-forming abilities alone. In order to enhance the osteogenic and bone-inducing abilities of materials, research on composite materials has gradually emerged in recent years. [0004] At present, the commonly used composite methods at home and abroad include solution casting method, molding method, and particle leaching method. These methods all require the use of organic solvents, but organic solvents are usually difficult to rem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/40A61F2/28
Inventor 周长忍李茜茜
Owner JINAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com