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Method for extracting dihydro-quercetin from larch

A technology of dihydroquercetin and larch, applied in the direction of organic chemistry, etc., can solve the problems of affecting product yield, large amount of precipitant, etc., and achieve the effects of good stability, high solvent flash point and good safety.

Inactive Publication Date: 2006-10-11
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the purity of dihydroquercetin can be greater than 97% in the resulting product, this method seriously affects the productive rate of the product because its precipitant usage is too large (1000 times that of the product amount), and only 0.29% can be obtained. The yield; in addition, the key technical content in the process flow, that is, the precipitant used has not been disclosed

Method used

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  • Method for extracting dihydro-quercetin from larch
  • Method for extracting dihydro-quercetin from larch
  • Method for extracting dihydro-quercetin from larch

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Take 1 kg of Xiaoxinganling larch sawdust from 0.0m to 1.5m above the ground and place it in a stainless steel container with a volume of 40L, add 10L of water (10 times of water), soak for 40 minutes at 85°C, and centrifuge to obtain 0.21% bismuth Add 8.4L of hydrogen quercetin primary extract (extract I) to extract I; then add 8.5L of water to the residue, soak for 30 minutes at 87°C, and centrifuge to obtain 0.045% dihydroquercetin The secondary extraction solution (extraction solution II) 9.0L is used as the soaking solution of new larch chips next time. At 45°C, 1.2 L of methyl tert-butyl ether was added to the primary extract, stirred for 30 minutes, and left still for 30 minutes to separate the organic phase to obtain 1.13 L of methyl tert-butyl ether extract. Then add 10 g of activated carbon to the organic phase and stir for decolorization for 30 minutes, filter and put it in a rotary evaporator, and remove the solvent under vacuum (0.015 MPa) with an initial t...

Embodiment 2

[0035] Take the Daxinganling larch tree section of 0.0m~1.5m tree section above the ground and break it into debris with an average particle size of 3×3×3mm, take 1kg of debris and place it in a stainless steel container with a volume of 40L, add Example 1 Soak 9.0L of the secondary extract in 82°C for 30 minutes to obtain 7.8L of primary extract; add 9.0L of water to the filter residue for secondary extraction, and filter to obtain 9.0L of secondary extract, which will be used as the next new Infusion of larch chips.

[0036] Add 1.5 L of methyl tert-butyl ether to the above primary extract at 42°C, stir for 20 minutes, let stand for 20 minutes, and separate the organic phase to obtain 1.41 L of methyl tert-butyl ether extract. Add 10g activated carbon in the organic phase and stir and decolorize for 30 minutes, add the organic phase filtrate after filtration in the rotary evaporator, and under vacuum (0.015MPa) the initial temperature is 40°C, and the final temperature is 85...

Embodiment 3

[0039] Take 1 kg of Daxinganling larch shavings from 0.0m to 1.5m above the ground, add 6.0L of the secondary extract in Example 2, soak for 60 minutes at 90°C, and centrifuge to obtain 5.3L of the primary extract; 6.0L of water is used for secondary extraction to obtain 5.9L of secondary extraction solution, which is used as the soaking solution of new larch chips next time.

[0040] Add 0.6 L of methyl tert-butyl ether to the primary extract at 40°C, stir for 15 minutes, let stand for 20 minutes, and separate 0.56 L of methyl tert-butyl ether ether extract; add 30 g of activated carbon and stir for 30 minutes to decolorize, filter .

[0041] The filtrate is under vacuum (0.015MPa), the initial temperature is 50 ℃, and the solvent is removed under the condition of final temperature 70 ℃ to obtain 58.5 g of paste, add 1.5L of 70 ℃ water to the paste, stir for 10 minutes, the temperature was lowered to 8° C., and the filtered cake was dried at room temperature to obtain 22.1 g...

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Abstract

The invention provides a method of extracting dihydroquercetin from eastern larch, this method using water as extractant, extracting xingan eastern larch contains dihydroquercetin, liquid-liquid extracting the produced aquosity extract, adsorption decolouring methyl tert-butyl ether tobacco extract by activated char or active clay, stripping the dissolvant of decolourized methyl tert-butyl ether tobacco extract in vaccum, the grease thing of water stripped is crystallization purified by water and getting rude product of dihydroquercetin. According to need, the getted rude product of dihydroquercetin can be recrystallization purified by water and getting elaboration product of dihydroquercetin. The method of this invention has prominant technique effect, not only the yield is as high as 1.69%-2.0%, but also the getted rude product of dihydroquercetin's purity is as high as 95%-96%, the purified elaboration product of dihydroquercetin can reach the purity of 99%.

Description

technical field [0001] The invention relates to extracting dihydroquercetin from plants, in particular to extracting dihydroquercetin from larch. Background technique [0002] Dihydroquercetin (Dihydroquercetin; 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-benzopyran-4-one), chemical formula: C 15 h 12 o 7 , the structural formula is as follows: [0003] [0004] Dihydroquercetin is one of the bioflavonoids and is a powerful antioxidant. It can be used industrially as an anti-shock agent and stabilizer for engine raw materials and jet raw materials. It can also be widely used as a food preservative. It can be used in medicine to increase the activity of red blood cells to delay the aging of the body. The Russian Pharmacopoeia in 2003 introduced that dihydroquercetin has a good effect on human circulatory system diseases, ischemic heart disease, ischemic arteriosclerosis, liver activity disorders, eye diseases, diabetes, and prevention and treatment of tumor...

Claims

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Application Information

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IPC IPC(8): C07C311/32
Inventor 王正平刘莹
Owner GUANGZHOU UNIVERSITY
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