Gel for removing ocular by ice pearl and its preparation

An ophthalmic gel and preparation technology, which is applied to the field of Bingzhen ophthalmic gel preparation and preparation thereof, can solve the problems of short drug retention time, small drug absorption amount, influence on drug efficacy and the like, and achieve prolonging drug action time. , less frequent use of drugs, and the effect of increasing the efficacy of the drug

Active Publication Date: 2009-01-21
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the eye drops of this invention have certain irritation, short residence time of the medicine in the eye, and small amount of medicine absorption, thereby affecting the curative effect of the medicine. Therefore, the number and frequency of eyedrops during use are relatively high, which brings great inconvenience to the use of patients.

Method used

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  • Gel for removing ocular by ice pearl and its preparation
  • Gel for removing ocular by ice pearl and its preparation
  • Gel for removing ocular by ice pearl and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Pearl layer powder 350g

[0033] Zinc gluconate 4.18g

[0034] β-carotene 0.003g

[0035] Vitamin E 1g

[0036] borneol 0.6g

[0037] Carbomer 941 10g

[0038] Tween 80 2g

[0039] Benzalkonium Chloride 1g

[0040]

[0041] Borax 3g

[0042] Glycerol 15.5g

[0043]

[0044] Add water for injection to 1000ml

[0045]Add pearl layer powder with water for injection, stir well, boil, continue to stir for 48 hours, filter and concentrate the filtrate, add 50% of the prescription amount of benzalkonium chloride as a bacteriostatic agent, dissolve evenly to obtain solution A, and let it cool for later use; Dissolve Carbomer 941 in water for injection, heat up and dissolve under stirring to obtain solution B; add zinc gluconate to solution A to dissolve, then add borax and glycerin, stir to dissolve, add it to solution B, and boil and filter , to obtain solution C; take another water for injection, add borneol, β-carotene, vitamin E, Tw...

Embodiment 2

[0047] Pearl layer powder 350g

[0048] Zinc gluconate 4.18g

[0049] β-carotene 0.003g

[0050] Vitamin E 1g

[0051] borneol 0.6g

[0052] Polyvinyl alcohol 20g

[0053] Tween 80 2g

[0054] Benzalkonium Bromide 1g

[0055] Sodium citrate 3g

[0056] Sodium chloride 6.8g

[0057]

[0058] Add water for injection to 1000ml

[0059] Add pearl layer powder with water for injection, stir well, boil, continue to stir for 48 hours, filter, concentrate the filtrate to an appropriate amount, add 50% of the prescription amount of benzalkonium bromide as a bacteriostatic agent, dissolve evenly to obtain solution A, let it cool for later use Dissolve polyvinyl alcohol in water for injection, heat up and dissolve under stirring to obtain solution B; add zinc gluconate to solution A for dissolution, then add sodium citrate and sodium chloride, stir and dissolve, then add it to solution B , and boiled and filtered to obtain solution C; take another appropria...

Embodiment 3

[0061] Pearl layer powder 350g

[0062] Zinc gluconate 4.18g

[0063] β-carotene 0.003g

[0064] Vitamin E 1g

[0065] borneol 0.6g

[0066] Carbomer 940 15g

[0067] Tween 80 2g

[0068] Benzalkonium Bromide 1g

[0069] Triethanolamine 18g

[0070] Glucose 38g

[0071]

[0072] Add water for injection to 1000ml

[0073] Add pearl layer powder and water for injection, stir well, boil, continue to stir for 48 hours, filter, concentrate the filtrate to an appropriate amount, add 50% of the prescription amount of benzalkonium bromide, dissolve evenly to obtain solution A, let it cool for later use; take another injection Dissolve Carbomer 940 in water, add triethanolamine, heat up and dissolve under stirring to obtain solution B; add zinc gluconate to solution A to dissolve, add glucose, stir to dissolve, add it to solution B, and boil and filter to obtain solution C; Take another appropriate amount of water for injection, add borneol, β-carotene, vi...

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PUM

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Abstract

A medical gel for preventing and treating cataract contains the hydrolytic liquid of pearl powder, borneol, Zn, beta-carotene, VE, gel matrix and pharmacologically acceptable carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a medicine for treating eye diseases, in particular to a Bingzhen gel preparation for removing nebula and a preparation method thereof. Background technique [0002] Cataract is the main cause of blindness at present. According to the statistics of the International Health Organization, 40% of the blind people in the world are caused by cataract. The etiology of cataract has not yet been definitively concluded, it is generally believed that: [0003] (1) Excessive exposure to radiation; (2) Drug or chemical poisoning; (3) Metabolic diseases. Cataract patients are accompanied by various biochemical changes in the lens, such as electrolyte imbalance, reduction of amino acids, vitamins and reducing substances, reduction of ATP concentration, accelerated lipid peroxidation, and crystal protein aggregation. At present, the treatment of cataract is mainly divided into the following categories: (1) drugs that prevent the formation o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/56A61K9/00A61K47/34A61P27/12A61K31/045A61K33/30A61K31/355A61K31/557A61K35/618A61K47/10
Inventor 耿海明周建明杨波穆惠芳杨若
Owner 湖北远大天天明制药有限公司
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