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44results about How to "To achieve the purpose of healing" patented technology

Anti-CD19 full humanized antibody or antibody segment as well as method and application thereof

The invention discloses an anti-CD19 full humanized antibody or antibody segment as well as a method and an application thereof. The antibody or the antibody segment contains a heavy chain and a lightchain, wherein the heavy chain and the light chain comprise variable regions; the variable regions comprise complementary determining regions; the complementary determining regions CDR1, CDR2 and CDR3 of the heavy chain are separately represented by HCDR1, HCDR2 and HCDR3; the complementary determining regions CDR1, CDR2 and CDR3 of the light chain are separately represented by LCDR1, LCDR2 and LCDR3; the amino acid sequence of the HCDR1 comprises SED ID NO: 3; the amino acid sequence of the HCDR2 comprises SEQ ID NO: 4; the amino acid sequence of the HCDR3 comprises SEQ ID NO: 5; the amino acid sequence of the LCDR1 comprises SEQ ID NO: 6; and the amino acid sequence of the LCDR2 comprises SEQ ID NO: 7. The antibody or the antibody segment can be combined with a humanized CD19 protein with high specificity, and by means of engineered expression integration by means of a chimeric antigen receptor cell technology in a cell T, the obtained chimeric antigen receptor cell T can be used for treating hematological cancers related to expression of CD19.
Owner:CHANGZHOU VELOX PHARMA SCI & TECH CO LTD

Combined Chinese and western medicine sustained-release agent for preventing and treating rabbit coccidiosis and preparation method thereof

The invention discloses a retarder combining Chinese medicines and western medicines and used for preventing and curing the rabbit coccidiosis and a preparation method thereof, pertaining to the technical field of prevention and cure with the drug of poultry and livestock parasite. The retarder comprises ingredients with portions by weight: 2 to 5 portions of antifeverile dichroa root, 3 to 6 portions of abrotanum, 2 to 5 portions of sophora flavescens, 1 to 3 portions of pulsatilla chinensis, 1 to 3 portions of radix bupleuri, 1 to 3 portions of rhizoma imperatae, 1 to 3 portions of liquoric root, 0.01 to 0.05 portions of diclazuril, 8 to 10 portions of porous starch and 0.001 to 0.003 portions of chitosan. The ingredients are prepared by the steps of soaking in ethanol and Soxhlet extraction, followed by soaking in water and Soxhlet extraction, mixing, absorption and combination of extract and diclazuril as well as porous starch and chitosan, and regulation of medicinal powder quality, etc. The results from the experiments show that the egg reduction rate for the rabbit coccidiosis is 99.2 percent; in addition, the retarder of the invention is mainly applied to the prevention and cure of the rabbit coccidiosis.
Owner:HEZHOU UNIV

Pure traditional Chinese medicine composition capable of effectively preventing and controlling poultry enterovirus syndrome and preparation method and use method of composition

The invention aims to provide a pure traditional Chinese medicine composition capable of effectively preventing and controlling poultry enterovirus syndrome and a preparation method and a use method of the composition. The pure traditional Chinese medicine composition consists of the following raw materials in parts by weight: 10-20 parts of radix pulsatillae, 10-20 parts of herba andrographitis,10-20 parts of herba pogostemonis, 10-20 parts of radix sophorae flavescentis, 10-15 parts of cortex phellodendri, 10-15 parts of rhizoma coptidis and 10-20 parts of talcum. The preparation method includes the following steps: A. removing impurities from the raw materials for later use; B. respectively adding the raw material medicines after impurity removal into a pulverizer for pulverization toobtain raw material medicine powder; C. uniformly mixing the raw material medicine powder according to the parts by weight to obtain a pure traditional Chinese medicine composition. The use method ofthe pure traditional Chinese medicine composition for preventing and controlling the poultry enterovirus syndrome includes mixing the prepared pure traditional Chinese medicine composition into feed according to the proportion of 0.2-0.3 % in parts by weight or mixing the composition into drinking water according to the proportion of 0.1-0.2 % in parts by weight for feeding.
Owner:GUANGDONG GAOSHAN ANIMAL MEDICINE

