N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase

a technology of indoleamine and hydroxyamidinoheterocycles, which is applied in the direction of biocide, drug composition, immunological disorders, etc., can solve the problems of quinolinic acid (quin), kynurenine metabolites such as 3-hydroxy-kynurenine, and inability of fetus to fully explain the survival of fetal allografts
US20080125470A1Inactive Publication Date: 2008-05-29INCYTE
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
INCYTE
Publication Date
2008-05-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Ser. No. 60 / 845,700, filed Sep. 19, 2006, the disclosure of which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION

[0002] The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.BACKGROUND OF THE INVENTION

[0003] Tryptophan (Trp) is an essential amino acid required for the biosynthesis of proteins, niacin and the neurotransmitter 5-hydroxytryptamine (serotonin). The enzyme indoleamine 2,3-dioxygenase (also known as INDO or IDO) catalyzes the first and rate limiting step in the degradation of L-tryptophan to N-formyl-kynurenine. In human cells, a depletion of Trp resulting from IDO activity is a prominent gamma interferon (IFN-γ)-inducible antimicrobial effector mechanism. IFN-γ stimulation induces activation of IDO, which leads to a depletion of Trp, thereby arresting the growth of Trp-...

Claims

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