Regulator of cannabinoid receptor

A technology of cannabinoid receptors and modulators, applied in antiviral agents, digestive system, metabolic diseases, etc.
CN1816536AInactive Publication Date: 2006-08-09TAKEDA PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TAKEDA PHARMA CO LTD
Publication Date
2006-08-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

A cannabinoid receptor modulator which contains a compound represented by the formula (I0): (I0) (wherein X represents oxygen, etc.; R0 represents optionally substituted acylamino; ring A0 represents a benzene ring optionally having a substituent besides R0; and ring B represents optionally substituted five-membered heterocycle), a salt of the compound, or a prodrug of either.
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Description

technical field

[0001] The present invention relates to benzene ring-fused 5-membered heterocyclic compounds, especially benzofuran derivatives, as cannabinoid receptor modulators, and pharmaceutical compositions comprising these compounds. Background technique

[0002] Cannabinoid receptors are G-protein coupled receptors with seven transmembrane domains. Among them, the CB1 receptor is mainly distributed in the central nervous system, and its existence is known from Devane W A et al. (Molecular Pharmacology, 34, 605-613 (1988)). The CB2 receptor, which has a predominantly cellular distribution in the immune system as well as peripheral tissues, was discovered by Munro S et al. (Nature, 365, 61-65 (1993)). CB1 receptor and CB2 receptor show 48% homology. 97-99% of the amino acid sequence of the CB1 receptor is maintained in rat, mouse and human.

[0003] In the brain, CB1 receptors are found mainly in the hippocampus, striatum, substantia nigra, basal forebrain regions, ...

Claims

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