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Oral Compositions and Methods of Use

a technology of oral compositions and oral cavity, applied in the field of oral care compositions, to achieve the effect of maintaining static yield stress and avoiding viscosity loss

Pending Publication Date: 2018-07-26
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The oral care compositions described in this patent can prevent tooth damage and promote healing of ulcers and sores in the mouth. They can also reduce the formation of dental plaque, prevent staining and whitening of teeth, and even help prevent systemic infections via the oral tissues. Additionally, the compositions can maintain their effectiveness over a long period of time, providing consistent and reliable results.

Problems solved by technology

In those instances where additional active ingredients are included and comprise cationic metal ions, e.g. zinc, maintaining the physical stability of the composition is a challenge because of the interaction between these cationic metal ions and certain polymeric components and abrasive systems.

Method used

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  • Oral Compositions and Methods of Use

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0195]The examples herein detail how the viscosity over time for a composition which exhibits a problem of rapid reduction in viscosity (Run A), is compared to five compositions which show the stabilized viscosity provided by the invention (Compositions 1-5 in Table 1).

[0196]Viscosity is measured on a Brookfield HADV2 viscometer using a V74 vane spindle. This viscometer applies a user-controlled angular velocity to the spindle, typically measured in rotations per second (RPM), and reports torque on the shaft of the spindle. Viscosity is then calculated from RPM and torque as explained in the Brookfield Manual (Operating Instructions) using too conversion parameters SRC (shear rate constant) and SMC (spindle multiplier constant). The conversion parameters are defined as follows: SMC=290, SRC=0.2723. The test is performed at room temperature, and varies between 22 and 25° C. During the test, RPM of the spindle is swept from 200 to 0.5 in 12 steps, 10 seconds per step. The viscosity re...

example 2

[0201]Table 5 (below) describes the formulas of three exemplary compositions of the present invention (Compositions 9, 10 and 11) and a comparative example (Comparative Example 1).

TABLE 5CompositionCompositionComparativeComposition 91011Example IIngredientWt %GLYCERIN35.0000026.0000026.0000035.00000SORBITOL - NON-—13.0000013.00000—CRYSTAL - 70% SOLNEP PURIFIED WATER30.9047427.8247427.6247430.84874STANDARD ABRASIVE10.0000010.0000010.0000010.00000SILICASILICA-THICKENER7.000006.000006.000007.00000SMALL PARTICLE5.000005.000005.000005.00000SILICALAURYL SULFATE2.105262.105262.105262.10526GRANULESFlavor1.500001.500001.500001.50000L-ARGININE1.500001.500001.500001.50000COCAMIDOPROPYL1.250001.250001.250001.25000BETAINEZINC OXIDE1.000001.000001.000001.00000TITANIUM DIOXIDE0.750000.750000.75000—XANTHAN GUM0.600000.300000.300000.40000SODIUM CMC - TYPE———1.1000012HYDROXYETHYL-0.500000.800001.00000—CELLULOSE (HEC)*TETRASODIUM0.500000.500000.500000.50000PYROPHOSPHATEZINC CITRATE0.500000.500000.5000...

example 3

[0202]Table 6 (below) describes the results of viscosity and static yield stress evaluations performed on an exemplary composition of the present invention and a reference formula.

[0203]Viscosity and Yield Stress are measured on a Brookfield HADV2 viscometer using V74 vane spindle 1.176 cm in length and 0.589 cm in diameter. This viscometer applies a user-controlled angular velocity to the spindle, typically measured in rotations per second (RPM), and reports torque, T %, measured in the percentage of the maximum total torque on the shaft of the spindle. The torque, T, measured in SI units, N*m, is related to T % as reported by the above mentioned viscometer as T=1.437*10−5*T %.

[0204]The tests are performed at room temperature (22 to 25° C.). During the test 0.5 RPM of the spindle is first rotated for 400 sec and then RPM is swept from 0.5 to 200 and back to 0.5 in 12 logarithmical steps each way, 10 seconds per step. The viscosity reading is taken at RPM=1 on the decreasing RPM swe...

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Abstract

Described herein are oral care compositions comprising an amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a molecular weight of from about 300,000 to about 350,000; and a polysaccharide gum; along with methods of making and using same.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of priority from PCT / CN2016 / 086994, filed Jun. 24, 2016, the contents of which are hereby incorporated by reference in their entirety.BACKGROUND[0002]Arginine-based oral care compositions generally include some combination of polymers, abrasive(s); and in some instances, additional active ingredients. In those instances where additional active ingredients are included and comprise cationic metal ions, e.g. zinc, maintaining the physical stability of the composition is a challenge because of the interaction between these cationic metal ions and certain polymeric components and abrasive systems.[0003]The use of certain abrasives or specific concentrations of particular polymers are two ways in which the stability issues have been addressed. However, these methods have generally been individually focused on stand-up (i.e., appearance on the brush) and squeezability from packaging (toothpaste tubes). As such...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/44A61K8/27A61K8/73A61K8/21A61Q11/00
CPCA61K8/44A61K8/27A61K2800/48A61K8/21A61Q11/00A61K8/731A61K8/24A61K8/25A61K8/365A61Q11/02A61K8/73A61P1/02A61K2800/28A61K2800/52A61K8/042A61K8/34A61K8/37A61K8/442
Inventor POTH, TILOPOTANIN, ANDREIBLANVALET, CLAUDEWON, BETTYMANUS, LISASTRANICK, MICHAEL A.HUANG, XIAOYIPRENCIPE, MICHAELRUSSO, AMYSTETTLER, HANSRUEDIYAN, PENGTAN, CHENGKANGPATEL, VYOMAMORGAN, ANDRE
Owner COLGATE PALMOLIVE CO
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