Traditional Chinese medicine chewable tablet for treating gastropathy and preparation method thereof

The invention discloses a traditional Chinese medicine chewable tablet for treating gastropathy and a preparation method thereof, relating to the field of traditional Chinese medicine for treating gastropathy. The invention aims at solving the problems of the current Danfu Weierkang granules, such as inconvenient taking, bad solubility and low absorption rate. The preparation method of the invention comprises the steps of: preparing 13 types of traditional Chinese medicines according to a particular proportion, for example, hoantchy root and radix paeoniae alba, and the like; decocting, filtering, concentrating and drying the medicines to fine powder; adding additives such as dextrin to prepare granules; drying the granules; adding magnesium stearate and tabletting to obtain the tablet. The traditional Chinese medicine chewable tablet for treating gastropathy has the advantages that the bioavailability is improved, the treatment effect is guaranteed, the treatment function of the medicine is effectively performed, and that the tablet is convenient to be taken by chewing under a waterless or water-lacking condition, so that the tablet is especially suitable for children and patients suffering from dysphagia. The invention is applied in the field of preparing traditional Chinese medicine for treating gastropathy.
Owner:哈药集团中药二厂

Traditional Chinese medicine composition for preventing avian enterovirus syndrome as well as preparation method and application of traditional Chinese medicine composition

InactiveCN106063913AInhibit apoptosisInhibit abnormal metabolic activityAntibacterial agentsDigestive systemProtozoaRemove blood
The invention provides a traditional Chinese medicine composition for preventing avian enterovirus syndrome. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 20 to 30 parts of cattail pollen, 15 to 25 parts of turmeric, 15 to 25 parts of peach kernel, 10 to 30 parts of radix paeoniae rubra, 10 to 30 parts of rhizoma alismatis, 10 to 30 parts of radix curcumae, 10 to 25 parts of fructus aurantii immaturus and 10 to 30 parts of bighead atractylodes rhizome. The invention further provides a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the efficacies of promoting blood circulation to remove blood stasis, and strengthening the spleen to regulate qi, and is capable of strengthening the intestinal mucosal barrier function, improving the intestinal micro-ecological internal environment, and effectively inhibiting abnormal metabolic activities of germs, fungi, protozoa and viruses, thereby being an effective traditional Chinese medicine preparation for preventing and treating the avian enterovirus syndrome.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS

A fully human antibody or antibody fragment against CD19 and its method and application

The present invention discloses an anti-CD19 fully human antibody or antibody fragment as well as methods and applications thereof. The antibody or antibody fragment comprises: a heavy chain and a light chain; the heavy chain and the light chain comprise a variable region, and the variable region comprises a complementary decision area. The complementarity determining regions CDR1, CDR2 and CDR3 of the heavy chain are represented by HCDR1, HCDR2 and HCDR3 respectively; the complementarity determining regions CDR1, CDR2 and CDR3 of the light chain are represented by LCDR1, LCDR2 and LCDR3 respectively; the amino acid sequence of HCDR1 includes SEQ ID NO: 3 The amino acid sequence of HCDR2 includes SEQ ID NO: 4; the amino acid sequence of HCDR3 includes SEQ ID NO: 5; the amino acid sequence of LCDR1 includes SEQ ID NO: 6; the amino acid sequence of LCDR2 includes DVS; the amino acid sequence of LCDR3 includes SEQ ID NO: 7. The antibody or antibody fragment of the present invention can bind to human CD19 protein with high specificity, and the chimeric antigen receptor T cell technology is used to engineer expression and integration in T cells, and the obtained chimeric antigen receptor T cells can be used for treatment Hematologic cancers associated with CD19 expression.
Owner:CHANGZHOU VELOX PHARMA SCI & TECH CO LTD

