Production of L-aspartase calcium

Abstract

Production of L-aspartyl-calcium is carried out by taking L-asparagic acid and calcium hydroxide as raw materials, furnishing in proportion 3.4-3.8:1, putting it into mixer, adding into water while agitating to obtain soliquoid, heating the soliquoid, inducing into colloid mill and high-pressure fluid nanometer mill to obtain L-aspartyl-calcium liquid, inducing L-aspartyl-calcium into agitating container, adding into 45% alcohol, agitating, laying aside to obtain L-aspartyl-calcium crystal, adding into 55% alcohol, agitating, laying aside, centrifugal separation depositing, vacuum drying deposit and screening to obtain final product. It has short reactive time, higher purity and more yields.

Description

technical field

[0001] The invention relates to a preparation method of L-aspartic acid chelated calcium, which belongs to the technical field of synthesis methods of pharmaceutical intermediates, food additives and calcium supplements. Background technique

[0002] Calcium ion is one of the most abundant inorganic ions. Under normal circumstances, the total amount of calcium in the adult body is about 1200 grams, of which about 99% is concentrated in bones and teeth, and the remaining 1% is often present in the extracellular fluid, blood and soft tissues in the form of free or combined ions. Since adults generally need 300-600mg of calcium per day for supplementation, calcium must be taken in from food.

[0003] Calcium ions play an important role in the normal beating of the heart, the coagulation of blood, the normal excitatory conduction of muscles and nerves, the maintenance of appropriate induction, the permeability of cell membranes, and the activation of many enzyme...