Methods and Nutritional Formulations to Increase the Efficacy and Reduce the Side Effects of Cancer Treatment

a cancer treatment and side effect technology, applied in the field of diet and cancer treatment, can solve the problems of limiting the intensity, frequency and efficacy of chemotherapy, and cannot be combined with chemotherapy nor applied alone, and achieve the effects of reducing weight, reducing cancer growth or a symptom of cancer, and reducing side effects of chemotherapy

Inactive Publication Date: 2011-05-19
UNIV OF SOUTHERN CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]Against this prior art background, a method for alleviating cancer growth or a symptom of cancer is provided. The method of this embodiment includes a step in which a patient with cancer is identified and then provided with a first diet for a first predetermined period of time. The first diet provides the patient with at most 50% of the patient's normal caloric intake with at least 50% of the kilocalories being derived from fat, preferably monounsaturated. The patient is then provided with a second diet for a second predetermined period of time. The second diet provides the patient with at most 500 kcal / day. The patient is then provided with a third diet that optimizes weight regain and the replenishment of essential nutrients required for optimal recovery and health of normal cells and organs. The present embodiment provides a short-term modified diet protocol that is effective in protecting normal cells and impeding and retarding cancer cell growth. The protocol and modified diet will promote these effects without causing chronic weight loss in patients,

Problems solved by technology

However, toxic side-effects to normal cells and tissues limits chemotherapy dose intensity, frequency, and efficacy.
Calorie restriction has also been shown to delay cancer growth, but its effect is small and it cannot be combined with chemotherapy nor can it be applied alone, since it requires a long-term weight loss which is detrimental to cancer patients and also very difficult to maintain.

Method used

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  • Methods and Nutritional Formulations to Increase the Efficacy and Reduce the Side Effects of Cancer Treatment
  • Methods and Nutritional Formulations to Increase the Efficacy and Reduce the Side Effects of Cancer Treatment
  • Methods and Nutritional Formulations to Increase the Efficacy and Reduce the Side Effects of Cancer Treatment

Examples

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experiment 1

[0105]Ten cases are described in which patients diagnosed with a variety of malignancies have voluntarily fasted prior to (48-140 hours) and / or following (24-56 hours) chemotherapy. None of these 10 patients, who received an average of 4 cycles of chemotherapy in combination with fasting, reported significant side effects caused by the fasting itself other than hunger. Toxicity was graded based on the Common Toxicity Criteria (CTC) of the National Cancer Institute (NCI) and self-reported side-effects from five patients indicate that fasting may protect against fatigue, weakness, and gastrointestinal side effects. In those patients whose cancer progression could be monitored, fasting did not prevent the chemotherapy-dependent reduction of tumor mass or tumor markers. Although controlled clinical trials are required to determine the role of fasting in the enhancement of clinical outcomes and the patient's quality of life, the 10 cases presented here suggest that fasting in combination...

case 1

[0107]A 51-year-old Caucasian woman diagnosed with stage HA breast cancer to whom adjuvant chemotherapy with docetaxel (DTX) and cyclophosphamide (CP) was recommended. She fasted prior to her first chemotherapy administration. The fasting regimen consisted of a complete caloric deprivation for 120 hours prior and 60 hours after chemotherapy (180 hours total), during which she consumed only water and vitamins. The patient completed this prolonged fasting without major inconvenience and lost 7 pounds which were recovered by the end of the treatment (Figure IH). After the fasting-chemo cycle, the patient experienced mild fatigue, dry mouth and hiccups (FIG. 2); nevertheless she was able to carry her daily activities (working up to 12 hours a day). By contrast, in the subsequent chemo-treatment cycles (second and third), she received chemotherapy without fasting and complained of moderate to severe fatigue, weakness, nausea, abdominal cramps and diarrhea (FIG. 2). This time the side eff...

case 2

[0108]A 68-year-old Caucasian male who was diagnosed in February 2008 with esophageal adenocarcinoma. By the time of diagnosis, metastasis to the left adrenal gland was found on a CT-PET scan, consistent with stage IV disease. The initial treatment was 5-fluorouracil (5-FU) combined with cisplatin (CDDP). Concurrently with this chemotherapy, he also received localized radiation for the first two cycles. Throughout this period the patient experienced multiple side effects including severe weakness, remarkable fatigue, intense vomiting and significant peripheral neuropathy (FIG. 3). Additionally, the patient complained of intense dysphagia secondary to severe mucositis, most likely caused by the radiation treatment. During the third cycle, 5-FU administration had to be withdrawn due to severe nausea and refractory vomiting (FIG. 3). In spite of the aggressive approach with chemotherapy and radiation, his disease progressed. Development of new metastases to the right adrenal gland, low...

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Abstract

The present invention relates to methods of protecting patients and sensitizing cancer cells in combination with chemotherapy and/or radiation therapy. More specifically, the invention provides nutritional methods and formulations that are capable of reducing cancer growth without causing chronic weight loss in patients, protecting normal cells, tissues and organs from chemotherapy and/radiation therapy, and sensitizing cancer cells against low, normal and high-dose chemotherapy. Some of the methods also impede cancer growth even without chemotherapy.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. provisional Application No. 61 / 254,154 filed Oct. 22, 2009, the disclosure of which is incorporated in its entirety by reference herein.TECHNICAL FIELD[0002]The present invention relates in general to diet and cancer treatment. More specifically, the invention provides methods that may be used to sensitize cancer cells to chemotherapy drugs, while protecting normal cells.BACKGROUND[0003]Chemotherapy can extend survival in patients diagnosed with a wide range of malignancies. However, toxic side-effects to normal cells and tissues limits chemotherapy dose intensity, frequency, and efficacy. For instance, the cardiotoxicity and nephrotoxicity associated with the widely prescribed anti-cancer drugs, doxorubicin and cisplatin, respectively, limit their full therapeutic potential (Rajagopalan, S. Cancer Res. 1988; Hale, J. P. Arch. Dis. Child 1994; Dobyan, D. C., J. Pharmacol. E.T 1980; Fillastre, J....

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N5/00A61K31/704A61K31/675A61K31/7068A61K31/282A61K31/337A61K31/513A61K31/255A61K33/24A61P35/00A61K31/20G09B19/00A23L33/00
CPCA23L1/0067A23L1/3175A61K31/07G06Q10/00A61K31/202A61K31/375A61K31/59A61K31/20A23P20/20A23L13/65A61P3/02A61P35/00A61P43/00
Inventor LONGO, VALTER D.LEE, CHANGHAN
Owner UNIV OF SOUTHERN CALIFORNIA
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