Anti-microbial perfuming compositions

a technology of compositions and perfuming ingredients, applied in the field of anti-microbial perfuming compositions, can solve the problems of inability to evaluate the activity of compounds, inability to exploit the potential use of perfuming ingredients in the past, and inability to provide quantitative results. quantitative results, the effect of known tests

Inactive Publication Date: 2002-10-03
FIRMENICH SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this potential use of the perfuming ingredients has not been exploited in the past.
The conclusion in the above application is that the methods disclosed are not reliable, e.g. because conflicting results have been obtained for a given ingredient against one and the same microorganism, or because results obtained for a certain microorganism cannot be transferred to another microorganism.
However, this known test does not provide quantitative results which permit a real evaluation of a compound's activity.
Furthermore, the surfactants employed in the concentrations indicated (iso-octyl-phenoxypolyethoxy-ethanol and sodium dodecyl sulfate) do not solubilize the hydrophobic perfuming ingredients in the aqueous solution.
Therefore, they will not make proper contact with the inoculated bacteria, which are present in the aqueous phase.
This creates an inherent error in the measurement and renders the procedure unreliable.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0033] An anti-microbial Composition was Prepared with the Following Ingredients:

2 Ingredients Parts by weight Benzyl acetate 500 Hexylcinnamic aldehyde 1000 .sup.x (2E,6Z)-2,6-nonadien-1-ol* 5 .sup.x Citronellol 500 Coumarine 300 .sup.x .gamma.-Dodecalactone 50 Lorysia .RTM..sup.1) 1000 Heliotropine 200 .sup.xIsobutylquinoleine 50 .sup.xLilial 2500 .sup.xMayol .RTM. 1000 Phenethylol 400 .sup.xPhenylhexanol 1500 Polysantol .RTM. 500 Total 9505 *in dipropylene glycol x =active compound according to the present invention .sup.1)4-(1,1-dimethylethyl)-1-cyclohexyl acetate; origin: Firmenich SA, Geneva, Switzerland

[0034] The composition thus prepared showed an anti-microbial activity of 100% against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, as measured by the test according to the present invention.

example 2

[0035] A perfuming Composition was Prepared by Using the Following Ingredients:

3 Ingredients Parts by weight Benzyl acetate 500 Linalyl acetate 500 .sup.xCitronellol 300 .sup.xCyclamen aldehyde 100 .sup.x.gamma.-Dodecalacto-ne 20 .sup.xGeraniol 200 Habanolide .RTM..sup.1) 500 .sup.xLilial .RTM. 1000 .sup.xMayol .RTM. 300 Phenethylol 800 .sup.xPhenylhexanol 500 Benzyl salicylate 800 Terpineol 1000 Total 6520 x= active compound according to the present invention .sup.1)mixture of pentadec-11-en-15-olide and pentadec-12-en-15-olide ; origin Firmenich SA, Geneva, Switzerland

[0036] The composition thus prepared showed an anti-microbial activity of 100% against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, as measured by the test according to the present invention.

example 3

[0037] There was Prepared a Perfuming Composition Using the Following Ingredients:

4 Ingredients Parts by weight .sup.xNonanal 10 Hexylcinnamic aldehyde 800 .sup.xIntreleven aldehyde 10 .sup.x4-Undecanolide 10 .sup.xCitronellol 1500 .sup.xGeraniol 1000 Habanolide .RTM..sup.1) 800 Iralia .RTM. Total.sup.2) 200 Isopentyrate.sup.3) 400 Dorisyl.sup.1) 800 Lyral .RTM. .sup.4) 500 .sup.xPhenylhexanol 1000 .sup.xTetrahydrolinalool 1500 Total 8530 .sup.x= active compound according to the present invention .sup.1)see Example 2 .sup.2)methylionone mixture ; origin: Firmenich SA, Geneva, Switzerland .sup.3)1,3-dimethyl-3-butenyl isobutyrate ; origin : Firmenich SA, Geneva, Switzerland .sup.4)mixture of 4-and 3-(4-hydroxy-4-methylpentyl)-3-cyclohexene-1-carbaldehyde; origin: International Flavors & Fragrances, USA

[0038] The composition thus prepared showed an anti-microbial activity of 100% against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, as measured by the test accord...

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Abstract

The present invention describes perfumes and perfuming compositions having an anti-microbial activity and containing effective amounts of certain perfuming ingredients which have an anti-microbial activity as evaluated by the Microbial Reduction Test.

Description

[0001] This application is a continuation of International application PCT / IB00 / 01389 filed Sep. 28, 2000, the content of which is expressly incorporated herein by reference thereto.TECHNICAL FIELD AND PRIOR ART[0002] The present invention concerns the field of perfuming ingredients and compositions which have an anti-microbial effect. The application also describes a new test which is particularly adapted for determining the anti-microbial activity of perfuming ingredients.[0003] In the perfume industry as well as in industries in which perfumes and perfuming compositions are used (as, for example, in companies which manufacture dish-washing liquids, all-purpose cleaners, shampoos or even cosmetic products), there is a great tendency towards the creation and use of perfuming compositions having an anti-microbial effect. This is due to the fact that there is an increasing consumer demand for products which have both an activity against bacteria and other microorganisms, and fulfill ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A01N25/02A01N31/02A01N31/04A01N31/06A61L9/01A01N31/16A01N35/02A01N35/04A01N43/08A01N43/30A01N49/00A01N61/00A61K8/00A61K8/34A61K8/35A61K8/49A61K31/045A61K31/11A61K31/12A61K31/36A61Q5/00A61Q5/02A61Q15/00A61Q19/10C11B9/00C11D3/48C11D3/50C12Q1/18
CPCA01N31/02A01N31/06A01N35/02A01N35/04A01N43/08C12Q1/18A01N61/00A61K8/33A61K2800/77A61Q13/00A01N49/00
Inventor BRETLER, GIL
Owner FIRMENICH SA
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