Production of L-aspartase calcium

Abstract

Production of L-aspartyl-calcium is carried out by taking L-asparagic acid and calcium hydroxide as raw materials, furnishing in proportion 3.4-3.8:1, putting it into mixer, adding into water while agitating to obtain soliquoid, heating the soliquoid, inducing into colloid mill and high-pressure fluid nanometer mill to obtain L-aspartyl-calcium liquid, inducing L-aspartyl-calcium into agitating container, adding into 45% alcohol, agitating, laying aside to obtain L-aspartyl-calcium crystal, adding into 55% alcohol, agitating, laying aside, centrifugal separation depositing, vacuum drying deposit and screening to obtain final product. It has short reactive time, higher purity and more yields.

Description

technical field [0001] The invention relates to a preparation method of L-aspartic acid chelated calcium, which belongs to the technical field of synthesis methods of pharmaceutical intermediates, food additives and calcium supplements. Background technique [0002] Calcium ion is one of the most abundant inorganic ions. Under normal circumstances, the total amount of calcium in the adult body is about 1200 grams, of which about 99% is concentrated in bones and teeth, and the remaining 1% is often present in the extracellular fluid, blood and soft tissues in the form of free or combined ions. Since adults generally need 300-600mg of calcium per day for supplementation, calcium must be taken in from food. [0003] Calcium ions play an important role in the normal beating of the heart, the coagulation of blood, the normal excitatory conduction of muscles and nerves, the maintenance of appropriate induction, the permeability of cell membranes, and the activation of many enzyme...

AI Technical Summary

Problems solved by technology

The disadvantages are that the process flow is long, the degree of scale is not high, and the purity and yield of the finished product are low.

[0007] Chinese Patent Publication No. CN1587257A has introduced the preparation method of amino acid chelated calcium and special equipment thereof, and this method also aims at overcoming above-mentioned preparation time long, yield low, existing in amino acid chelated calcium with chemical method. Inability to realize large-scale industrial production, low chelation rate, incomplete reaction, and low solubility in water, which affect human absorption (paragraph 2, page 2 of the instructions)

The applicant believes that because this method introduces the mixed solution obtained in the first step into the high-pressure fluid nanomill after the second step of additional mixing, since the temperature of the mixed solution has not changed, it is impossible to ensure that the materials fully react and improve the chelation. Therefore, the purity and yield of the obtained product will be affected; in addition, the process of this method is cumbersome, and the use and equipment are redundant.

[0008] CN1467198A relates to a kind of L-aspartic acid chelated zinc, only recommends the new molecular structure of L-aspartic acid chelated zinc, does not mention the preparation method, according to the hint of this patent specification, the preparation method adopts the authorized announcement The preparation method of the amino acid metal chelate of No. CN1069096C, but the front process of this method still shows as pure traditional chemical method, the reaction time is lengthy, it is difficult to be applicable to suitability for industrialized production, although used and ethanol purification crystallization in the follow-up step

[0009] CN1613861A has introduced L-aspartic acid chelated chromium and its preparation method, the reaction time of this method coexisting with CN1069096 is long, the details in the technical process are loaded down with trivial details, is unfavorable for industrialized production