Topographic genotyping for determining the diagnosis, malignant potential, and biologic behavior of pancreatic cysts and related conditions
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- REDPATH INTEGRATED PATHOLOGY INC
- Publication Date
- 2006-04-27
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
REFERENCE TO RELATED APPLICATIONS
[0001] This application claims benefit of U.S. Provisional Application No. 60 / 620,926 filed Oct. 22, 2004, 60 / 631,240 filed Nov. 29, 2004, 60 / 644,568 filed Jan. 19, 2005, 60 / 679,968 filed May 12, 2005, and 60 / 679,969 filed May 12, 2005 which are incorporated herein in their entirety for all purposes.FIELD OF THE INVENTION
[0002] The application relates to a method of a predicting the presence of invasive pancreatic cancer, high grade dysplasia, pre-cancerous pancreatic states and alternative neoplastic and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis, and a broad spectrum of tumor suppressor gene linked microsatellite loss of heterozygosity. The application provides a means to clearly separate cancer from non-cancer states such as those produced by inflammation, infection and trauma involving the pancreas. Methods of diagnosing, determining prognosis of, and determ...