Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drop pills for treating coronary heart disease and angina pectoris and preparation method thereof

A technology for coronary heart disease angina pectoris and dripping pills, applied in the field of medicine, can solve the problems of first-pass effect bioavailability of the liver, no report on the content of the extract, inconvenience in taking and carrying, etc., so as to increase the bioavailability and facilitate cleaning Hygiene, effects of increasing solubility and dissolution rate

Inactive Publication Date: 2006-12-27
SHANGHAI JIAO TONG UNIV
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have relatively large doses, long dissolution time, low dissolution rate, poor absorption, hepatic first-pass effect and low bioavailability, etc. problems, thus affecting the efficacy of the drug, and directly affecting the therapeutic effect
[0003] After searching the existing technical literature, it is found that there are no dripping pills prepared from the three effective parts of Panax notoginseng saponins, safflower yellow and Chuanxiong total phenols. Most of Sanqi, safflower and Chuanxiong are composed of medicinal materials. Most of the medicines are prepared with fine powder and crude extract. For example, the patent application number is 200410096330.1 and the name is "A Shuxiong Dropping Pill for Treating Heart Disease and Its Preparation Method". The safflower is only decocted in simple water, the active ingredient content is low, the dosage is large, and the dosage of the prepared drop pills is large, which makes it inconvenient to take and carry; Method", this technology is also a combination of three medicinal materials; Ni Jian and Yan Ping only mentioned the three medicinal materials in the article "Study on the Preparation Technology of Shuxiong Dropping Pills" (Chinese Herbal Medicine, 2003, 34(12): 1087-1089). The extract is self-made, no specific method is involved, and the general concept of extract is crude extract
And none of the above documents reported the content of the extract

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drop pills for treating coronary heart disease and angina pectoris and preparation method thereof
  • Drop pills for treating coronary heart disease and angina pectoris and preparation method thereof
  • Drop pills for treating coronary heart disease and angina pectoris and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The composition and weight percentage of the dropping pills are: polyethylene glycol 6000 60%, total saponins of Panax notoginseng 20%, safflower yellow 10%, total phenols of Ligusticum chuanxiong 10%

[0028]Preparation of Panax notoginseng saponins: take Panax notoginseng, crush it into coarse powder, reflux three times with 75% ethanol, add 10 times the amount of solvent each time, extract for 3 hours, combine the extracts for 3 times, filter, concentrate the filtrate to a paste, add 5 times Measure the water, let it stand overnight, filter, add the supernatant to the treated macroporous adsorption resin, first elute with 8 times the amount of deionized water, then elute with 70% ethanol solution, collect the eluate, Add 1% activated carbon for decolorization, filter, and recover ethanol from the filtrate under reduced pressure, dry, pulverize, sieve, and set aside;

[0029] Preparation of safflower yellow pigment: take safflower, crush it into coarse powder, add 10 ...

Embodiment 2

[0034] The composition and weight percentage of the dropping pills are: polyethylene glycol 6000 60%, polyethylene glycol 4000 20%, total saponins of Panax notoginseng 10%, safflower yellow pigment 5%, and total phenols of Ligusticum chuanxiong 5%.

[0035] Preparation of Panax notoginseng saponins: take Panax notoginseng, crush it into coarse powder, reflux twice with 75% ethanol, add 8 times the amount of solvent each time, extract for 2 hours, combine the two extracts, filter, concentrate the filtrate to a paste, add 5 Double the amount of water, let it stand overnight, filter, add the supernatant to the treated macroporous adsorption resin, first elute with 8 times the amount of deionized water, then elute with 60% ethanol solution, and collect the eluate , add 1% activated carbon for decolorization, filter, and recover ethanol from the filtrate under reduced pressure, dry, pulverize, sieve, and set aside;

[0036] Preparation of safflower yellow pigment: take safflower, c...

Embodiment 3

[0041] The composition and percentage by weight of the dropping pills are: polyethylene glycol 6000 42%, sodium stearate 25%, glycerol monostearate 25%, poloxamer 5%, Panax notoginseng saponins 1%, safflower yellow Pigment 1%, Chuanxiong total phenol 1%.

[0042] Preparation of Panax notoginseng saponins: take Panax notoginseng, crush it into coarse powder, reflux twice with 75% ethanol, add 6 times the amount of solvent each time, extract for 1 hour, combine the two extracts, filter, concentrate the filtrate to a paste, add 5 Double the amount of water, let it stand overnight, filter, add the supernatant to the treated macroporous adsorption resin, first elute with 8 times the amount of deionized water, then elute with 50% ethanol solution, and collect the eluate , add 1% activated carbon for decolorization, filter, and recover ethanol from the filtrate under reduced pressure, dry, pulverize, sieve, and set aside;

[0043] Preparation of safflower yellow pigment: take safflo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Disclosed is a dropping pill for treating coronary disease and angina pectoris, and process for preparation, wherein the pill comprises (by weight ratio) panax notoginseng saponins 1-20%, carthamus tinctorius yellow color 1-10%, Ligusticum wallichii phenol 1-10%, and balancing base material including polyethylene glycol 6000 25-60%, polyethylene glycol 4000 0-25%, sodium stearate 0-25%, poloxamer 0-5%, and glycerin monostearate 0-25%.

Description

technical field [0001] The invention relates to a medicine in the technical field of medicine and a preparation method thereof, in particular to a drop pill for treating angina pectoris of coronary heart disease and a preparation method thereof. Background technique [0002] Coronary heart disease and angina pectoris are common clinical diseases and frequently-occurring diseases, which seriously endanger the normal work, study and life of the middle-aged and elderly people. In recent years, these diseases have gradually become younger. The development of treatment for cardiovascular and cerebrovascular diseases Drugs have become a hotspot of current research. At present, various western medicine preparations are widely used in the clinical treatment of such diseases, but most of them have more and heavier side effects, while the application varieties of traditional Chinese medicine preparations are less. More and more clinical reports have shown that traditional Chinese med...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K9/20A61K47/34A61P9/10A61K47/10A61K47/12A61K47/14
Inventor 贾伟邱明丰周明眉谢国祥张汉杰
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com