Devices and methods to image objects by time delay integration

a technology of time delay and image objects, applied in the field of devices and methods to image objects by time delay integration, can solve the problems of insufficient sensitivity of other currently available methodologies for accurate classification and typing of rare events such as circulating tumor cells, and lack of evidence, so as to improve detection, enumeration and classification, and avoid cell loss. , the effect of high quality fluorescence images
US20060147901A1Inactive Publication Date: 2006-07-06JANSSEN DIAGNOSTICS LLC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
JANSSEN DIAGNOSTICS LLC
Publication Date
2006-07-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected to Time Delay Integration imaging (TDI). Incorporation of TDI technology into image cytometry analysis, like CellTracks®, makes it possible to image moving objects with very high sensitivity and signal-to-noise ratios. Implementation of TDI camera technology with dual excitation and multispectral imaging of enriched rare cells provides a rapid system for detection, enumeration, differentiation and characterization of imaged rare cells on the basis of size, morphology and immunophenotype.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority to U.S. application Ser. No. 10 / 612,144, and U.S. Provisional Application No. 60 / 494,101, filed 11 Aug. 2003, under 35 U.S.C. section 119 (e). The entire disclosure of which is incorporated by reference herein.TECHNICAL FIELD

[0002] This invention relates generally to devices and methods to obtain to scan and obtain images of objects, and more particularly to images reconstructed from partial sub-images of object such as cells obtained from biological fluids that are distributed in a two-dimensional plane. The scanning and imaging technique provided by the invention is especially advantageous for the imaging of cells that are aligned by magnetic means and examined by digitized optoelectronic means through Time-Delay-Integration. BACKGROUND OF THE INVENTION

[0003] The identification and enumeration of circulating carcinoma cells of epithelial origin in the blood of cancer patients that may be present at f...

Claims

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