Method of purifying macrolides

a macrolide and purification technology, applied in the field of purification methods, can solve the problems of undesirable impurities in pharmaceutical compounds, and achieve the effect of reducing the level of impurities and reducing impurities
US7220357B2Inactive Publication Date: 2007-05-22TEVA PHARM USA INC +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
TEVA PHARM USA INC
Publication Date
2007-05-22
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

Provided is a method of purifying a macrolide, especially tacrolimus, that includes loading macrolide onto a bed of sorption resin and elting with a suitable eluent such as a combination of water and tetrahydrofuran.
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Description

RELATED APPLICATIONS

[0001] This application claims the benefits of U.S. provisional application Ser. No. 60 / 490,070, filed Jul. 24, 2003 and U.S. provisional application Ser. No. 60 / 539,363, filed Jan. 26, 2004, the contents of all of which are incorporated herein by reference.

[0002] The present invention relates to a method of purifying macrolides, especially tacrolimus, ascomycin, sirolimus, everolimus, or pimecrolimus, by a separation method using sorption resins.BACKGROUND OF THE INVENTION

[0003] Macrolides are multi-membered lactone rings having one or more deoxy sugars as substituents. Erythromycin, azithromycin, and clarithromycin are macrolides that have bacteriostatic and / or bactericidal activity.

[0004] Tacrolimus (FK 506) is also a macrolide antibiotic that is also an immunosuppressive agent. More potent than cyclosporin, tacrolimus reportedly has a selective inhibitory effect on T-lymphocytes.

[0005] Pimecrolimus is a macrolactam and a ascomycin derivative that reportedly inhibi...

Claims

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