Injection use medicine composition contg. water-soluble 17-allylamino-17-demethoxy geldanamycin
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- 深圳生尔易美生物技术有限公司
- Publication Date
- 2006-11-15
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a pharmaceutical composition for injection of 17-allylamino-17-demethoxygeldanamycin (17-AAG). Background technique
[0002] Anticancer antibiotics are chemical substances with anticancer activity produced by microbial metabolism. There are many kinds of anticancer antibiotics reported, among which more than 10 kinds have been used clinically. Mitomycin, doxorubicin, daunorubicin, bleomycin, pingyangmycin, dactinomycin and other anticancer antibiotics of natural origin and chemically modified analogues have become more commonly used drugs for the treatment of tumors. An important component of the anticancer drug arsenal.
[0003] At present, anticancer antibiotics acting on various targets have been reported one after another. The main targets include tumor blood vessels, DNA templates, matrix metalloproteinases, and heat shock protein 90 (HSP90). It has attracted attention due to its remarkable anticancer effect. Geldanamy...