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Monascus novel strain and traditional Chinese medicine monascus prepared by fermenting the same

A new strain and technology of red yeast rice, applied in fermentation, fungi, drug combination, etc., can solve the problems of high ring-opening ratio and high polyunsaturated fatty acid content, and achieve high ring-opening ratio, high polyunsaturated fatty acid content, The effect of high yield

Active Publication Date: 2007-02-07
CHENGDU DIAO JIUHONG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] In summary, there is no report on the production of traditional Chinese medicine lipid-lowering red yeast rice by fermenting Monascus with high lovastatin content, high ring-opening ratio, high polyunsaturated fatty acid content, and almost no citrinin.

Method used

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  • Monascus novel strain and traditional Chinese medicine monascus prepared by fermenting the same
  • Monascus novel strain and traditional Chinese medicine monascus prepared by fermenting the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 The preparation of Chinese medicine lipid-lowering red yeast rice of the present invention: (numbering A)

[0046] The bacterial classification used in the present invention is obtained from soil isolation, identified as purple Monascus (Monascus Purpureus Went) bacterium by Sichuan University Institute of Bioengineering, and preserved by China Typical Culture Collection Center (CCTCC), and the preservation number is CCTCC M 205073.

[0047] After the batch of working seed strains are opened, cultivate them on PDA agar medium plate and store them on the slope of the PDA test tube. , Observing under the microscope after Gram staining, the seeds with the same morphology under the microscope and no bacterial contamination are qualified seeds. Production capacity inspection is to detect the production capacity of the strain (ie the open-ring content per milliliter of fermentation broth) by fermentation at the laboratory level, and any production capacity great...

Embodiment 2

[0050] Embodiment 2 The preparation of Chinese medicine lipid-lowering red yeast rice of the present invention:

[0051] The bacterial classification used in the present invention is obtained from soil isolation, identified as purple Monascus (Monascus Purpureus Went) bacterium by Sichuan University Institute of Bioengineering, and preserved by China Typical Culture Collection Center (CCTCC), and the preservation number is CCTCC M 205073.

[0052] After the batch of working seed strains are opened, cultivate them on PDA agar medium plate and store them on the slope of the PDA test tube. , Observing under the microscope after Gram staining, the seeds with the same morphology under the microscope and no bacterial contamination are qualified seeds. Production capacity inspection is to detect the production capacity of the strain (ie the open-ring content per milliliter of fermentation broth) by fermentation at the laboratory level, and any production capacity greater than 1ug / ml...

Embodiment 3

[0055] Embodiment 3 The preparation of Chinese medicine lipid-lowering red yeast rice of the present invention:

[0056] After the batch of working seed strains are opened, cultivate them on PDA agar medium plate and store them on the slope of the PDA test tube. , Observing under the microscope after Gram staining, the seeds with the same morphology under the microscope and no bacterial contamination are qualified seeds. Production capacity inspection is to detect the production capacity of the strain (ie the open-ring content per milliliter of fermentation broth) by fermentation at the laboratory level, and any production capacity greater than 1ug / ml is a qualified seed]. As seeds for production, the seeds are cultivated at 30-40° C., 180-220 rpm, in PDA medium for 8-24 hours as first-class seeds, and can also be used as fermenter seed liquid.

[0057] Components of solid-state fermentation nutrient solution (g / L): glycerin 150, peptone 150, beef extract 80, Na 2 HPO 4 12H...

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Abstract

the invention discloses a new strain of Monascus Purpureus Went and preparing method of traditional Chinese medicine antihyperglycemic Monascus color, which is composed of 15-30mg / g open, close ring structured Luovastatin, 3-6mg / g unsaturated fatty acid and not more than 100ppb orange mycin, wherein the content of open-structured Luovastatin is 15-90%.

Description

technical field [0001] The invention relates to a new strain of the genus Monascus and a traditional Chinese medicine for lowering lipid-lowering red yeast rice prepared by fermentation, in particular to a Chinese medicine for lowering lipid-lowering red yeast rice fermented by selected and domesticated red yeast rice strains, and belongs to the field of biotechnology. Background technique [0002] With the improvement of people's living standards and population aging, hyperlipidemia (mainly manifested as elevated serum cholesterol TC and triglyceride TG, decreased high-density lipoprotein cholesterol HDL-C, and increased low-density lipoprotein (LDL) Hyperlipidemia caused by lipid metabolism disorder has become an important pathogenic factor of common diseases such as fatty liver, coronary heart disease and atherosclerosis. [0003] At present, the commonly used drugs for lowering blood lipids in clinic are mainly divided into the following categories: 3-hydroxy-3-methylglu...

Claims

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Application Information

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IPC IPC(8): C12N1/14A61K36/06C12P1/02A61P3/06A61P1/16
Inventor 及元乔刘忠荣陈军赵海王若竹黄瑜李伯刚
Owner CHENGDU DIAO JIUHONG PHARMA FACTORY
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