Beta-elemene derivatives containing nitrogen and their preparation method and use

A derivative, the technology of elemene, which is applied in the field of application of nitrogen-containing derivatives of β-elemene, can solve the problems of weak anticancer effect, insignificant curative effect, poor stability, etc.
CN1844105AInactive Publication Date: 2006-10-11SHENYANG PHARMA UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2006-10-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an A-elemene nitrogenous derivant, it providing the preparation and usage of A-elemene nitrogenous derivant, the structural formula is as picture shows, wherein R represent aliphatic amido of C1-C20, aromatic amido; amido of C1-C20 containing heterocycle; wherein cyclohexane skeleton has three chirality center. This derivant may has some physiologically active like alkaloid; meanwhile, it can increase polarity and making the synthesized derivant has certain alkalinity and it can reach the purpose of improving water-solubility salt-forming with inorganic acid or organic acid.
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Description

Technical field:

[0001] The present invention relates to new β-elemene nitrogen-containing derivatives and a preparation method thereof, to an intermediate for synthesizing said β-elemene nitrogen-containing derivatives and a preparation method thereof, and to said β-elemene nitrogen-containing derivatives Application of nitrogen derivatives. Background technique:

[0002] The β-elemene (I) isolated from the volatile oil of Curcuma wenyujin Y.H.Chen et C.Ling (Curcuma wenyujin Y.H.Chen et C.Ling), also known as Wenzezhu, is a broad-spectrum anti-tumor drug elemene milk developed by my country. (Guo Yongming, Wu Xiuying, Chen Yuren. Isolation and identification of elemene in the volatile oil of Ezhu [J]. Chinese Medicine Bulletin, 1983, 8(30): 31-33.) β-elemene has a relatively strong effect on tumor cells High selectivity, no bone marrow suppression, no obvious liver and kidney toxicity, has dual effects of selectively inhibiting tumor cell proliferation and improving immune ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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