Process for the preparation of (3r,4r)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine

Abstract

The present disclosure is related to an improved and efficient process for preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine which comprises:(a) N-acylation of 3-Amino-4-methyl pyridine; (b) Quarternization of 3-Acetylamino-4-methyl pyridine using benzyl halide; (c) Partial reduction of quarternized 3-Acetylamino-4-methyl pyridine by Sodium borohydride in Methanol or water; (d) Hydrolysis of partially reduced product to 1-Benzyl-4-methylpiperidin-3-one in presence of acid; (e) Reductive amination of 1-Benzyl-4-methylpiperidin-3-one using Methanolic methylamine in presence of Titanium(IV) isopropoxide in Methanol; (f) Resolution of 1-Benzyl-4-methylpiperidin-3-yl)-methylamine using Ditoluoyl (L) tartaric acid to get (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine. The disclosure is also related to novel intermediates:wherein R, R′ and X are as described in the specification.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a divisional of U.S. patent application Ser. No. 14 / 891,028, filed on Nov. 13, 2015, which is U.S. National Phase filing of International Application No. PCT / IB2014 / 066510, filed on Dec. 2, 2014, designating the United States of America and claiming priority to Indian Patent Application No. 3843 / MUM / 2013, filed Dec. 9, 2013, and this application claims priority to and the benefit of the above-identified applications, which are all incorporated by reference herein in their entireties.TECHNICAL FIELD[0002]The present invention provides an efficient and improved process for the preparation of (3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine; a key starting material for the synthesis of 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3 -d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxo-propanenitrile.BACKGROUND OF THE INVENTION[0003]3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxo...

AI Technical Summary

Benefits of technology

This approach results in a more efficient, cost-effective, and environmentally friendly synthesis of (3R,4R)-(1-Benzyl-4-methylpiperidin-3-yl)-methylamine with improved yields and safer conditions, making it suitable for commercial-scale production.

Problems solved by technology

The most important part for the preparation of FORMULA I is the synthesis of (3R,4R)-(1-Benzyl-4-methylpiperidin-3-yl)-methylamine as it is very tedious synthesis and also requires very expensive reagent.

Both the approaches make use of very high chiral catalyst loading and render their commercial use expensive and difficult.

Further, the process requires very high pressure which makes it risky, costlier and unfavorable for scale up.

Overall process yield is very poor i.e. approximately 40%.

Lithium aluminum hydride, a known pyrophoric reagent, account for the safety risk during its manufacturing.

Lastly Platinum oxide is very explosive in presence of hydrogen.

It is very costly reagent which discourages its use on plant scale.

Overall the process is costlier, not so safe to work on commercial scale and demands stringent skill of art.

Use of costly, non safe reagents such as Sodium hydride and lacrimatic Benzyl bromide and Sodium triacetoxyborohydride limit its commercial scale production.

Sealed tube reaction is difficult to execute on large scale.

The processes taught by prior art have several drawbacks namely expensive, not suitable for scale up at plant level, energy intensive, difficult, giving lower yields, forcing use of corrosive acids, longer duration of corrosive reactions and less user friendly.

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