Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Freeze-drying powder injection containing red-rooted salvia safflower

A technology of freeze-dried powder injection and red jelly, which is applied in the field of medicinal powder injection, can solve the problems of unclear active ingredients, affecting the effectiveness and safety of Danhong injection, and the comprehensive curative effect is not obvious, so as to improve hemodynamics The effect of science, easy quality control, and high comprehensive curative effect

Inactive Publication Date: 2006-09-27
云南一尧科技开发有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although salvia miltiorrhiza and safflower have a certain therapeutic effect on cardiovascular and cerebrovascular diseases, their comprehensive curative effect is not obvious and needs to be further improved
For example, the Danhong injection developed in the 1980s, due to the constraints of the conditions at that time, had the problem of unclear active ingredients in Danhong injection, especially the active ingredients Danshensu, caffeoyl ester, safflower pigment, etc. Chemically active ingredients that are easily oxidized and hydrolyzed are easily oxidized and hydrolyzed in aqueous solution, thereby affecting the quality of Danhong Injection and the effectiveness and safety of clinical use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of Salvia miltiorrhiza extract: take 1 kg of salvia miltiorrhiza, soak in 8 kg of 85% ethanol for 24 hours, grind, filter, then soak twice with 8 kg of 80% and 70% ethanol, each time for 12 hours, combine the soaking liquid, filter , decolorized with 0.4% activated carbon, passed through a 80-140 mesh 2cm-thick short silica gel column, concentrated under reduced pressure at 25-50mmHg to a specific gravity of 1.15-1.25, and freeze-dried to obtain 0.002 kg of active ingredients containing 48.2 % more than Danshen extract.

[0042] Safflower pigment: can be purchased from specialized manufacturers.

Embodiment 2

[0044] Danhong freeze-dried powder injection, formula:

[0045] Danshen Extract 125g

[0046] Saffron 75g

[0047] Mannitol 100g

[0048] Process: Under the condition of 10,000 grades, dissolve the above ingredients together in water for injection, after decolorization, add water for injection to dilute to the required volume of 2000ml, filter, and filter the filtrate through filter paper and 0.4μm filter membrane. , under the condition of grade 100, filter with a filter membrane below 0.2 μm, send the fine filtrate into the sub-packer, pack in 2ml per tube, cover with a slotted cover, and send it to a freeze-vacuum dryer, and quickly cool to -38 ℃~-40℃, 2-3 hours, gradually and slowly raise the temperature to 35℃~45℃ (about 10 hours), plug the lid tightly, take out the product, tie the cover, pack, inspect and pass, and make 1000 pieces of 200mg specifications Danhong freeze-dried powder injection.

Embodiment 3

[0050] Danhong freeze-dried powder injection formula:

[0051] Danshen Extract 100g

[0052] Safflower pigment 100g

[0053] Amino Acid 150g

[0054] Using the process provided in Example 2, 1000 Danhong freeze-dried powder injections with a specification of 200 mg were prepared.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The red sage-safflower freeze dried powder for injection consists of red sage-safflower extract 15-75 wt% and injection supplementary material 25-85 wt%, and the red sage-safflower extract consists of red sage extract 5-95 wt% and safflower extract 5-95 wt%. The red sage-safflower freeze dried powder for injection has the effects of red sage in improving blood circulation, lowering the blood viscosity and reducing blood fat and the effects of safflower in promoting blood circulation, dredging meridian, dispersing blood clots and relieving pain synthesized, clear ingredients, reasonable recipe, controlled quality and greatly raised stability. It is one ideal medicine for treating cardiac and cerebral vascular diseases.

Description

technical field [0001] The invention relates to a biologically active medicinal powder injection made from salvia miltiorrhiza and safflower extracts. Background technique [0002] The dry roots and rhizomes of Salvia miltiorrhiza Bge., a plant of the Labiatae family, are mainly used to treat blood stasis and relieve pain, promote blood circulation and stimulate menstruation, clear heart and eliminate troubles. The hemodynamics of blood circulation, reducing blood viscosity, lowering blood lipids, etc., so it is a commonly used Chinese herbal medicine among the people. In the past, the Danshen extract was only a fat-soluble component - tanshinone, which failed to fully represent the efficacy of Danshen, especially in promoting blood circulation and removing stasis. Although the Danshen injection made from it has been continuously extracted and removed, there is no index tracking , the loss of active ingredients is more serious. Safflower is the dried flower of Carthamus ti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/19A61P3/06
Inventor 任杨帆
Owner 云南一尧科技开发有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products