Composite scaffolds and methods using same for generating complex tissue grafts

a technology of composite scaffolds and tissue grafts, which is applied in the direction of genetically modified cells, skeletal/connective tissue cells, prostheses, etc., can solve the problems of reducing the supply of donor organs, unable to provide pharmaceutical replacement therapy, and unable to provide full immune protection for patients
US20040203146A1Inactive Publication Date: 2004-10-14YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
Publication Date
2004-10-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting, formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 $G(m)m.
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Description

FIELD AND BACKGROUND OF THE INVENTION

[0001] The present invention relates to composite scaffolds capable of supporting growth of complex tissue and to methods of manufacturing and using same.

[0002] Traditional medical treatments for functional deficiencies in organs have focused on using pharmaceutical compositions for replacing such functional deficiencies. However, in some cases, pharmaceutical replacement therapy cannot be instated since organ function is oftentimes complex and / or not completely understood.

[0003] In such cases, the only viable alternative is surgical replacement of the non-functional organ, however, in most cases, organ transplantation requires continuous use of immunosuppressive agents to prevent immunological rejection of the organ, depriving the patient of the full protective function of the immune system.

[0004] Moreover, the need for donor organs far exceeds the supply. Organ shortage has resulted in new surgical techniques, such as splitting adult organs for...

Claims

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