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Micropore bone cement and bone cream

A technology of bone cement and microporous bone, used in medical science, tissue regeneration, prosthesis, etc., can solve the problems of loose prosthesis, inability to repair bone defects, normal bone necrosis, etc., and reduce the phenomenon of normal bone necrosis. , Reduce loosening and repair, and ensure the effect of stable combination

Inactive Publication Date: 2006-09-27
北京茵普兰科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The replaced prosthesis works well at first, but long-term clinical follow-up shows that the prosthesis will loosen over time, which is due to the detachment of the interface between the bone cement and the bone body. Within 10-20 years after the operation, a considerable number of patients need to perform revision surgery, that is, to re-implant the prosthesis
In addition, the curing temperature of the bone cement during the operation is as high as 90°C, which can easily lead to the necrosis of the normal bone body connected with the prosthesis
[0003] In addition, the bone plaster currently popular on the market has low mechanical strength and cannot be used for repairing bone defects in the weight-bearing parts of the human body.

Method used

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  • Micropore bone cement and bone cream
  • Micropore bone cement and bone cream
  • Micropore bone cement and bone cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] [Example 1] Preparation of microporous bone cement

[0044] After mixing 88 g of polymethyl methacrylate, 2 g of benzoyl peroxide and 10 g of barium sulfate, they are sterilized to make 100 g of ordinary bone cement powder; take 49 ml of methyl methacrylate, N,N-dimethyl terephthalate After mixing 1 ml of amine, hydroquinone is added to make an ordinary bone cement liquid, where the concentration of hydroquinone in the bone cement solution is 100 mg per kilogram. Take 40g of ordinary bone cement powder and 20ml of ordinary bone cement liquid, and pack them separately after disinfection to obtain ordinary bone cement.

[0045] After mixing 2g of gypsum, 2g of calcium phosphate and 1g of sodium chloride, they are disinfected to make modifier powder; mix the modifier powder with 4ml of distilled water to make a slurry modifier for later use;

[0046] Take 22.5g of slurry-like ordinary bone cement and mix with the above-mentioned slurry-like modifier and stir at high speed for ...

Embodiment 2

[0049] [Example 2] Preparation of bone paste

[0050] Mix 4 g of gypsum, 4 g of nano-hydroxyapatite and 1 g of sodium chloride to prepare modifier powder; mix the modifier powder with 8 ml of water to prepare a slurry modifier for later use; Ordinary bone cement is prepared by the method; 15g of slurry-like ordinary bone cement and the above-mentioned slurry-like modifier are mixed and stirred at high speed for about 1-1.5 minutes, and the bone paste product can be obtained after mixing and stirring uniformly.

[0051] Put the above-mentioned bone paste into a syringe and inject it into a ∮8×17mm plastic tube. After 15-18 minutes (room temperature 18°C), it will harden, and the hardening temperature will be less than 50°C. Then, grind into a cylinder of ∮8×16mm to make 6 samples. Then put the samples on the pressure testing machine, the head speed is 0.5mm / min, and the compression data of 3mm and 5mm are taken respectively to generate the pressure yield curve, determine the failur...

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Abstract

The porous bone cement of the present invention consists of bone cement in 1 weight portions and modifier in 0.2-0.7 weight portions mixed together, and its modifier consists of binder 30-50 weight portions, promoter 30-50 weight portions and pore creating agent 10-30 weight portions. The bone paste of the present invention consists of bone cement in 1 weight portions and modifier in 0.7-1.3 weight portions mixed together, and its modifier consists of binder 30-50 weight portions, promoter 30-50 weight portions and pore creating agent 10-30 weight portions. The bone cement of the present invention has mechanical strength similar to that of common bone cement, close cementation between prosthesis and diaphysis, and low curing temperature. The bone paste of the present invention has relatively high mechanical strength and is suitable for repair of serious bone defect and tooth.

Description

Technical field [0001] The present invention relates to the field of orthopedics, in particular to a microporous bone cement and bone paste. Background technique [0002] The bone cement invented in the 1960s is one of the major achievements of orthopedics. The bone cement can fill the interface between the bone of the human body and the prosthesis, so that the prosthesis is bonded to the bone of the human body through the bone cement, so as to achieve the purpose of replacing the damaged joints in the human body. The replaced prosthesis works very well initially, but long-term clinical follow-ups have shown that over time, the prosthesis will loosen. This is due to the separation of the interface between the bone cement and the bone. Therefore, it is generally Within 10-20 years after surgery, a considerable number of patients need to undergo repair surgery, that is, re-implant prosthesis. In addition, the curing temperature of the bone cement during surgery is as high as 90°C, ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/56
CPCA61L2430/02
Inventor 周袭明
Owner 北京茵普兰科技发展有限公司
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