Chaperone expression genomes

a technology of genomes and chaperones, applied in the field of chaperone expression genomes, can solve the problem of inability to control the expression ratio of foreign proteins in individual cells, and achieve the effects of facilitating co-translocation, and improving the folding of a protein of interes
US20080057538A1Inactive Publication Date: 2008-03-06BELYAEV ALEXANDER S
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BELYAEV ALEXANDER S
Publication Date
2008-03-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

A recombinant genome comprising polynucleotides encoding at least two additional molecular chaperones and a protein of interest, recombinant baculovirus vectors providing molecular chaperones and a method for producing a foreign protein using said genomes and vectors.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation application of U.S. application Ser. No. 10 / 898,717 filed Jul. 23, 2004, now issued as U.S. Pat. No. 7,226,781; which claims the benefit under 35 USC § 119(e) to U.S. Application Ser. No. 60 / 490,350 filed Jul. 24, 2003, now abandoned. The disclosure of each of the prior applications is considered part of and is incorporated by reference in the disclosure of this application.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention

[0003] This invention relates in general to a genome expressing additional molecular chaperones simultaneously with a protein of interest in order to assure better folding of a protein of interest.

[0004] 2. Background Information

[0005] High level expression of proteins, such as for use as biopharmaceuticals, requires proper protein folding for optimal biological activity. Overexpressed proteins are often misfolded and form biologically inactive insoluble protein aggregat...

Claims

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