Biological dressing and its preparing method

A technology of biological dressings and porous materials, applied in medical science, bandages, absorbent pads, etc., can solve the problems of insufficient softness, air permeability and effusion removal function, affecting biocompatibility and therapeutic effect, and lack of coverage, etc. Achieve the effect of good air permeability, scientific and reasonable preparation method, and improved softness

Inactive Publication Date: 2009-04-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dressing is not spongy, so there are deficiencies in softness, breathability, and fluid drainage
The Chinese patent application with the application number 00102103.6 mentions that the use of porous silk fibroin material can improve the softness and the function of removing fluid accumulation, but it needs to add other compounds, and there is no reinforcement layer, which will affect the silk fibroin biological dressing to play its natural biological phase. Capacitance and healing effect, and insufficient strength
At present, in the prior art, there is no film covering the surface of biological dressings to facilitate the regulation of wound humidity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Add 5% solution volume percentage of curing catalyst ethylene glycol diglycidyl ether into the silk fibroin protein aqueous solution with a mass fraction of 6%, stir and mix evenly, add the mixed solution into the mold in a thin layer, at -5???0~ Freeze at -2°C. In this embodiment, freezing at -20° C. for 3 hours is adopted. Take out the mold and add distilled water to the mold to thaw. Soak the thawed material in distilled water for 3 days, changing the water several times a day to remove the solidification catalyst and free silk fibroin. After draining the water to a certain water content, sterilize and pack.

[0025] The biological dressing manufactured in this example is made of a single porous silk fibroin sponge. Due to the limited tensile breaking strength, this product is mainly suitable for small area wound treatment.

[0026] The internal average pore diameter of the biological dressing manufactured in this embodiment: 80-200 μm; tensile breaking strength:...

Embodiment 2

[0028] Add 3% solution volume percentage of curing catalyst polypropylene glycol diglycidyl ether to the silk fibroin protein aqueous solution with a mass fraction of 4%. Lay a polyamide mesh reinforcing layer on the bottom of the mold, add a thin layer of the solution into the mold, and freeze at -50 to -2°C. In this embodiment, freezing is carried out at -30° C. for 2 hours. Take out the mold and thaw at natural temperature to loosen the added material and the mold. You can also continue to add distilled water, immerse the material in distilled water, and place the mold at -30°C for 2 hours to freeze again. The steps of freezing and thawing are repeated. Soak the thawed material in distilled water for 3 days, changing the water several times a day to remove the solidification catalyst and free silk fibroin. After draining the water to a certain water content, sterilize and pack.

[0029]The biological dressing manufactured in this embodiment is composed of silk fibroin s...

Embodiment 3

[0032] Adding 5% solution volume percentage of curing catalyst diglycidyl dicarboxylate to the silk fibroin protein aqueous solution with a mass fraction of 5%. Lay an elastic polyurethane mesh reinforcing layer on the bottom of the mold, add a thin layer of the solution into the mold, and freeze at -50 to -2°C. In this embodiment, freezing at -20° C. for 4 hours is adopted. Take out the mold and allow the material to thaw at natural temperature. Soak the thawed material in distilled water for 3 days, change the water several times a day, remove the curing catalyst and free silk fibroin, drain the water to a certain water content, stick a porous silicone rubber film, sterilize, and pack.

[0033] The pore diameter and pore distance of the porous polymer membrane can be determined according to the requirements of actual use. Generally, the pore diameter is 0.5-3mm, and the pore distance is 3-20mm.

[0034] The porous polymer film can be individually packaged and sterilized, a...

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Abstract

The invention discloses a biological dressing and making method of large-area skin defection therapy, which is characterized by the following: extracting silk protein from natural silk as the principal raw material; containing silk sponge cellular material single or composite with fabric netted reinforcing layer and perforated macromolecular film on the coverage of cellular material or reinforcing layer. The biological dressing provides good biological compatibility, softness-toughness, permeability of therapy medicine, strength and modulation of wound moisture, which is obvious to accelerate wound assimilation and easy to operate.

Description

technical field [0001] The invention relates to a biological dressing and a preparation method thereof, in particular to a biological dressing, which is a medical material made of biological materials and widely used for treating large-area skin defects, and a preparation method thereof. Background technique [0002] There are a large number of patients with skin defects in my country and the world every year, mainly patients with safety accidents, burns and patients with large area skin ulcers caused by diseases. With the development of chemical industry and modern industry, modern weapons and frequent wars, the number of burn patients remains high every year; with the rapid increase in the proportion of the elderly population and the deterioration of the environment, patients with large areas of skin ulcers caused by diabetes and other diseases are increasing rapidly all over the world. increase. Therefore, the demand for biological dressings is increasing day by day. Th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/00A61L15/00A61L15/32
Inventor 闵思佳吴豪翔朱良均
Owner ZHEJIANG UNIV
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