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Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect

A technology of photodynamic therapy and vascular imaging, which is applied in the field of medicine and medical equipment, can solve the problems of low resolution, low sensitivity of pure optical imaging, and inability to realize vascular damage, etc., and achieves the effect of low cost and easy application and promotion

Inactive Publication Date: 2006-10-18
SOUTH CHINA NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional optical microscopy technology can observe the blood vessels around the tumor, but tissue slices are required, and the carrier cannot detect the damage of blood vessels in real time; the use of laser imaging technology can study the blood flow velocity distribution, perfusion rate and other hemodynamic changes
However, since tissue is a turbid medium, strong scattering of light will result in low sensitivity and low resolution of purely optical imaging

Method used

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  • Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect
  • Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect
  • Photoacoustic blood vessel imaging method and equipment for monitoring photodynamic tumor treating effect

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Effect test

Embodiment 1

[0040] Depend on figure 1It can be seen that the device of the present invention is composed of a laser generating component 1 , a rotating scanning component 2 , an acoustic signal collecting component 3 , a computer component 4 , a sample fixing component 5 , and an acoustic coupling component 6 . Among them, the laser component 1 is composed of a laser 1-1, a coated mirror 1-2, a concave lens 1-3, and a ground glass 1-4 connected in sequence; the rotary scanning component is composed of a computer 4 through a digital I / O card and a relay controller 2- 2. Control the stepping motor 2-1 to drive the rotating bracket 2-3 to rotate. The sound signal acquisition component is amplified by the sound detector 3-1 through the signal amplifier 3-2, averaged by the oscilloscope 3-3, and collected by the computer 4 with a GPIB card through the control software. Among them: laser 1-1 is TII from Belarusian LOTIS company, which can emit continuously adjustable wavelengths of 350-500nm, ...

Embodiment 2

[0046] The device used in this embodiment is the same as in Embodiment 1. The above-mentioned device is applied to the study of the photodynamic damage effect of different blood vessel diameters, light doses and photosensitizer concentrations on blood vessels. In the test, the diameter is 80 μm left and right and diameter 284 μm The data of blood vessels after photodynamic analysis were analyzed, and the damage to blood vessels is shown in Figure 4(a) and (b) respectively. Wherein, when Protoporphyrin IX concentration is 40 μmol / L , the light dose is 36J / cm 2 、72J / cm 2 When the diameter is 80 μm The left and right blood vessels were almost completely destroyed. Diameter 284 μm Due to its thicker wall, the blood vessels are affected by small doses (20 μmol / L Protoporphyrin IX has little effect, all more than 50% of the initial value, and more recovery after 24h, large dose (40 μmol / L ) Protoporphyrin IX has damage to blood vessels, but the damage is still much smaller ...

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Abstract

The present invention relates to real-time monitoring of photodynamic tumor treating effect, and the photoacoustic blood vessel imaging method is that during laser irradiation of tumor tissue for photodynamic treatment, the photoacoustic chromatographic images of the tumor tissue before and after photodynamic action are compared and the blood vessel diameter change is reflected with the positive and negative peak-to-peak width of the photoacoustic blood vessel signals. The equipment for the real-time monitoring of photodynamic tumor treating effect includes laser generator assembly, acoustic signal acquiring assembly and computer successively connected electrically, as well as rotating scan mechanism connected electrically to the computer, sample fixing assembly and connected acoustic assembly. The present invention is sensitive and quick in real-time monitoring of photodynamic tumor treating effect.

Description

technical field [0001] The present invention relates to medicine and medical devices. In more detail, a method of photoacoustic angiography to monitor the effect of photodynamic therapy on tumors. [0002] The invention also relates to a device for carrying out the above-mentioned method. Background technique [0003] Photodynamic therapy is the least invasive treatment for early malignant tumors and a palliative treatment for advanced malignant tumors. Photodynamic therapy can selectively destroy local superficial tumors without endangering normal tissues, and can be performed in conjunction with chemotherapy and radiotherapy. Since the survival and growth of tumor cells mainly depend on the nutrients provided by blood vessels around the tumor, the vascular damage effect is considered to be one of the important mechanisms of photodynamic therapy for tumors. Therefore, the monitoring and research of the vascular damage effect in tumor photodyna...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/20A61B6/00A61B8/00A61N5/067G06T1/00G06T7/00
Inventor 邢达向良忠
Owner SOUTH CHINA NORMAL UNIVERSITY
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