Method of selecting antioxidants for use in topically applied compositions

Inactive Publication Date: 2009-07-30
MSD CONSUMER CARE INC
View PDF5 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]The present invention provides a method for confirming antioxidant activity of a composition formulated for topical application to skin, wherein the method comprises testing the composition for ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation throughout the epidermis.
[0009]The invention also provides a method for screening compounds for antioxidant behavior in a composition to be topically applied to skin, wherein the screening method comprises determining the compound's ability to inhibit both ultraviolet radiation-induced skin lipid hydroperoxide formation and ultraviolet radiation-induced reactive oxygen species formation throughout the epidermis.
[0010]This invention also provides a composition for applica

Problems solved by technology

However, research has shown that even sub-erythemal doses of UVR generates such an abundance of ROS that skin's own antioxidant defenses become overwhelmed, resulting in a build up of ROS th

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of selecting antioxidants for use in topically applied compositions
  • Method of selecting antioxidants for use in topically applied compositions
  • Method of selecting antioxidants for use in topically applied compositions

Examples

Experimental program
Comparison scheme
Effect test

example formulations

[0126]Example sunscreen formulations are prepared according to the methods described herein with the following ingredients:

TABLE 17IngredientAmount, % w / wPurified Water45.0-90.0Homosalate 5.0-15.0Octocrylene2.0-10 Oxybenzone0.5-6.0Octisalate5.0Avobenzone1.0-3.0Prolipid 1412.0-7.0Butylene Glycol2.0-7.0Microcrystalline Cellulose / 0.2-5.0CarboxymethylcelluloseBenzyl Alcohol0.5-2.0Vitamin E0.01-3.0 Diethylhexyl syrigylidene malonte0.01-6.0 Phylanthus Emblica fruit extract0.01-1.0 Green Tea Extract0.01-1.0 Disodium Lauriminodiproprionate0.3-3.0Tocopheryl PhosphatesChlorphenesin .10-0.20Butylated PVP.05-.50Disodium EDTA0.01-.20  Sodium Ascorbyl Phosphate.01-1.0Vitamin A Palmitate.01-1.0

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Login to view more

Abstract

Antioxidant-containing compositions and methods for confirming antioxidant activity of a composition formulated for topical application to skin. Methods for testing a composition for ability to inhibit both ultraviolet radiation-induced lipid peroxidation on skin and ultraviolet radiation-induced reactive oxygen species formation in the stratum corneum. Compositions and methods for treating and preventing photodamage to skin.

Description

[0001]This application claims priority to U.S. Provisional Application Nos. 61 / 023,713, filed Jan. 25, 2008, and 61 / 114,758, filed Nov. 14, 2008.FIELD OF THE INVENTION[0002]This invention relates generally to compositions applied topically to skin and hair for protection against ultraviolet radiation. The invention also relates to methods of selecting antioxidants for inclusion in such compositions.BACKGROUND OF THE INVENTION[0003]Exposure of skin to ultraviolet radiation (UVR) induces formation of free radicals and oxidants (singlet oxygen, hydroxy radical, hydrogen peroxide, peroxynitrite, superoxide anions, etc.) collectively referred to as reactive oxygen species (ROS) (Hanson K M, Clegg R M. Photochemistry and Photobiology, 2002, 76(1): 57-63; Black H S. Photochem. Photobiol. 1987, 46, 213-221). Formation of UV-induced ROS causes oxidative damage to lipids, proteins and DNA (Vile G F and Tyrrell R M. Free Radic. Biol. Med, 1995, 18, 721-722; Chen Q, et al. Proc. Natl. Acad. Sci...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N21/64C12Q1/02A61K8/00A61K8/368G01J1/58
CPCA61K8/37A61K8/678A61K8/97C12Q1/025A61Q17/04G01N33/5082A61K49/00A61K2800/522A61K8/9789A61K8/9794A61P17/00A61P17/02A61P17/16A61P39/06G01N33/502G01N33/5088G01N33/92
Inventor MEYER, THOMAS A.BEASLEY, DONATHAN G.
Owner MSD CONSUMER CARE INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap