Prodrug of taxol or polyene-taxol with carbowax as carrier
A technology of docetaxel and polyethylene glycol, which is applied in the field of water-soluble paclitaxel or derivative compounds of docetaxel, which can solve the problems of large toxic side effects and inconvenient application, and achieve the effect of improving solubility
Active Publication Date: 2007-01-17
SHANGHAI ALLIST PHARM CO LTD
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A precursor of taxol or polyenyl taxol with higher water solubility and tumor suppressing efficiency is prepared from polyethanediol as carrier, hydroxyacetic acid, or L-lactic acid, or their oligomer as linking arm, and taxol or polyenyl taxol through bonding reaction on the hydroxy groups at the site 2' or 7' of taxol or polyenyl taxol.
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