Antibacterial composition

A composition and antibacterial technology, applied in the field of compositions with antibacterial activity, can solve the problem of no antibacterial effect of liquid diet

Active Publication Date: 2007-05-09
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] If liquid diet has antibacterial effect, it can be one of the means of preventing infection in susceptible persons, but so far, there is no report on the antibacterial effect of liquid diet

Method used

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  • Antibacterial composition
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Examples

Experimental program
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Effect test

Embodiment 1

[0051] [Example 1] Research on antibacterial effect of acidic liquid diet (1)

[0052] The antibacterial effect of acidic liquid diet against pathogenic bacteria was studied. Use Escherichia coli IFO3972 (E. coli), Staphylococcus aureus subsp. aureus IFO 12732 (Staphylococcus aureus), Pseudomonas aeruginosa NBRC 13275 (Pseudomonas aeruginosa), Staphylococcus aureus 11D 1677 (MRSA), Streptococcus mutans IFO13955 (Dental caries) as the test bacteria. The bacterial solution was prepared as follows: Dental caries were cultured on Trypto Soy (トリプトソイ) agar medium (manufactured by Eiken Chemical Co., Ltd.), and other test bacteria were cultured on ordinary agar medium (manufactured by Eiken Chemical Co., Ltd.), and the obtained bacteria were suspended. In sterilized physiological saline, the number of bacteria per 1ml reaches about 10 8 -10 9 . The acidic liquid diet was prepared by mixing the acidic liquid diet shown in Table 1, and the neutral liquid diet (Meiballan, Meiji Dair...

Embodiment 2

[0056] [Example 2] Research on the Antibacterial Effect of Organic Acids

[0057] Since the antibacterial effect of the acidic liquid diet was confirmed, the component composition of the acidic liquid diet was studied. The composition of neutral liquid diet, acidic liquid diet, and fermented milk preparation liquid is shown in Table 2. Neutral liquid diets contain citric acid for pH adjustment but few other organic acids. The fermented milk preparation contains 405.1 mg / 100 ml of lactic acid produced by lactic acid fermentation. The lactic acid contained in the acidic liquid diet is about twice that of the fermented milk preparation. This is because calcium lactate is added to ensure the amount of calcium necessary for the liquid diet. The acidic liquid diet and the fermented milk preparation contained a large amount of citric acid and acetic acid as the main organic acids other than lactic acid (Table 2).

[0058] Element

neutral liquid diet

acidic liqu...

Embodiment 3

[0062] [Example 3] Research on antibacterial effect of acidic liquid diet (2)

[0063] As described above, the antibacterial effect of the acidic liquid diet on various bacteria was confirmed, and the antibacterial effect on Helicobacter pylori ATCC43504 (Helicobacter pylori) and Clostridium difficile JCM1296 (Clostridium difficile) was investigated. Helicobacter pylori is a gram-negative bacterium and Clostridium difficile is a gram-positive bacterium. The study on the antibacterial effect of Helicobacter pylori was carried out as follows: First, using sheep blood agar medium (manufactured by Eiken Chemical Co., Ltd.), microaerophilic culture was carried out at 35° C. for 3 days, and then suspended in sterilized physiological saline. The number of bacteria reached about 10 7 -10 8 Modulate to make bacterial liquid. Add 0.5ml of Helicobacter pylori to 4.5ml of acidic liquid diet, sterilized normal saline as a control, 4.5ml of Brucella broth supplemented with 5% horse serum...

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Abstract

It is intended to prevent contamination with the use of a food. As a candidate food, attention is given to an acidic fluid food which comprises an antibacterial fluid food having been acidified by adding a fermented milk product as a protein source. The antibacterial function of the acidic fluid food is compared with the antibacterial functions of the fermented milk product employed as the starting material and a neutral fluid food. Although it has been already known that fermented milk such as yogurt has an antibacterial function, the above-described acidic fluid food unexpectedly shows a stronger antibacterial function than the fermented milk product employed as the starting material on gram-positive bacteria such as MRSA which are important from the viewpoint of public health.

Description

technical field [0001] The present invention relates to compositions having antimicrobial activity. Background technique [0002] Liquid diets are widely used in hospitals, nursing homes, etc., and are used for those who have difficulty in taking in oral nutrition or have swallowing disorders. Liquid diets are injected into the body through catheters and tubes inserted through the nasal cavity, PEG (percutaneous endoscopic gastrostomy), etc., but generally, the users of liquid diets are the elderly or patients with certain diseases. Low immunity, easy to be infected with pathogenic bacteria. [0003] In such institutions where there are many susceptible persons, once infection occurs, it may develop into nosocomial infection or institutional infection through medical staff and the like. Although the awareness of measures to prevent nosocomial infection has increased, there are more and more problems of nosocomial infection due to the increase of elderly people and the emer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/20A23L1/30A23L1/305A61K35/74A61P31/04A23L3/3463A23L33/00
CPCA61K35/20A23L1/296A23L1/3056A23V2002/00A23L33/40A23L33/19A61P31/00A61P31/04A23V2200/3204A23V2250/5424A23V2250/5114A23V2250/5072A23V2250/1842A23V2250/54242A23V2250/022A23V2250/032A23V2250/034
Inventor 粂久枝佐佐木一
Owner MEIJI CO LTD
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