Use of parathyroid hormone-related protein (PTHrP) in the diagnosis and treatment of chronic lung disease and other pathologies

a parathyroid hormone and related protein technology, applied in the field of chronic lung disease, can solve the problems of disability, death, disability, etc., and achieve the effect of increasing the stability and half-life of such molecules and facilitating the addition of additional moieties

Inactive Publication Date: 2006-04-27
LOS ANGELES BIOMEDICAL RES INST AT HARBOR UCLA MEDICAL CENT
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lack of adequate gas exchange leads to disability which can progress to death.
Diseases that result in fewer alveoli and / or the deflation of alveoli therefore are quite serious, and are common causes of inadequate oxygenation and frequently resultant in disability and death.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of parathyroid hormone-related protein (PTHrP) in the diagnosis and treatment of chronic lung disease and other pathologies
  • Use of parathyroid hormone-related protein (PTHrP) in the diagnosis and treatment of chronic lung disease and other pathologies
  • Use of parathyroid hormone-related protein (PTHrP) in the diagnosis and treatment of chronic lung disease and other pathologies

Examples

Experimental program
Comparison scheme
Effect test

example 1

The Role of Fibroblast Transdifferentiation in Pulmonary Alveolar Epithelial Growth, Differentiation and Repair

[0254] Parathyroid Hormone-related Protein (PTHrP) expression is necessary for the differentiation the mesenchymal lipofibroblast, which induces epithelial type II (TII) cell differentiation, both of which are vital for alveolar homeostasis. Furthermore, PTHrP deficiency is associated with chronic lung disease (CLD) and failed alveolarization in the preterm baboon model of bronchopulmonary dysplasia. Experimentally, PTHrP deficiency causes the transdifferentiation of lipofibroblasts to myofibroblasts, characterized by loss of PTHrP receptor expression, decreased ADRP expression and triglyceride content, and up-regulation of alpha SMA. PTHrP treatment of transdifferentiating lipofibroblasts reverses the down-regulation of the PTHrP receptor and up-regulation of ∀SMA, returning these cells to a lipofibroblast genotype. When TII alveolar cells are co-cultured with lipofibrobl...

example 2

Hyperoxia Enhances Pulmonary Lipofibroblast-to-Myofibroblast Transdifferentiation

[0290] Bronchopulmonary dysplasia (BPD) remains a major cause of morbidity and mortality in premature infants, and despite many advances its pathophysiology remains incompletely understood. Exposure of the premature lung to hyperoxia is commonly implicated in its pathogenesis. However, the exact link between hyperoxia and BPD, and particularly its role in the generation of myofibroblasts, the signature cell type of lung fibrosis, is not clear. There is increasing evidence that lipid interstitial fibroblasts play an important role in the injury-repair mechanisms in various organ systems. In this study we demonstrate that exposure to hyperoxia enhances the transdifferentiation of pulmonary lipofibroblasts to myofibroblast. Fetal rat lung fibroblasts (FRLF) from e (embryonic, term=22) 18 and e21 were studied. After initial culture in MEM and 10% FBS in 21% O2+5% CO2 at 37° C., FRLFs were maintained in MEM...

example 3

Oxygen-Induced Metabolic Changes and Transdifferentiation in Immature Fetal Rat Lung Lipofibroblasts

[0317] Preterm infants lack adequate surfactant production and often require oxygen support for adequate oxygenation. Prolonged oxygen treatment leads to the development of bronchopulmonary dysplasia (BPD), a disease process characterized by the blunting of alveolarization and proliferation of myofibroblasts. In the present study, we investigated metabolic adaptive changes in cultured fibroblasts isolated from immature (d18) and near-term (d21) fetal rat lungs in response to normoxic (21%) and hyperoxic (95%) exposures. We used the [1,2-13C2]-D-glucose tracer and gas chromatography / mass spectrometry to characterize glucose carbon redistribution between the nucleic acid ribose, lactate, and palmitate synthetic pathways, and reverse transcriptase-polymerase chain reaction to assess Adipose Differentiation Related Protein mRNA expression in response to hyperoxic exposure. Exposure to hy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
partial pressureaaaaaaaaaa
Tmaaaaaaaaaa
radial elongationaaaaaaaaaa
Login to view more

Abstract

This invention pertains to the discovery that Parathyroid Hormone-related Protein (PTHrP) can be detect and / or stage, and / or treat chronic lung diseases. In particular, it was discovered that PTHrP levels in broncho-alveolar lavage are indicative of lung “health” and “disease, and can be used to predict lung disease in patients at risk of chronic lung disease and / or to evaluate the efficacy of a ventilation regime.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation-in-part of U.S. Ser. No. 10 / 352,768, filed on Jan. 27, 2003, which claims priority to and benefit of U.S. Ser. No. 60 / 377,665, filed on May 2, 2002, and U.S. Ser. No. 60 / 421,615, filed on Oct. 25, 2002, all of which are incorporated herein by reference in their entirety for all purposes.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This work was supported, in part, by Grant No: HL55268 from the National Heart, Lung and Blood Institute of the National Institutes of Health. The government of the United States of America may have certain rights in this invention.FIELD OF THE INVENTION [0003] This invention pertains to the field of chronic lung disease. In particular this invention pertains to the discovery that Parathyroid Hormone-related Protein (PTHrP) can be used to detect and / or stage, and / or treat chronic lung diseases BACKGROUND OF THE INVENTION ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/557A61K31/4439A61K31/426
CPCC12Q1/6883G01N33/78G01N2333/635G01N2800/12G01N2800/52C12Q2600/158
Inventor TORDAY, J.REHAN, VIRENDERMINK, RICHARD
Owner LOS ANGELES BIOMEDICAL RES INST AT HARBOR UCLA MEDICAL CENT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap