The invention discloses a compound herbicidal composition containing monopyrimsulfonate and its application. The active ingredients are monopyrimsulfonate and isoproturon. The binary herbicidal composition of the present invention is compounded by using monosulfanilate and isoproturon with different herbicidal spectrums and complementary advantages and disadvantages. The combined use of the two delays the generation of drug resistance of crops and has ideal application effects: killing It has the advantages of wide grass spectrum, quick effect, high efficiency, low toxicity, low residue, safety and environmental protection, which can reduce the dosage of pesticides, reduce pesticide residues, good environmental compatibility, and safety for humans and animals. It is a high-quality chemical herbicide for wheat crops. As the content of active ingredients is reduced, the pesticide residues are reduced on the premise of improving the efficacy of the pesticide, and the safety of wheat and subsequent crops is higher, and the possibility of residual poisoning of pesticides to humans and animals is avoided.