The present invention provides an FD-MIMO multi-cell downlink interference coordination method. A multi-cell downlink transmission system is employed, adjacent sectors of adjacent cells form a coordination area, ad each base station employs one uniform planar array antenna. The method comprises the steps of: employing a large-scale fading factor to divide center users and edge users by each base station in the coordination area; for each edge user, employing statistical channel information to perform full cooperation interference coordination or partial cooperation interference coordination; based on a partial frequency multiplexing method, dividing service frequency bands of the center users and the edge users, and calculating the transmission power of each base station for the edge users; and calculating beam forming vectors for edge users by each cell, and employing the transmission power to perform precoding transmission. The method provided by the invention employs the channel statistical information to coordinate interference between the cells, is small in the required channel information amount, simple in transmission scheme implementation, little in feedback amount, high inrobustness, low in complexity and easy to implement, effectively improves the cell edge user service quality and is suitable for various classic wireless communication systems.