Medical super fire micro capsule capsaicine and its preparing method

An ultra-fine capsaicin technology, applied in the direction of microcapsule preparation, microsphere preparation, microcapsules, etc., can solve the problems of large particle size, poor controllability, difficult application, etc., and achieve simple preparation process, uniform particle size distribution, and production low cost effect

Inactive Publication Date: 2007-01-24
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] But there is a significant defect in above-mentioned technology, and this microcapsule can't meet edible requirement, is difficult to be applied to the aspects such as medicine, beauty care, food, and particle diameter is bigger, and regulation property is poor, is not easy to human body absorption, so the implementation of the present invention has necessity and creativity

Method used

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  • Medical super fire micro capsule capsaicine and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] First prepare 100ml of gelatin aqueous solution with a weight concentration of 1%, swell for 0.5h, heat up to 40°C, add 1g of capsaicin and 2ml of polyoxyethylene sorbitan monooleate aqueous solution with a weight concentration of 5%, and disperse with ultrasonic stirring 30min; add 30ml of absolute ethanol, react at 45°C for 1h, stop heating, stir until the system drops to 20°C; use ice bath to lower the system to 10°C, add glutaraldehyde aqueous solution with a weight concentration of 6% to cross-link and solidify 0.2h; wash the product with water and place it in a three-necked flask, keep the temperature of the water bath at 20°C, then add dropwise 20ml of tannic acid aqueous solution with a weight concentration of 10%, and treat for 2h; wash the final product with water several times and then dry it with suction. The average particle size of the product is shown in Table 1. TEM photo see figure 1 .

Embodiment 2

[0023] First prepare 100ml of gelatin aqueous solution with a weight concentration of 5%, swell for 0.6h, heat up to 45°C, add 2g of capsaicin and 2ml of polyoxyethylene sorbitan monooleate with a concentration of 6%, and disperse with ultrasonic stirring for 30min ;Add 30ml of absolute ethanol, react at 46°C for 1h, stop heating, stir until the system drops to 30°C; use an ice bath to lower the system to 5°C, add 7% glutaraldehyde aqueous solution to cross-link and solidify 0.3 h; wash the product with water and place it in a three-necked flask, keep the temperature of the water bath at 25°C, then add 20ml of tannic acid aqueous solution with a concentration of 10% by weight dropwise, and treat for 2h; wash the final product with water several times and then dry it with suction.

[0024] The average particle size of the product is shown in Table 1.

Embodiment 3

[0026] First prepare a gelatin aqueous solution with a weight concentration of 5%, swell for 0.7h, heat up to 45°C, add 3g of capsaicin and 3ml of an aqueous solution of polyoxyethylene sorbitan monooleate with a weight concentration of 7%, and disperse with ultrasonic stirring 30min; add 40ml of absolute ethanol, react at 47°C for 1h, stop heating, stir until the system drops to 15°C; use ice bath to lower the system to 1°C, add glutaraldehyde aqueous solution with a weight concentration of 8% to cross-link and solidify 0.4h; wash the product with water and place it in a three-necked flask, keep the temperature of the water bath at 30°C, then add 20ml of tannic acid aqueous solution with a weight concentration of 10% dropwise, and treat for 2h; wash the final product with water several times, and then dry it with suction. The average particle size of the product is shown in Table 1.

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Abstract

The present invention discloses a kind of medicinal superfine capsaicine microcapsule and its preparation process. The preparation process includes the following steps: 1. compounding gelatin aqua, swelling and heating to 40-50deg.c; 2. adding capsaicine and water solution of polyoxyethylene and sorbitol oleate through stirring; 3. adding coagulant to react and cooling; 4. adding water solution of glutaraldehyde for crosslinking solidification; and 5. water washing the product of the step 4, dropping water solution of tannic acid and collecting the medicinal superfine capsaicine microcapsule. The microcapsule has homogeneous and controllable particle size of 100-300 nm, and may be used widely in medicine, health product, food, etc.

Description

technical field [0001] The invention relates to an ultrafine microcapsule containing capsaicin and a preparation method thereof. Background technique [0002] Capsaicin is an alkaloid containing vanillic amide. Natural capsaicin is composed of capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, homocapsaicin and other similar species, of which trans-8 -Methyl-N-vanillyl-6-nonenylamide has the most intense spicy taste and very strong irritation. It is the main chemical component of spicy pepper fruit, and has a variety of complex physiological and pharmacological activities and biological Functions: ① Analgesia: High-purity capsaicin has a significant effect on herpes zoster neuralgia, diabetic neuralgia, cancer neuralgia, etc. It is an ideal analgesic drug, and its superiority in analgesia is promising Alternative to morphine. ② Anti-inflammatory: Capsaicin has a good therapeutic effect on rheumatoid arthritis, osteoarthritis and chronic rhinitis. ③Det...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/16A61K47/42B01J13/08A61P25/04A61P25/30A61P19/02A61P29/00
Inventor 王锦成陈思浩徐子成
Owner SHANGHAI UNIV OF ENG SCI
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