53 results about "Histotripsy" patented technology

The invention relates to the technical field of medical equipment, and provides a focused ultrasound system with multiple treatment modes. The drive circuit comprises a signal generation module which outputs a first ultrasonic generation signal suitable for a thermal ablation mode or a second ultrasonic generation signal suitable for a histotripsy mode; the energy amplification module comprises a signal end, a power supply end and an output end coupled with the ultrasonic transducer; the energy amplification module comprises an isolation driving circuit which outputs a first switch driving signal and a second switch driving signal which are opposite based on an input ultrasonic generation signal; and the power amplification circuit comprises a second switch unit and a first switch unit which are set to be in opposite switch states by opposite driving signals so as to output ultrasonic driving signals to excite the ultrasonic transducer to form focused ultrasound in a histotripsy mode or a thermal ablation mode. The driving circuit is simple in structure and easy to realize, and can meet power supply requirements of various modes such as thermal ablation, histotripsy and the like.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A system and method, including an ultrasound imaging transducer, an ultrasound therapy transducer, a robotic arm configured to orient the ultrasound imaging transducer and the ultrasound therapy transducer about a patient, a display connected to imaging transducer, and a memory, storing instructions that when executed by a processor receive ultrasound images from the imaging transducer, present ultrasound images, receive an input to alter a shape of a contour line, present the contour line, receive an input of a size of a margin around the treatment area, present the margin, determine end points at locations where X, Y, and Z axes bisect the contour line in an XZ plane and a YZ plane, drive the ultrasound therapy transducer to a location where a focal point of the ultrasound therapy transducer is at the end point, and determining whether a resistance to movement exceeds a threshold.

Systems and techniques are provided for generating histotripsy therapy pulses using full cycle transmit. An ultrasonic system may include a transducer array and amplifier electronics. The transducer array may include transducer elements. The transducer elements may be positioned on the transducer array such that the separation between neighboring transducer elements of the transducer elements in both elevation and azimuth is no more than one wavelength of the ultrasonic center frequency of the transducer array. The amplifier electronics may drive the transducer array.

A fluidic acoustic coupling system configured for management of fluids in histotripsy therapy is provided, which may include any number of features. Provided herein are systems and methods that provide management and control of fluid delivery and drainage of reservoirs within a fluidics cart of a histotripsy system. Additional embodiments are provided herein.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are histotripsy and / or ultrasound transducer arrays, and associated systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The transducer arrays provided herein can include a machined array shell having a plurality of wells formed therein. An acoustic stack including a plurality of matching and transducer elements can be disposed in the wells and be configured to transmit ultrasound energy through the plurality of matching layers and through the array shell towards a common focal point

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

A system and method for rendering a diseased organ implant eligible, the method including acquiring an image data set of a potential donor organ, identifying one or more disease states in the potential donor organ, wherein the one or more disease states render the organ ineligible for transplant, harvesting the potential donor organ, applying histotripsy therapy, and confirming elimination / reduction of the disease state in the potential donor organ.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The histotripsy therapy system can include a robotic positioning system configured to move and translate an ultrasound transducer array through a treatment volume.

To provide systems and methods for histotripsy and immune therapies.SOLUTION: In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.SELECTED DRAWING: Figure 1

Histotripsy therapy systems configured for the treatment of tissue are provided, and can include any number of features. Provided herein are systems and methods that provide effective non-invasive and minimally invasive therapeutic, diagnostic, and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, effective histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A method for an ultrasound treatment using high intensity focused ultrasound (HIFU), the method including generating boiling histotripsy (BH) therapy ultrasound with a therapy transducer, applying the therapy ultrasound by directing a plurality of ultrasound pulses having ultrasound shock waves to a target tissue, generating at least one μm-scale vapor bubble at the target tissue within each pulse, growing the at least one vapor bubble to at least one mm-scale bubble, moving a focal point during each pulse of the plurality of pulses from a first region of the target tissue to a second region of the target tissue, and mechanically disintegrating the target tissue by interactions between the ultrasound shock waves with the at least one mm-scale bubble and bubble clouds, wherein the interactions take place within a duration of individual ultrasound pulses of the plurality of ultrasound pulses.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Histotripsy treatment involves sonicating a target region with a series of acoustic pulses, detecting ultrasonic reflected signals from the target region, controlling an ultrasonic transducer to deliver a sequence of acoustic pulses to the target region with sufficient amplitude to induce cavitation sufficient to mechanically rupture the tissue within the target region, receiving data characterizing the detected reflected signals, computationally estimating the level or location of acoustic activity or acoustic field distribution in the target region based on the data, and controlling the delivery of acoustic pulses by stopping, continuing, increasing, or decreasing the output level for acoustic pulse delivery based on multiple acoustic activity level estimates or acoustic field distribution estimates, thereby controlling tissue destruction in a target internal anatomical region.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Methods of biological tissue modification are also provided. The systems and methods disclosed here are uniquely different in that they aim to target, plan and treat target tissue, and selectively destroy and modify cellular architecture, but with specific intent and treatment parameters specialized for retaining specific target physical biological structures within the cell itself.

