Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue

US20060073124A1Inactive Publication Date: 2006-04-06AUTONOMOUS UNIVERSITY OF MADRID +1

Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
AUTONOMOUS UNIVERSITY OF MADRID
Publication Date
2006-04-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods for the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, this invention relates to an adult multipotent cell or a cell population or composition comprising said cell, isolated from non-osteochondral mesenchymal tissue, characterized in that the cell is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.
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Description

BACKGROUND OF THE INVENTION

[0001] Stem cells show differential characteristics as they are able to sustain themselves and differentiate into one or more cell type. Although research into stem cells and their applications is still in its early stages, adult stem cells in bone marrow have been used in transplants for more than 30 years. Nevertheless, in recent years, stem cell technology has made large advances such that stem cells are currently considered as a promising source of tissue and organs, with an important therapeutic potential for repair and regeneration of tissues.

[0002] The use of stem cells is an alternative therapy for several human diseases, particularly those in which there is a loss of functional cells, including chondral, bone and muscular lesions, neurodegenerative diseases, immunologic rejection, heart disease and skin disorders (see U.S. Pat. Nos. 5,811,094, 5,958,767, 6,328,960, 6,379,953, 6,497,875).

[0003] In addition to cell therapy applications, stem cell...

Claims

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