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Decontamination of prion-contaminated surfaces with phenols

a technology of phenols and prion, applied in the field of biological decontamination, can solve the problems of ineffective breakdown, tissue damage, cell death, etc., and achieve the effect of deactivating prions quickly and effectively and facilitating instruments

Inactive Publication Date: 2005-02-10
AMERICAN STERILIZER CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for effectively treating a body that is contaminated with prions using a composition containing a phenol. The method is gentle on instruments and deactivates prions quickly and effectively. The composition is compatible with a wide variety of materials and devices. The invention also provides a method for determining the effectiveness of the composition by measuring the amount of phenol taken up by the material.

Problems solved by technology

The abnormal form of the protein is not broken down effectively in the body and its accumulation in certain tissues (in particular neural tissue) eventually causes tissue damage, such as cell death.
Concerns are being raised that procedures previously considered to be “low risk” in terms of prion infection, such as tonsillectomy and dental procedures, may pose unacceptable risks of infection, particularly, if the incidence of prion-related diseases increases.
During the long incubation period, it is extremely difficult to determine whether a surgical candidate is a prion carrier.
Prions are notoriously very hardy and demonstrate resistance to routine methods of decontamination and sterilization.
These aggressive treatments are often incompatible with medical devices, particularly flexible endoscopes and other devices with plastic, brass, or aluminum parts.
Many devices are damaged by exposure to high temperatures.
Chemical treatments, such as strong alkali, are damaging to medical device materials or surfaces in general.
In other studies, phenols have generally been found not to be effective against prions.

Method used

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  • Decontamination of prion-contaminated surfaces with phenols
  • Decontamination of prion-contaminated surfaces with phenols
  • Decontamination of prion-contaminated surfaces with phenols

Examples

Experimental program
Comparison scheme
Effect test

example 1

Study of the Effect of Phenol Concentration on the Effectiveness of the Composition

To test the contribution of various formulation effects on the priocidal activity of various compositions experiments are performed using IFDO log reduction as the response. The ingredients of compositions I-VII are listed in Table 1. Composition I is a commercial formulation, LpH™.

The IFDOs are artificially cultured in a modified Mycoplasma broth and quantified by serial dilutions and plating on a similar agar. The efficacy of the compositions I-VII is studied by suspension testing at room temperature at a 1% dilution of the composition in water. Following a suitable contact time, e.g., 10 minutes, aliquots are sampled and quantified by serial dilution and plating into modified Mycoplasma agar. Following incubation at 37° C. for 48 hours, the plates are evaluated by counting visible colonies and log reductions are determined. Results with the compositions are compared with an existing phenolic pr...

example 2

Effect of Approximately Equimolar Concentrations of Phenols

Various phenols at approximately equimolar concentrations (where possible when solubility permitted) are studied by the method of EXAMPLE 1. TABLE 2 shows the ingredients by weight for formulations IX-XX and the results obtained.

TABLE 2MolMolecularPhenol / Ingredientwt100 gIXXXIXIIXIIIXIV2,3-Dimethylphenol122.170.09011.00o-Benzyl-p-218.690.08618.86Chlorophenolo-Phenylphenol142.580.08414.29p-Chloro-m-Cresol156.610.08712.45p-Chloro-m-Xylenol150.20.09915.502,4,5-197.460.09017.80TrichlorophenolHexylene Glycol4.003.956.294.214.004.23iso-Propyl alcohol8.007.907.628.148.408.08Sodium22.4618.8620.6019.9219.8019.60LaurylsulfateAlpha olefin6.706.326.106.037.006.45sulfonateGlycolic Acid19.0018.6817.1418.3021.0018.00Triethanolamine2.501.430.951.341.401.02Soft Water26.3424.0027.0129.6122.9024.82Log Reduction4.14.74.84.34.44.9MolMolecularPhenol / Ingredientwt100 gXVXVIXVIIXVIIIXIXXX2,2-Methylenebis1220.0516.17(4-chlorophenol)Hexachlorophen...

example 3

Correlation of Results with Partition Coefficients (Pc)

Pc is defined as the calculated octanol-water partition coefficient. The log Pc values are calculated using two methods. The first method uses Alchemy 2000 Molecular Modeling Software (Tripos) along with a data set developed by STERIS Corporation. The second method uses Advanced Chemistry Development (ACD) Software Solaris v4.67 (© 1994-2002 ACD). The calculated log Pc values for each phenol are shown in TABLE 3: These values are compared with Log reduction colonies obtained in Example 2.

TABLE 3Log Pc(AlchemyLog10 ReductionPhenol2000)Log Pc (ACD)of ColoniesPhenol1.391.483.6p-Cresol2.081.943.72,3-Dimethylphenol2.502.404.1p-Chloro-m-cresol2.582.894.3p-Chloro-m-xylenol3.053.354.42,4,5-Trichlorophenol3.233.714.9Thymol3.273.283.2o-Phenylphenol3.402.944.82,2-Methylenebis(4-4.274.623.8chlorophenol)o-Benzyl-p-chlorophenol4.324.414.7Triclosan4.515.822.7Hexachlorophene5.757.203.6

FIG. 1 shows the Log IFDO reduction vs Log Pc (Alchemy 2...

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Abstract

A method of decontaminating a surface or liquid which is contaminated with prions includes treating the surface with a composition which includes one or more phenol. Phenols which are particularly effective include p-chloro-m-xylanol, thymol, triclosan, 4-chloro, 3-methylphenol, pentachlorophenol, hexachlorophene, 2,2-methyl-bis(4-chlorophenol), and p-phenylphenol.

Description

BACKGROUND OF THE INVENTION The present invention relates to the field of biological decontamination. The invention finds particular application in connection with the removal and / or destruction of harmful biological materials, such as prions (proteinaceous-infectious agents), from medical, dental, and pharmaceutical instruments and will be described with particular reference thereto. It will be appreciated, however, that the method and system of the present invention may be utilized in biological decontamination of a wide range of equipment, instruments, and other surfaces contaminated with prion infected material, such as pharmaceutical preparation facilities, food processing facilities, laboratory animal research facilities including floors, work surfaces, equipment, cages, fermentation tanks, fluid lines, and the like. The term “Prion” is used to describe proteinaceous-infectious agents that cause relatively similar brain diseases in humans and / or in animals, which are invaria...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L2/16A61L2/18A61L2/22A61L2/23
CPCA61L2/18A61L2/23A61L2/22A61L2/16
Inventor MCDONNELL, GERALD E.KAISER, HERBERT J.ANTLOGA, KATHLEEN M.KELLER, SHAHIN
Owner AMERICAN STERILIZER CO
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