Recombination newcastle disease LaSota weak virus vaccine for expressing poultry influenza virus H5 sub type HA protein

An avian influenza virus, attenuated vaccine technology, applied in the direction of virus, antiviral agent, virus antigen components, etc., can solve the problem of not achieving widespread application
CN100487119CActive Publication Date: 2009-05-13HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2009-05-13

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Abstract

Recombinant Newcastle disease LaSota low virulent vaccine strains expressing wild or mutant avian influenza virus H5 subtype HA protein. Especially, the recombinant Newcastle disease LaSota low virulent vaccine strains are rL-QHwH5 and rL-QHmH5. The preparation process of the recombinant Newcastle disease LaSota low virulent vaccine strain and the application of the recombinant Newcastle disease LaSota low virulent vaccine strain in preparing vaccine for preventing avian influenza.
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Description

technical field

[0001] The present invention relates to the field of recombinant virus vaccines, more specifically, the present invention relates to a recombinant Newcastle disease LaSota attenuated vaccine strain expressing a gene encoding wild-type or mutant avian influenza virus H5 subtype hemagglutinin (HA) protein, more specifically The recombinant Newcastle disease LaSota attenuated vaccine strains are rL-QHwH5 and rL-QHmH5. The invention also discloses a method for preparing the recombinant Newcastle disease LaSota attenuated vaccine strain and the application of the recombinant Newcastle disease LaSota attenuated vaccine strain in preparing vaccines for preventing bird flu. Background technique

[0002] Newcastle disease virus (NDV) is a non-segmented single-stranded negative-sense RNA virus. As an important member and model virus of the Paramyxoviridae family, it has been deeply studied. Recombinant NDV has extraordinary advantages as a live virus vaccine carrier: ...

Claims

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