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Ergosterol preparation method

A technology for ergosterol and ethanol, applied in the field of preparation of ergosterol, can solve the problems of low extraction rate of ergosterol, unstable saponification, long time, etc., and achieves high saponification efficiency, simplified refining and filtration process, and high recovery rate. Effect

Inactive Publication Date: 2007-09-26
MENGYONG MEDICINE IND
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The preparation method of existing ergosterol is atmospheric pressure saponification more than 12 hours, and the shortcoming that it exists is that the time long saponification is not stable enough, and the extraction rate of ergosterol is low

Method used

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  • Ergosterol preparation method

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Effect test

Embodiment 1

[0023] raw material:

[0024] 1. Yeast powder is medicinal yeast with a total sterol content of more than 10‰.

[0025] 2. Ethanol is used for medicine and contains C 2 h 5 OH95% or more, aldehyde≤0.0030%.

[0026] 3. Toluene is industrially pure, colorless, transparent, volatile and flammable liquid, can be mixed with alcohol, aldehyde, chloroform, acetone, carbon disulfide and glacial acetic acid, etc., slightly soluble in water. The specific gravity is 0.866, the flash point is 6-10°C, the boiling point is 110.8°C, and the melting point is -9.5°C. Its steam can form an explosive mixture with air, and its explosion limit is 1.27-7% (volume);

[0027] 4. Sodium chloride NaCl;

[0028] 5. Sodium hydroxide NaOH;

[0029] 6. Activated carbon is 767 type, for injection;

[0030] Process steps:

[0031] 1) Saponification: use dry yeast powder, add sodium hydroxide according to the ratio of dry yeast powder: sodium hydroxide = 1: 0.5, add dry yeast powder: sodium chloride =...

Embodiment 2

[0040] Raw material is identical with embodiment 1.

[0041] Process steps:

[0042] 1) Saponification: use dry yeast powder, add sodium hydroxide according to the ratio of dry yeast powder: sodium hydroxide = 1: 0.7, and add in the ratio of dry yeast powder: sodium chloride = 1: 0.3 according to 500 kg per pot Sodium chloride, the saponification temperature is 118-120°C, and the saponification time is 4-6 hours;

[0043] 2) Add toluene for extraction: add 1500 liters of toluene into the saponification pot three times, 600 liters for the first time, 500 liters for the second time, 400 liters for the third time, the temperature is 60-80 °C, and the standing time is 1 hour / every time;

[0044] 3) Extraction of toluene ergosterol liquid: in the saponification pot, extract the clear layered toluene ergosterol liquid into the washing tank, wash with boiling water three times, the amount of boiling water each time is 200-300 liters, and then transfer to Concentrate in the concen...

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Abstract

The invention relates to a process for preparing ergosterol, which comprises the steps of (1) saponification, (2) charging toluene for extraction, (3) extracting toluene ergosterol solution, (4) a first concentration, (5) a second concentration, (6) hot cleaning, (7) refining.

Description

technical field [0001] The present invention relates to the preparation method of ergosterol. Background technique [0002] Ergosterol (Ergosterl), also known as ergosterol. Its formula C 28 h 44 O and VD 2 The molecular formula is the same, but the structural formula is different, its molecular weight is 396.66, and the structural formula is CH 3 . [0003] The oxygen atom in the ergosterol molecule is inside the hydroxyl group, so ergosterol is a high molecular weight alcohol, which can form esters with acids. The molecule of ergosterol is made up of four rings. On the first ring, there is an alcohol group (hydroxyl group), on the second ring there are two conjugated double bonds, and the fourth ring is connected with a side chain composed of 9 carbon atoms. Ergosterol is an unsaturated compound (it has three double bonds), so when it encounters light and oxygen in the air, it will be oxidized and deteriorate even at normal temperature. Its properties are colorless...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P33/00
Inventor 李杨发周学林
Owner MENGYONG MEDICINE IND
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