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Oral Compositions and Route of Administration for the Delivery of a Thylakoid Extract

a technology of thylakoid extract and oral composition, which is applied in the directions of magnoliophyta medical ingredients, plant ingredients, biocide, etc., can solve the problem that no data have confirmed the potential use of thylakoid extract as an oral anti-oxidative, and achieve the effect of preventing oxidative damage to components

Inactive Publication Date: 2008-11-06
PURECELL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]Therefore, in accordance with the present invention is provided a use of purified thylakoids in the making of an oral composition for treating or preventing a disease or disorder involving the formation of reactive oxygen species or inflammation.
[0010]Further is provided the use of purified thylakoids in the making of an oral composition for preventing oxidative damages to components of the composition. In a specific embodiment, the oral composition is food or a food supplement. In another embodiment, the oral composition is a medication against oxidative damages, disorders or diseases.
[0017]Excipients and carriers are widely used in the pharmaceutical field and are known to those skilled in the art. Amongst them, binding agents, disintegrating agents and / or fillers are of current use. The form taken by the product may also vary widely. Dry products comprise pellets, and powders and granules in a free form or in capsules. Liquid products may comprise lipids (oils and fats), stabilizers, emulsifiers, surfactants, polymers, and / or any colorant or flavoring additive to improve the taste, the scent or the appearance of the composition.

Problems solved by technology

However, today, no data has confirmed the potential use of the thylakoid extract as an oral anti-oxidative and / or anti-inflammatory agent.

Method used

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  • Oral Compositions and Route of Administration for the Delivery of a Thylakoid Extract
  • Oral Compositions and Route of Administration for the Delivery of a Thylakoid Extract
  • Oral Compositions and Route of Administration for the Delivery of a Thylakoid Extract

Examples

Experimental program
Comparison scheme
Effect test

example 1

The Thylakoids are Active as Enteral and Oral Compounds

Methodology

Animals

[0031]Male Wistar rats (180-200 g) were used in the experiments. The animals were purchased from Charles River Canada (St-Constant, Qc, Canada). The animals were housed in an environmentally (t=25° C.) and air humidity (60%) controlled room with a 12 h light-dark cycle, kept on a standard laboratory diet and drinking water ad libitum. The experiments were approved by the ethical committee of TransBIOTech (Levis, Qc, Canada).

Reagents

[0032]12-O tetradecanoyl phorbol 13-acetate (TPA, P-8139) and carrageenan (C-1138) were purchased from Sigma Chemical Co. (St-Louis, Mo., USA).

Preparation of the Thylakoid Extract

[0033]The thylakoid extract was obtained from spinach leaves (Spinacia oleacea) as described in International patent publication WO 01 / 49305, the whole content of which is incorporated herein by reference. The thylakoids integrity was evaluated by spectrophotometry (Beckman DU 640) (Lichtenthale 1987) and fl...

example 2

The Thylakoid Extract can be Formulated as a Product for Oral Use

Materials and Methods

Materials

[0043]Three commercially available polymers were used for this study sodium alginate, carboxymethyl cellulose low viscosity (CMC1) and carboxymethyl cellulose high viscosity (CMC2). The complex PCT was given by PureCell Technologies inc.

PCT Stability to Compression

[0044]First of all, PureCell Technologies inc. PTC was compressed as such, with any excipient, in order to evaluate the capacity of PCT to preserve its biological activity, following compression. Tablets of 200 mg made from PCT only were obtained by dry compression at 1, 2.5 and 5 T in a Carver hydraulic press using a punch of 9 mm diameter. The obtained tablets were broken down to powder and sent to PureCell Technologies inc. where the complex activity was tested.

PCT Stability to Compression in Presence of Polymeric Excipients

[0045]Tablets of 200 mg based on, one of the three polymers (alginate, CMCJ or CMC2) containing 20, 40 o...

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PUM

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Abstract

The present invention provides a new use for a thylakoid extract, that is for oral route of administration, and a composition comprising the thylakoid extract in adjunction with an acceptable carrier for oral administration. Besides the pharmaceutical use, the thylakoid extract enters the composition of food or food supplements, for its inocuity and its capacity to provide a diet enriched in anti-oxidants and anti-inflammatory compounds. Therefore, in accordance with the present invention is provided the use of a thylakoid extract in the making of an oral composition for treating or preventing a disease or disorder involving the formation of reactive oxygen species or inflammation. Also is provided a method for treating or preventing a disease or disorder involving the formal of reactive oxygen species or inflammation in an individual, which comprises the step of orally administering an effective dose of a thylakoid extract. Further is provided an oral composition comprising a thylakoid extract and a vehicle for oral ingestion or oral administration. An oral composition comprising purified thylakoids and a carrier for oral ingestion or oral administration, with the proviso that the carrier does not essentially consists of water, physiological saline or propylene glycol is also provided as food or a food supplement, or as a pellet, or encapsulated granules or powder. The carrier may be present in an amount of 0.01% to 95% (w / w) of the total composition. The purified thylakoids are present in an amount which achieves a dosage of 0.1 to 10 mg per Kg of a subject's body weight.

Description

FIELD OF THE INVENTION[0001]This invention relates to oral administration of a thylakoid extract or of compositions comprising same.BACKGROUND OF THE INVENTION[0002]Thylakoids are specialized membranes that are responsible for photosynthesis in eukaryotes (plant & algae) and prokaryotes cells (bacteria). These photosynthetic organisms convert CO2 to organic material by reducing this gas to carbohydrates in a complex set of reactions. Electrons for this reduction reaction ultimately come from water, which is then converted to oxygen and protons. Energy for this process is provided by light, which is absorbed by pigments (primarily chlorophylls and carotenoids).[0003]The initial electron transfer (charge separation) reaction in the photosynthetic reaction center sets into motion a long series of redox (reduction-oxidation) reactions, passing the electron along a chain of cofactors and filling up the “electron hole” on the chlorophyll, much like in a bucket brigade. All photosynthetic ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/18A61P29/00A23L1/30A61K35/66A61K36/00A61P39/06
CPCA23V2002/00A61K36/21A23L1/3002A61K36/00A23L33/105A61P29/00A61P39/06A61K9/0053
Inventor PURCELL, MARCDROUIN, REJEAN
Owner PURECELL TECH
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