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Preparation method of anti-inflammation analgesia medicine compound bone peptide injection

A compound osteopeptide, anti-inflammatory and analgesic technology, which is used in the preparation of anti-inflammatory and analgesic drug compound osteopeptide injection, and the field of compound osteopeptide small-volume injection finished products, can solve the problem of decreased content, strong irritation of the liquid, and no impurities. Completely remove etc.

Inactive Publication Date: 2006-09-13
巴里莫尔制药(通化)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound osteopeptide injection in the domestic market is produced by many companies, all of which are prepared by traditional techniques. The existing products have poor quality stability, strong irritation of the liquid, high failure rate of clarity, and drop in pH value. Problems such as content decline, color deepening, and unstable curative effect cannot be solved
The main reason is that some impurities are not completely removed during the preparation process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1) Preparation of bone peptide extract:

[0035] A) Take clean and crushed fetal bovine limb bones, add 1 times the amount of water for injection, 2.0kg / cm 2 Decoct under pressure twice, 2 hours each time, combine the decoction liquid, refrigerate at -5°C for 12 hours, remove the upper layer of fat, adjust the pH value to 7.8, heat to 85°C, keep warm for 30 minutes, and refrigerate at -5°C for 24 hours. Impurities were removed by centrifugation, the centrifugation condition was 4000 rpm, and the centrifugation time was 30 minutes to obtain a supernatant.

[0036] B) Adjust the pH value of the supernatant to 3.8, heat to 95°C, incubate for 20 minutes, refrigerate at -1°C for 18 hours, and centrifuge at 4000 rpm for 10 minutes to adjust the pH value of the supernatant 6.7, heated to 75°C, incubated for 20 minutes, refrigerated at -1°C for 18 hours, centrifuged at 4000 rpm for 15 minutes to obtain a supernatant.

[0037] C) The supernatant is ultrafiltered with an ultraf...

Embodiment 2

[0043] 1) Preparation of bone peptide extract:

[0044] A) Take clean and crushed fetal bovine limb bones, add 2 times the amount of water for injection, 1.5kg / cm 2 Decoct twice under pressure, 1 hour each time, combine the decoction liquid, refrigerate at -8°C for 24 hours, remove the upper layer of fat, adjust the pH value to 8.0, heat to 70°C, keep warm for 20 minutes, and refrigerate at -2°C for 18 hours. Impurities were removed by centrifugation, the centrifugation condition was 4000 rpm, and the centrifugation time was 15 minutes to obtain a supernatant.

[0045] B) Adjust the pH value of the supernatant to 3.5, heat it to 75°C, keep it warm for 15 minutes, refrigerate at -4°C for 24 hours, and centrifuge at 4000 rpm for 30 minutes to adjust the pH value of the supernatant 6.8, heated to 85°C, incubated for 15 minutes, refrigerated at -5°C for 24 hours, centrifuged at 4000 rpm for 30 minutes to obtain a supernatant.

[0046] C) The supernatant is ultrafiltered with an ...

Embodiment 3

[0051] 1) Preparation of bone peptide extract:

[0052] A) Take clean and crushed fetal bovine limb bones, add 1.5 times the amount of water for injection, 2.5kg / cm 2 Decoct under pressure twice, 2 hours each time, combine the decoction liquid, refrigerate at -10°C for 18 hours, remove the upper layer of fat, adjust the pH value to 7.5, heat to 80°C, keep warm for 25 minutes, and refrigerate at -8°C for 24 hours. Impurities were removed by centrifugation, the centrifugation condition was 4000 rpm, and the centrifugation time was 20 minutes to obtain a supernatant.

[0053] B) Adjust the pH value of the supernatant to 4.0, heat to 85°C, incubate for 25 minutes, refrigerate at -10°C for 24 hours, and centrifuge at 4000 rpm for 15 minutes to adjust the pH value of the supernatant 6.5, heated to 95°C, incubated for 25 minutes, refrigerated at -10°C for 12 hours, centrifuged at 4000 rpm for 10 minutes to obtain a supernatant.

[0054] C) The supernatant is ultrafiltered with an u...

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PUM

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Abstract

A compound bone peptide injection for treating rheumatic and rheumatoid arthritides, bone fracture, osteoporosis, cervical spondylopathy is prepared from scorpion and the limb bone of young ox through high-temp and-pressure extracting, depositing in alcohol and then in acid, heat treating, cold storage, ultrafiltration, further preparing, pouring in containers in N2 atmosphere, sterilizing and lamp examining.

Description

technical field [0001] The invention relates to a preparation method of compound osteopeptide injection, an anti-inflammatory and analgesic drug. Specifically, it relates to a small-capacity injection mainly composed of bone peptide extract and scorpion extract. The scorpion and fetal bovine limb bones are respectively extracted by hot pressing, and subjected to alkali precipitation, acid precipitation, heat treatment, refrigeration and Ultrafiltration technology treatment, final preparation, filling with nitrogen, sterilization, lamp inspection and packaging to make a finished compound bone peptide small-capacity injection, which belongs to the field of chemical preparations. This product contains a variety of bone growth factors, which can regulate bone metabolism and growth, participate in the absorption and release of bone calcium, and promote the formation of callus and new blood vessels. Scorpion peptide has anti-inflammatory and analgesic effects. This product has anti...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61P29/00A61P19/08
Inventor 郭智华
Owner 巴里莫尔制药(通化)有限公司
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