Icy seven drop pills and its preparation method

A technology of seven drop pills and drop pills, which is applied in the field of medicine for treating cardiovascular and cerebrovascular diseases and its preparation, can solve the problems of low natural degree of drop pill auxiliary materials, low natural degree, unfavorable traditional Chinese medicine drop pill preparations, etc., and achieve reduction Drug irritating odor, improvement of oral pH, and the effect of improving oral odor

Inactive Publication Date: 2009-07-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are the key to affect the preparation of dripping pills
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market,

Method used

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  • Icy seven drop pills and its preparation method
  • Icy seven drop pills and its preparation method
  • Icy seven drop pills and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] (a): Take 330g of notoginseng, 3.3g of borneol, 12g of xylitol, and 3g of xanthan gum for later use;

[0071] (b): Take notoginseng and add water to decoct 5 times, combine the decoction, filter, concentrate the filtrate, add 2 times the amount of 90% ethanol, let it stand for 20 hours, filter, recover the ethanol, and concentrate the filtrate until it is at 50°C , a thick paste (1) with a relative density of 1.15 to 1.25;

[0072] (c): Dissolve borneol in an appropriate amount of ethanol to obtain solution (2); add (1) (2) into the xylitol and starch mixture melted in a water bath, stir evenly, keep warm, and drop at a temperature of 55-75°C The caliber of the dropper is 1.30-4.0 mm, drop at a rate of 30-60 drops per minute, drop into methyl silicone oil, and make 1000 pills. After forming, take out the pills, and dry the surface of the dripping pills with absorbent paper , that is.

Embodiment 2

[0074] (a): Take 20g of notoginseng, 1.5g of borneol, 83g of lactitol, and 17g of starch for later use;

[0075] (b): Take Panax notoginseng and add water to decoct twice, combine the decoction, filter, concentrate the filtrate, add 4 times the amount of 85-95% ethanol, let stand for 36 hours, filter, recover ethanol, and concentrate the filtrate to 70-95% Clear paste (1) with a relative density of 1.10-1.25 at 80°C;

[0076] (c): Dissolve borneol in an appropriate amount of ethanol to obtain solution (2); add (1) (2) into the mixture of lactitol and starch melted in a water bath, stir evenly, keep warm, and store at a temperature of 65-95°C Dropping, the diameter of the dropper is 1.10-3.0 mm, dripping at a speed of 20-50 drops per minute, dropping into vegetable oil, and making 1000 dropping pills, after forming, take out the pills, and dry the dropping pills with absorbent paper Surface, that is.

Embodiment 3

[0078] (a): Take 15g of notoginseng, 0.8g of borneol, 37.5g of xylitol, and 12.5g of gum arabic for later use;

[0079] (b): Take notoginseng and add water to decoct 3 times, combine the decoction, filter, concentrate the filtrate, add 4 times the amount of 85-90% ethanol, let it stand for 18 hours, filter, recover the ethanol, and concentrate the filtrate to 40-90% A thick paste (1) with a relative density of 1.05-1.15 at 50°C;

[0080] (c): Dissolve borneol in an appropriate amount of ethanol to obtain solution (2); add (1) (2) into the mixture of xylitol and gum arabic, mix thoroughly, heat and melt the mixture at 50-95°C, and stir evenly , the stirring time is 10-30 minutes, keep warm, drip at a temperature of 60-85 °C, the diameter of the dropper is 1.1-3.5 mm, drop at a speed of 50-60 drops per minute, drop into methyl silicone oil, and prepare Make 1000 dropping pills, after forming, take out the pills, wipe dry the surface of the dropping pills with absorbent paper, a...

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PUM

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Abstract

The invention provides a medicine for treating coronary heart disease and angina. The disadvantage is that it is a pharmaceutical preparation with a higher degree of naturalness, stronger safety, and lower toxic and side effects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine for treating cardiovascular and cerebrovascular diseases made from traditional Chinese medicines and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary heart disease is the abbreviation of coronary heart disease. It is a disease with high morbidity and mortality and seriously endangers the health of human beings, so it is called "the first killer of human beings". Angina pectoris is a clinical syndrome caused by coronary artery blood supply insufficiency, myocardial acute, transient ischemia and hypoxia. It often occurs when you are tired, full of food, cold and emotional, and the...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/045A61K9/20A61P9/00A61P9/10
Inventor 李永强陈建明祝国光郑永锋朱永宏李旭章顺楠刘金平叶正良魏峰
Owner TIANJIN TASLY PHARMA CO LTD
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