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Sustained release Brufen having magnetic super-molecular inserting layer structure and its prpen. method

A supramolecular intercalation and slow-release technology, which is applied in the direction of organic active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of non-magnetic supramolecular intercalation ibuprofen sustained-release dosage reports, etc. Achieve the effect of improving bioavailability, reducing unpleasant taste, and improving targeting

Inactive Publication Date: 2007-04-18
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But there is no report of magnetic supramolecular intercalation ibuprofen sustained-release dosage form at present

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Magnetic core MgFe 2 o 4 Preparation of Nanopowder

[0034] Weigh 5.128g (0.02Mol) Mg (NO 3 ) 2 ·6H 2 O, 4.04g (0.01Mol) Fe(NO 3 ) 3 9H 2 O and 1.99g (0.01Mol) FeCl 2 4H 2 O was dissolved in 100ml water to make a mixed salt solution, and 6g (0.15Mol) NaOH and 7.42g (0.07Mol) NaOH were weighed 2 CO 3 Dissolve in 100ml of water to make a mixed alkaline solution; drop the alkaline solution into the mixed salt solution until the pH value is 11, crystallize in a water bath at 40°C for 10 hours, filter the reaction solution with suction, wash, and then wash with absolute ethanol Washing, vacuum drying, grinding into powder, and then roasting at 800°C in an air atmosphere for 8 hours with a heating rate of 10°C / min to obtain the magnetic core MgFe 2 o 4 . Sieve with a standard sieve to obtain a relatively uniform powder. The water used in the process is decarbonized deionized water.

[0035] (2) Preparation of Magnesium Aluminum Hydrotalcite Intercalated wit...

Embodiment 2

[0039] (1) Magnetic core MgFe 2 o 4 Preparation of Nanopowder

[0040] Weigh 5.128g (0.02Mol) Mg (NO 3 ) 2 ·6H 2 O, 4.04g (0.01Mol) Fe(NO 3 ) 3 9H 2 O and 1.99g (0.01Mol) FeCl 2 4H 2 O was dissolved in 100ml water to make a mixed salt solution, and 6g (0.15Mol) NaOH and 7.42g (0.07Mol) NaOH were weighed 2 CO 3 Dissolve in 100ml of water to make a mixed alkaline solution; drop the alkaline solution into the mixed salt solution until the pH value is 11, crystallize in a water bath at 40°C for 10 hours, filter the reaction solution with suction, wash, and then wash with absolute ethanol Washing, vacuum drying, grinding into powder, and then roasting at 800°C in an air atmosphere for 8 hours with a heating rate of 10°C / min to obtain the magnetic core MgFe 2 o 4 . Sieve with a standard sieve to obtain a relatively uniform powder. The water used in the process is decarbonized deionized water.

[0041] (2) Preparation of Magnesium Aluminum Hydrotalcite Intercalated wit...

Embodiment 3

[0045] (1) Magnetic core MgFe 2 o 4 Preparation of Nanopowder

[0046] Weigh 5.128g (0.02Mol) Mg (NO 3 ) 2 ·6H 2 O, 4.04g (0.01Mol) Fe(NO 3 ) 3 9H 2 O and 1.99g (0.01Mol) FeCl 2 4H 2 O was dissolved in 100ml water to make a mixed salt solution, and 6g (0.15Mol) NaOH and 7.42g (0.07Mol) NaOH were weighed 2 CO 3 Dissolve in 100ml of water to make a mixed alkaline solution; drop the alkaline solution into the mixed salt solution until the pH value is 11, crystallize in a water bath at 40°C for 10 hours, filter the reaction solution with suction, wash, and then wash with absolute ethanol Washing, vacuum drying, grinding into powder, and then roasting at 800°C in an air atmosphere for 8 hours with a heating rate of 10°C / min to obtain the magnetic core MgFe 2 o 4 . Sieve with a standard sieve to obtain a relatively uniform powder. The water used in the process is decarbonized deionized water.

[0047] (2) Preparation of Magnesium Aluminum Hydrotalcite Intercalated wit...

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Abstract

A slow-release ibuprofen with magnetic super-molecular intercalated structure, controllable release speed, high magnetic dispersity, and high magnetic target effect is prepared from spinel, anionic laminated material LDHs, and alkaline solution of ibuprofen through intercalating assembling.

Description

technical field [0001] The invention belongs to the technical field of magnetic sustained-release agents, in particular to a sustained-release ibuprofen with a magnetic supramolecular intercalation structure and a preparation method thereof, in particular to a sustained-release ibuprofen with a magnetic supramolecular intercalation structure and an assembly method thereof . Background technique [0002] Magnetic slow-release drugs are a kind of drugs that integrate magnetism and controlled release. When such drugs are used in the body, the magnetic field effect outside the body can guide the drug to move and concentrate in the body, and realize the controlled release of the drug. Therefore, such drugs are mainly used as carriers of anticancer drugs. Animal experiments and clinical observations have proved that magnetic drugs have a definite effect of inhibiting the growth of cancer cells, shrinking tumors of patients, and improving subjective symptoms. [0003] Existing mag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/192A61K47/02A61P29/00
Inventor 张慧盘登科文杏
Owner BEIJING UNIV OF CHEM TECH
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