Biological material film with porous structure and its prepn

A technology of biomaterials and porous structures, applied in medical science, prostheses, etc., can solve the problems of membrane exposure, influence, lack of active induction of differentiation and growth promotion, etc.

Inactive Publication Date: 2007-01-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it cannot be degraded by itself in the body, a second operation is required to remove it. If it is kept in place, complications such as bacterial infection will occur, and it is easy to cause soft tissue flap cracking and early exposure of the membrane, which will affect the amount of new bone formation.
[0004] The common di

Method used

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  • Biological material film with porous structure and its prepn
  • Biological material film with porous structure and its prepn
  • Biological material film with porous structure and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0041] Example 1

[0042] Dissolve 10g of polyamide 66 in 100ml of ethanol at 70~80℃ under stirring and the action of calcium chloride as a catalyst to prepare polyamide 66 film-forming liquid. After the film-forming liquid is cooled to 30-40℃, it will be about 1.5ml Pour the film-forming solution onto a glass plate with a diameter of 12cm, and spread it freely to form a film, dry at 70°C, mark the front and back with a marker, soak and wash several times with 200ml of deionized water, and check that there is no chloride ion in the eluate with 1M silver nitrate (The soaking time is more than 30 minutes each time), drying at 70°C, to obtain the polyamide 66 porous biofilm of the present invention.

[0043] The prepared polyamide 66 membrane has a porous structure, and the pores are interpenetrated with each other. The average pore diameter is about 60-70 μm, and the structure is like figure 1 Shown. Measured with a vernier caliper, the thickness of the...

Example Embodiment

[0044] Example 2

[0045]Dissolve 20g of polyamide 66 in 100ml of ethanol at 70~80℃ under stirring and the action of calcium chloride as a catalyst to prepare polyamide 66 film-forming liquid. After the film-forming liquid is cooled to 30-40℃, about 2.5ml Pour the film-forming solution onto a glass plate with a diameter of 12cm and spin it to form a film, dry at 60℃, mark the front and back with a marker, soak and wash several times with 200ml of deionized water, and check that there is no chloride ion in the eluate with 1M silver nitrate solution. (The soaking time is more than 30 minutes each time), drying at 70° C., to obtain the polyamide 66 porous biofilm of the present invention.

[0046] The prepared polyamide 66 membrane has a porous structure, the pores are interpenetrated with each other, and the average pore diameter is about 50-70 μm. Measured with a vernier caliper, the thickness of the porous film is 0.2 mm.

Example Embodiment

[0047] Example 3

[0048] Dissolve 10g of polyamide 6 in 100ml of ethanol at 70~80℃ under stirring and the action of calcium chloride as a catalyst to prepare polyamide 6 film-forming liquid. After the film-forming liquid is cooled to 30-40℃, about 2ml is formed into The membrane solution was poured on a glass plate with a diameter of 12cm to freely spread to form a membrane, dried at 70°C, marked the front and back with a marker, soaked and washed several times with 200ml of deionized water, 1M silver nitrate solution was checked for the absence of chloride ions in the eluate ( The immersion time is more than 30 minutes each time) and dried at 70°C to obtain the polyamide 6 porous biofilm of the present invention.

[0049] The prepared polyamide 6 membrane has a porous structure, the pores are interpenetrated with each other, and the average pore diameter is about 60-70 μm. Measured with a vernier caliper, the thickness of the porous film is 0.12 mm.

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Abstract

The biological material film with porous structure is medical film of polyamide or composite polyamide/nanometer osteolith material with through pores in gradually changed sizes, and has one compact side with fine pores in diameters of 0.01-30 microns and the opposite loose side with large pores in diameters of 30-300 microns. During its preparation, solvent with high volatility is used as the dispersant, medical polyamide or composite polyamide/nanometer osteolith material is heated and stirred to form the filming liquid, and film is formed and washed with deionized water to obtain the biological film. The porous biological film has controllable porous structure, and excellent mechanical performance and biological performance, and may be used widely as medial separating film, medicine slow releasing film, tissue regeneration inducing film, etc.

Description

technical field [0001] The invention relates to a biomaterial film which can be used in the medical and health field and a preparation method thereof. Background technique [0002] Since the 1990s, the use of artificial biofilms to guide the regenerative healing of body tissues has become an international hot research topic. Bio-membrane technology (Barrier Membrane Technique, referred to as BMT) is a new clinical treatment technology that has attracted widespread attention in the medical field in recent years. The principle of guided bone tissue regeneration is to use the physical barrier function of the biofilm to isolate the bone defect area from the surrounding tissue, create a relatively closed tissue environment, prevent the fibrous knot tissue from growing into the bone defect area, and protect the wound area. Blocking, guiding or inducing functions can fully mobilize the repair and healing potential of the tissue itself, and finally enable the regeneration and recon...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56
Inventor 李玉宝李吉东左奕
Owner SICHUAN UNIV
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