Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for synthesizing piperazine

A synthesis method and piperazine technology, applied in the field of chemical synthesis, can solve the problems of poor product selectivity, low target conversion rate, serious equipment corrosion, etc., and achieve the effects of low production cost, concise separation process, and low consumption of raw materials

Active Publication Date: 2007-08-29
ZHEJIANG XINHUA CHEM
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing synthetic method has poor product selectivity, low target conversion rate, many by-products, serious equipment corrosion, large one-time investment, heavy pollution, and high production cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1: This piperazine (C 4 h 10 N 2 ) synthesis method:

[0009] 1), using hydroxylamine as the raw material, water as the auxiliary agent, a solution of a certain concentration of hydroxylamine and water as the reaction solution, and Ni-Cu / γ-Al 2 o 3 - Diatomaceous earth is the catalyst; where Ni-Cu / γ-Al 2 o 3 -diatomaceous earth is catalyst: the gamma-Al that buys on the market 2 o 3 Add a certain amount of diatomaceous earth and mix evenly, extrude, dry, and roast to obtain strips of γ-Al with a diameter of 4 mm and a length of 3 to 7 mm. 2 o 3 - Diatomaceous earth carrier, the nitrates of Ni, Cu, Cr, Mn, Zn, Ru are made into a mixed solution in proportion, for γ-Al 2 o 3 - Diatomaceous earth carrier is impregnated, dried and put into muffle furnace for 24h roasting, the obtained content is Ni12.5%, Cu7.0%, Cr6.1%, Zn 5.0%, Mn 5.3%, Fe4.1%, and the rest is γ-Al 2 o 3 , Ni-Cu / γ-Al mixture of diatomaceous earth 2 o 3 - diatomaceous earth catalyst...

Embodiment 2

[0012] Example 2: According to the method described in Example 1, the content is Ni13.5%, Cu7.0%, Cr6.1%, Zn5.0%, Mn 5.3%, Fe4.1%, and the rest are γ-Al 2 o 3 , Ni-Cu / γ-Al mixture of diatomaceous earth 2 o 3 - diatomaceous earth catalyst. The catalyst number is A-2.

Embodiment 3

[0013] Example 3: According to the method described in Example 1, the content is Ni14.5%, Cu7.0%, Cr6.1%, Zn5.0%, Mn5.3%, Fe4.1%, and the rest are γ- al 2 o 3 , Ni-Cu / γ-Al mixture of diatomaceous earth 2 o 3 - diatomaceous earth catalyst. The catalyst number is A-3.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a synthesis method of piperazine. Said invention uses N-beta-hydroxyethylethylenediamine as raw material, uses water (or 1,4-dioxane, tetrahydrofuran, ethyl alcohol) as adjuvant and uses Ni-Cu / gamma-Al2O3-diatomite as catalyst whose composition includes Ni 1.0-25.0%, Cu 1.0-15.0%, Cr 1.0-15.0%, Mn 1.5-13.0%, Zn 1.0-11.0%, Fe 0-10.0%, and the rest is one of gamma-Al2O3 and diatomite or their mixture. Said reaction is implemented in vapor phase by adopting continuous flow process. Besides, said invention also provides its operation condition.

Description

technical field [0001] The invention relates to a chemical synthesis method, in particular to a synthesis method of piperazine using N-β-hydroxyethylethylenediamine as a raw material. Background technique [0002] Piperazine (alias: bis-dimethylamine, tetramethyldiamine, p-diazepine, hexahydropyrazine, piperazine, piperazine, etc.) is an important pharmaceutical intermediate and fine chemical raw material, piperazine and The salts formed by the reaction of organic acids or inorganic acids are widely used as insect repellants for humans and animals. Organic acid salts are mainly used for human bodies, while inorganic acids are mostly used as veterinary drugs. The main use of piperazine is as a pharmaceutical intermediate for the production of norfloxacin, pyrazinoic acid, anthelmintics fosperidic acid, azine citrate, and fluphenazine, chlorpheniramine, rifampicin and other drugs. In addition, piperazine can also be used as a raw material for rubber vulcanizing agents, antiox...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D295/027C07D295/023
Inventor 胡健陈国建兰昭洪
Owner ZHEJIANG XINHUA CHEM