Organism degradable star-type structure poly (glycolide-lactide) medicine carrier microsphere and preparation method thereof

A technology of polyglycolide and drug-carrying microspheres, which is applied in the directions of pharmaceutical formulations and medical preparations with inactive ingredients, can solve the problems of complicated experimental process, etc., so as to improve the poor packaging ability, improve the drug-carrying capacity and the packaging capacity. Buried rate effect
CN1927906AInactive Publication Date: 2007-03-14NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANKAI UNIV
Publication Date
2007-03-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to one kind of biodegradable medicine-carrying polyglycolide-lactide microsphere in star structure and its preparation process. The biodegradable medicine-carrying polyglycolide-lactide microsphere has coating material of star polyglycolide-lactide, coated protein polypeptide medicine of bovine serum albumin or leuteinizing hormone-releasing homone (LH-RH) analog, medicine carrying amount of 17.56-67.51 mcg / mg microsphere and embedding rate of 28.68-78.39 wt%. It is prepared through a W / O / W composite emulsifying process to coat protein polypeptide medicine into star polyglycolide-lactide to form microsphere. Compared with linear medicine-carrying polyglycolide-lactide microsphere, the present invention has obviously increased medicine carrying amount and embedding rate and obvious long-acting and slowly releasing effect.
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Description

technical field

[0001] The invention relates to a protein polypeptide drug-loaded microsphere and a preparation method thereof, in particular to a star-shaped biodegradable polylactide drug-loaded microsphere and a preparation method thereof. Background technique

[0002] With the development of biomedicine and biotechnology, protein peptide drugs are becoming a very important class of therapeutic agents. They have broad application prospects in the treatment of cancer, autoimmune diseases, memory loss, mental disorders, hypertension and certain cardiovascular and metabolic diseases, and have become important diagnostic, monitoring, preventive and therapeutic drugs. This type of drug is characterized by small dosage and strong biological activity. However, this type of drug is very sensitive to strong acid and proteolytic enzymes in the gastrointestinal tract after oral administration, and peptide and protein drugs are mostly hydrophilic macromolecular substances, which are ...

Claims

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