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Method of selecting antioxidants for use in topically applied compositions

Inactive Publication Date: 2009-07-30
MSD CONSUMER CARE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0011]The invention further provides for a composition for topical application, wherein the composition comprises at least one antioxidant compound that substantially inhibits ultraviolet radiation-induced reactive oxygen species formation in the upper layers of the epidermis and at least one antioxidant compound that substantially inhibits ultraviolet radiation-induced reactive oxygen species formation in the lower layers of the epidermis.

Problems solved by technology

However, research has shown that even sub-erythemal doses of UVR generates such an abundance of ROS that skin's own antioxidant defenses become overwhelmed, resulting in a build up of ROS that are free to cause oxidation, which contributes to acute (immunosuppression and photosensitivity disorders) and chronic (photoaging and skin cancer) forms of skin damage (Thiele J J, et al.

Method used

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  • Method of selecting antioxidants for use in topically applied compositions
  • Method of selecting antioxidants for use in topically applied compositions
  • Method of selecting antioxidants for use in topically applied compositions

Examples

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example formulations

[0126]Example sunscreen formulations are prepared according to the methods described herein with the following ingredients:

TABLE 17IngredientAmount, % w / wPurified Water45.0-90.0Homosalate 5.0-15.0Octocrylene2.0-10 Oxybenzone0.5-6.0Octisalate5.0Avobenzone1.0-3.0Prolipid 1412.0-7.0Butylene Glycol2.0-7.0Microcrystalline Cellulose / 0.2-5.0CarboxymethylcelluloseBenzyl Alcohol0.5-2.0Vitamin E0.01-3.0 Diethylhexyl syrigylidene malonte0.01-6.0 Phylanthus Emblica fruit extract0.01-1.0 Green Tea Extract0.01-1.0 Disodium Lauriminodiproprionate0.3-3.0Tocopheryl PhosphatesChlorphenesin .10-0.20Butylated PVP.05-.50Disodium EDTA0.01-.20  Sodium Ascorbyl Phosphate.01-1.0Vitamin A Palmitate.01-1.0

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Abstract

Antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. Methods for testing a composition for ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum. Compositions and methods for treating and preventing photodamage to skin.

Description

[0001]This application claims priority to U.S. Provisional Application Nos. 61 / 023,713, filed Jan. 25, 2008, and 61 / 114,758, filed Nov. 14, 2008.FIELD OF THE INVENTION[0002]This invention relates generally to compositions applied topically to skin and hair for protection against ultraviolet radiation. The invention also relates to methods of selecting antioxidants for inclusion in such compositions.BACKGROUND OF THE INVENTION[0003]Exposure of skin to ultraviolet radiation (UVR) induces formation of free radicals and oxidants (singlet oxygen, hydroxy radical, hydrogen peroxide, peroxynitrite, superoxide anions, etc.) collectively referred to as reactive oxygen species (ROS) (Hanson K M, Clegg R M. Photochemistry and Photobiology, 2002, 76(1): 57-63; Black H S. Photochem. Photobiol. 1987, 46, 213-221). Formation of UV-induced ROS causes oxidative damage to lipids, proteins and DNA (Vile G F and Tyrrell R M. Free Radic. Biol. Med, 1995, 18, 721-722; Chen Q, et al. Proc. Natl. Acad. Sci...

Claims

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Application Information

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IPC IPC(8): G01N21/64C12Q1/02A61K8/00A61K8/368G01J1/58
CPCA61K8/37A61K8/678A61K8/97C12Q1/025A61Q17/04G01N33/5082A61K49/00A61K2800/522A61K8/9789A61K8/9794A61P17/00A61P17/02A61P17/16A61P39/06G01N33/502G01N33/5088G01N33/92
Inventor MEYER, THOMAS A.BEASLEY, DONATHAN G.
Owner MSD CONSUMER CARE INC
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