Compositions and methods for treatment of cancer

a technology of adhesion protein and peptide, which is applied in the field of animal cell adhesion protein peptidomimetics, can solve the problems of long time-consuming and laborious treatment of cancer, affecting the development of anti-adhesion therapy for the treatment of disease processes for which there is no effective treatment, and affecting the study of these processes. it can reduce the adhesion of tumor cells and reduce the metastasis of cancer
US20050181987A1Inactive Publication Date: 2005-08-18THE WISTAR INST OF ANATOMY & BIOLOGY +1
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
THE WISTAR INST OF ANATOMY & BIOLOGY
Publication Date
2005-08-18
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compositions containing one or more peptido-mimetics or modified peptido-mimetics of a carbohydrate ligand of an adhesion molecule in a physiologically acceptable carrier are useful for methods of reducing metastasis in a mammal and for inhibiting inflammatory response in a mammal. Particularly useful are embodiments in which the ligand is a Lewis antigen and / or the adhesion molecule is a selectin, e.g., E-selectin. Methods are disclosed for identifying peptido-mimetics of carbohydrate ligands, which may be involved in binding of tumor cells to other cells, such as endothelial cells.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 09 / 831,047, filed May 3, 2001, which is a 371 of International Patent Application No. PCT / US99 / 26277, filed Nov. 5, 1999, which claims the benefit of the priority of U.S. Provisional Patent Application No. 60 / 107,478, filed Nov. 6, 1998, now abandoned.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] This invention was supported in part by funds from the U.S. Government (United States Army Grant DAMD 17-96-1-6232 and NIH Grant No. A145133). The U.S. Government may therefore have certain rights in the invention.BACKGROUND OF THE INVENTION

[0003] The invention relates generally to animal cell adhesion, and more specifically to peptido-mimetics of carbohydrate ligands of animal cell adhesion proteins and methods of using the same.

[0004] Tumor metastasis is a multistep process requiring detachment of malignant cells from the primary tumor, penetrati...

Claims

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