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Oral disintegrated Anfenmame tablet for treating children's cold and its prepn

A technology of orally disintegrating tablets and paracetamol, which is applied to medical preparations containing active ingredients, anti-infectives, and pharmaceutical formulas, can solve problems affecting children's physical and mental health, improper medications, and delayed treatment. Good flow-aid effect, strong capillary action, and the effect of improving fluidity

Inactive Publication Date: 2009-01-07
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it often leads to improper medication, delayed treatment, or even medical accidents, which affect the physical and mental health of children.

Method used

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  • Oral disintegrated Anfenmame tablet for treating children's cold and its prepn
  • Oral disintegrated Anfenmame tablet for treating children's cold and its prepn
  • Oral disintegrated Anfenmame tablet for treating children's cold and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 principal agent powder coating granules

[0040] With ethanol as solvent, add No. IV acrylic resin, with talcum powder as anti-adhesive agent, coating liquid prescription is by weight:

[0041] Acrylic No. IV 10%

[0042] Ethanol 89%

[0043] Talc 1%

[0044]Its preparation process is as follows: the crude drug is mechanically pulverized and passed through a 100-mesh sieve for subsequent use; take an appropriate amount (according to the above weight ratio) of dehydrated alcohol, and add No. IV acrylic resin while stirring until completely dissolved; weigh the talc of the prescription amount powder, add it to No. IV acrylic resin ethanol solution, and keep stirring; add the drug into the fluidized bed coating machine, the optimum air inlet temperature is 30°C, and coat the drug according to the operation requirements of the equipment until the specified coating Coating weight gain (paracetamol coating weight gain should reach about 25%;...

Embodiment 2

[0047] Embodiment 2 The prescription of paracetamol coated powder, pseudoephedrine hydrochloride coated powder, and dextromethorphan hydrobromide coated powder as the main ingredient, and other ingredients as auxiliary materials to prepare orally disintegrating tablets of acetaminophen is:

[0048] Acetaminophen Coated Powder with Acetaminophen 80g

[0049] Pseudoephedrine Hydrochloride Coated Powder Contains Pseudoephedrine Hydrochloride 7.5g

[0050] Dextromethorphan Hydrobromide Coated Powder Contains Dextromethorphan Hydrobromide 2.5g

[0051] Lactose 150g

[0052] Starch 27g

[0053] Crospovidone 30g

[0054] Appropriate amount of strawberry essence

[0055] Aspartame 15g

[0056] Sodium chloride 6g

[0057] Magnesium Stearate 3g

[0058] Micronized silica gel 3g

[0059]

[0060] 1000 pieces

[0061] Tablet pressing adopts the pharmaceutical equipment commonly used for ordi...

Embodiment 3

[0064] Acetaminophen Coated Powder with Acetaminophen 80g

[0065] Pseudoephedrine Hydrochloride Coated Powder Contains Pseudoephedrine Hydrochloride 7.5g

[0066] Dextromethorphan Hydrobromide Coated Powder Contains Dextromethorphan Hydrobromide 2.5g

[0067] Mannitol 300g

[0068] Microcrystalline Cellulose 10g

[0069] Low-substituted hydroxypropyl cellulose 50g

[0070] Flavor Appropriate amount

[0071] Aspartame 15g

[0072] Magnesium Stearate 3g

[0073] Micronized silica gel 3g

[0074]

[0075] 1000 pieces

[0076] Tablet compression can adopt direct compression method, and its specific preparation method is as follows: paracetamol, pseudoephedrine hydrochloride, dextromethorphan hydrobromide coating powder are respectively passed through 80 mesh sieves, then add the prescription amount passed through 100 mesh sieves For other auxiliary materials other than lubric...

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Abstract

The oral disintegrated Anfenmame tablet includes active components paracetamol, pseudoephedrine hydrochloride and dextromethorphan hydrobromide as well as stuffing, disintegrating agent, corrective, lubricant, flow assistant and other supplementary material. The oral disintegrated Anfenmame tablet has main medicine materials coated to mask bad taste, can disintegrate in oral cavity and is especially suitable for children to take for treating cold.

Description

technical field [0001] The invention relates to a compound cold medicine composed of acetaminophen, pseudoephedrine hydrochloride and dextromethorphan hydrobromide, which can be rapidly disintegrated in the oral cavity and a preparation method thereof. Background technique [0002] The common symptoms of a cold are headache, fever, nasal congestion, runny nose, and body aches. It is generally believed that the common cold is caused by rhinovirus. Since there is no specific medicine for the virus at present, symptomatic treatment is mainly used. There are many kinds of compound preparations used to prevent and treat colds on the market. From the perspective of the main ingredients, the commonly used drugs are mainly antiallergic drugs, drugs for reducing nasal mucosal congestion and edema, and antipyretic and analgesic drugs. The medicine contains antitussive drugs, chlorpheniramine (chlorpheniramine) is often used as an antiallergic drug, pseudoephedrine is often used as a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/02A61K31/485A61K31/137A61P31/00A61P31/12A61P29/00A61P11/00
Inventor 肖进迈邓杰肖波冯金华
Owner CHONGQING PHARMA RES INST