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Interventional drug delivery system and associated methods

a drug delivery and drug technology, applied in the field of interventional drug delivery systems, can solve the problems of significant disadvantages of oral administration of drugs, inability to embed/secure therapeutics in tissue(s) of interest, and existing medical device technologies that enable localized placement of drugs fail to provide the opportunity to embed/secure therapeutics. the effect of high targeted and efficien

Inactive Publication Date: 2011-12-15
LIQUIDIA TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012]As such, embodiments of the present invention are provided to enable highly targeted and efficient delivery of various cargos to predetermined target sites. In this regard, aspects of the present invention provide significant advantages as otherwise detailed herein.

Problems solved by technology

Accordingly, these delivery methods are not optimal for localized targeting of drugs and therapeutic agents to specific internal body tissues.
The delivery of drugs or therapeutic agents by iontophoresis avoids first-pass drug metabolism, a significant disadvantage associated with oral administration of therapeutic agents.
Existing medical device technologies that enable localized placement of therapeutics fail to provide the opportunity to embed / secure therapeutics in the tissue(s) of interest.

Method used

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  • Interventional drug delivery system and associated methods
  • Interventional drug delivery system and associated methods
  • Interventional drug delivery system and associated methods

Examples

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Effect test

example 1

Delivery of Rhodamine 6G Dye into Agarose Phantoms

[0084]A cylindrical tube of 2% (w / v) agarose gel in deionized (D.I.) water was fabricated as a phantom with an outer diameter (o.d.)=2.5 cm and length ˜3-4 cm. A concentric reservoir for holding the dye (o.d=0.8 cm, length ˜2 cm) was cored out from the top surface along the longitudinal axis of the gel cylinder. Electrodes were fabricated out of aluminum foil (width ˜0.5 cm, length ˜15 cm, thickness ˜0.1 cm). A solution of 0.5% Rhodamine 6G in D.I. water was used to model the delivery of a small molecule drug. The dye was filled inside the cored reservoir in the agarose phantom and the source electrode (anode, in this case) was inserted into the dye reservoir. The other end of the anode was hooked to a DC power source with an alligator clip. The agarose phantom was immersed in a beaker containing 0.25×PBS solution, as shown in FIG. 17A. The cathode, a second piece of aluminum foil, was placed in the PBS beside the agarose phantom and...

example 2

Unshielded Electrode Configurations for Control Over Targeted Delivery to Specific In Vivo Locations

[0085]Unshielded electrode configurations were developed for demonstrating control over delivery to specific in vivo locations. These include electrodes fabricated out of metal wire (silver, silver chloride), metal foil (silver, platinum, aluminum) and wire mesh (aluminum), as shown in FIGS. 18A and 18B. These are representative examples, and similar designs can be fabricated with variations in size, material and additional enhancements or refinements to the basic configuration. The advantages of wire and foil electrodes shown FIG. 18A are: simplicity and ease of use, flexibility for insertion into tiny orifices and ducts, precise control over size and potential for miniaturization. Their primary limitation is their tendency for hydrolysis of the conducting fluid medium. Silver electrodes are also susceptible to oxidation, while silver chloride electrodes can get reduced to metallic. ...

example 3

Insulated Electrode Configurations for Control Over Targeted Delivery to Specific In Vivo Locations

[0086]An insulated electrode was developed to demonstrate control over targeted delivery to specific in vivo locations. By insulating a portion of the electrode surface, it is possible to control the delivery to the tissue or organ systems in a well defined fashion. For example, the flux of drug or particles will be attenuated corresponding to the insulated areas of the electrode. Aluminum foil was folded into a long rectangular shape of appropriate dimensions (length ˜10 cm, width ˜0.4 cm, thickness ˜0.1 cm). Insulating tape (width ˜1 cm) was wrapped around the foil in alternating sections. This insulated electrode was immersed in the central reservoir of an agarose phantom (2% agarose w / v in deionized water), as shown in FIG. 19A. A solution of 0.5% Rhodamine 6G in D.I. water was used to model the delivery of a small molecule drug. The dye was filled inside the cored reservoir in the...

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Abstract

A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.

Description

FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0001]This disclosure was partially made with U.S. Government support under contract number CHE-9876674 awarded by the United States National Science Foundation and Technology Center. The U.S. Government may have certain rights in the disclosure.BACKGROUND[0002]1. Field of the Invention[0003]Embodiments of the present invention relate to an interventional drug delivery system, and more particularly, to a system for facilitating delivery of various cargos, such as, for example, therapeutic agents, to target sites of internal body tissue in vivo, and methods associated therewith, wherein the system implements an electric field to drive cargo through tissue as in iontophoretic approaches.[0004]2. Description of Related Art[0005]Many techniques exist for the delivery of drugs and therapeutic agents to the body. Traditional delivery methods include, for example, oral administration, topical administration, intravenous administration, and intramu...

Claims

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Application Information

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IPC IPC(8): A61M5/00A61B6/00
CPCA61B18/1492A61B2018/00214A61N1/327A61N1/306A61B2018/00898A61N1/0428A61N1/325A61K9/0009A61K9/0002A61K9/0024A61L31/16A61N1/00A61N1/044A61N1/0444A61N1/0448A61N1/0507A61N1/05A61N1/30A61N1/303A61N1/36002A61N1/04A61N5/00A61N1/0436A61N1/0476A61N1/18A61N1/0512A61N1/0526A61N1/0514A61N1/0509A61N1/0521A61N1/0529A61N1/0517A61N1/0519A61N1/3601A61N1/36014A61N1/0536A61N1/0548A61N1/0404A61N1/205
Inventor DESIMONE, JOSEPHNAPIER, MARYPILLAI, JONATHANBYRNE, JAMESROUSH, LUKAS MILLERYEH, JEN JENPARROTT, MATT
Owner LIQUIDIA TECH
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