Methods, systems, and computer storage media for the improved treatment of biological tissue, such as skin, muscle, fat, nerves, or glands, or components thereof, are described herein. In some embodiments, a method of treating a patient's biological tissue comprises positioning an ultrasound pressure wave in a target volume of the region of biological tissue to form a cavitation bubble cloud in the target volume using the pressure wave, and maintaining the cavitation bubble cloud in the target volume for a time period sufficient to produce within the target volume. In some embodiments, the homogenate is fractionated within non-homogenized or healthy biological tissue in the region of biological tissue.

A system and method, including an ultrasound imaging transducer, an ultrasound therapy transducer, a robotic arm configured to orient the ultrasound imaging transducer and the ultrasound therapy transducer about a patient, a display connected to imaging transducer, and a memory, storing instructions that when executed by a processor receive ultrasound images from the imaging transducer, present ultrasound images, receive an input to alter a shape of a contour line, present the contour line, receive an input of a size of a margin around the treatment area, present the margin, determine end points at locations where X, Y, and Z axes bisect the contour line in an XZ plane and a YZ plane, drive the ultrasound therapy transducer to a location where a focal point of the ultrasound therapy transducer is at the end point, and determining whether a resistance to movement exceeds a threshold.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features such as planning and implementation of an adaptive distribution of cooling periods across a treatment volume of tissue given various treatment depths and voltages. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures for tissue cooling. Other embodiments are described herein.

Minimally invasive histotripsy systems and methods are provided. In some embodiments, a minimally invasive histotripsy device is inserted into a patient. The device can be inserted endoscopically through a natural orifice of the patient, or laparoscopically through an incision in the patient's skin. The minimally invasive histotripsy device can be advanced to the target tissue and acoustically coupled to the target tissue before applying histotripsy therapy to the target tissue. In some embodiments, the minimally invasive histotripsy device includes a transducer array with a focal length of approximately 10-40 mm, a diameter of less than 35 mm, and the ability to create a peak negative focal pressure of at least 20 MPa.

A histotripsy device includes a first arm, a second arm spaced apart from the first arm, and a first probe unit. The first probe unit is mounted to the first arm and positioned such that, with the first and second arms coupled to the cranium, the first probe unit is positioned over and in contact with one of a left and right temporal region of the cranium. The first probe unit has a first transducer array configured to emit focused radiation at an ultrasonic frequency or frequency range and a first transcranial doppler probe moveable relative to the first transducer array and configured to emit sound waves.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Additional embodiments herein provide coupling systems for histotripsy including various ultrasound coupling membranes configured to interface with any ultrasound medium container and / or ultrasound medium associated with a histotripsy procedure.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. Treatment planning systems are also provided for preparing and implementing a digital treatment plan. The treatment planning can include dividing a target tissue volume into a plurality of treatment locations, and controlling the speed, and pattern of movement between these tissue locations.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. The systems and methods herein are configured to measure and display forces acting upon the therapy treatment head during a procedure. In some aspects, buoyancy forces from the acoustic coupling medium are also accounted for.

A histotripsy device treating tissue with cavitating microbubbles produced by a high power therapy ultrasonic transducer provides an independently positionable ultrasound probe located and registered to the therapy ultrasonic transducer using ultrasonic ranging signals communicating through the patient. In one embodiment the independently positionable ultrasound probe is an intra-cavity probe.

Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P−) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.