A biological enzyme drug line for treating cancer and rheumatic bone disease

InactiveCN106214228BCorrect ischemia and hypoxiaEnhanced supplyOrganic active ingredientsAntipyreticDiseaseHuman body
The invention relates to a novel therapy for treating rheumatoid bone diseases and advanced cancer pain by utilizing a biological needle and a biological enzyme medicated thread, and belongs to the technical field of pain treatment. The novel therapy comprises the following steps: selecting meridians and collaterals, acupuncture points and therapy points according to different disease symptoms, and marking by iodophor; preparing a needed biological needle; inserting the biological enzyme medicated thread from a needle head end hole of a trocar of the biological needle and pushing the biological enzyme medicated thread into the middle part of a protection sleeve of the trocar; dipping a needle tip of the trocar into medical liquid; combusting on an alcohol lamp for 1 to 2 seconds; then dipping in medical powder and continually combusting for 1 to 2 seconds; rapidly stabbing a combusted needle head into one therapy point; planting the biological enzyme medicated thread in the sleeve of the trocar into an acupuncture point of a human body by pushing a needle core through a pintle, and injecting a related hydro-acupuncture medicament for carrying out adjuvant therapy. The novel therapy provided by the invention is finished through utilizing needle stabbing and medicine administration on acupuncture points of diseases and pains, and the diseases and pains are radically removed; the pains of patients with cancer pains are rapidly alleviated and the life of the patients with the cancer pains can be properly prolonged, so that the novel therapy is good news for patients with the rheumatoid bone diseases and patients with advanced cancer.
Owner:徐风

Traditional Chinese medicine paste for treating lumbar muscle degeneration

The invention relates to traditional Chinese medicine paste for treating lumbar muscle degeneration and in particular relates to traditional Chinese medicine paste prepared by taking Chinese herbal medicines as raw materials. The preparation method comprises the following steps: grinding dried cacumen biotae, screening with a sieve of 60 meshes, extracting for 3 hours by using petroleum ether, filtering the extracting solution, performing vacuum drying to obtain dry extract, and grinding; drying the washed zaocys dhumnade, all-grass of carpet bugle, obscured homalomena rhizome and honeysuckle stem, grinding and uniformly mixing; adding the washed rhizoma cibotii, psammosilene tunicoides and eucommia ulmoides into a certain amount of 70 percent ethanol, heating and extracting for 4 hours, steaming for 3 hours by using steam, taking out the materials, drying in a constant temperature drying box at the temperature of 50 DEG C to obtain the dry extract, and grinding; grinding a certain amount of radix scrophulariae and teasel root, heating under normal pressure, extracting for 3 times, mixing the extracting solutions, filtering by virtue of 4-layer filter cloth (100 meshes), mixing the supernatant, concentrating, drying to obtain the dry extract, and grinding; and fully mixing the obtained components to prepare the paste, thereby obtaining the product. The traditional Chinese medicine paste is characterized by comprising the following raw materials in parts by weight: 220-260 parts of cacumen biotae, 140-170 parts of zaocys dhumnade, 200-240 parts of rhizoma cibotii, 100-130 parts of psammosilene tunicoides, 70-90 parts of sida szechuensis, 40-60 parts of obscured homalomena rhizome, 290-350 parts of radix scrophulariae, 250-280 parts of eucommia ulmoides, 120-160 parts of honeysuckle stem and 80-120 parts of teasel root.
Owner:WEIHAI NOVODA PHARMA GRP

A kind of traditional Chinese medicine preparation for treating viral conjunctivitis

The invention discloses a Chinese medicinal preparation for treating viral conjunctivitis, which consists of the following traditional Chinese medicine raw materials in part by weight: the rhizome of Chinese goldthread, lonicera flower, smoked plum, Chinese parsnip root, selfheal, fructus forsythiae, isatis root, folium isatidis, radix bupleuri, tribulus terrestris, periostracum cicada, dandelion, akebia stem, radices trichosanthis and radix scrophulariae. The Chinese medicinal preparation disclosed by the invention is prepared through syndrome differentiation of traditional Chinese medicine on the viral conjunctivitis and repeated clinical prescription compatibility; after a patient takes the Chinese medicinal preparation disclosed by the invention, yin and yang are balanced by invigorating qi and blood, dispelling wind and clearing heat, reinforcing immunity of the organism of a patient and regulating and nourishing to recover functions of liver, kidney, spleen and stomach so as to dissipate pathogenic qi, warm meridians, dilate vessels, improve local blood circulation, promote inflammation absorption, enable qi and blood to be sufficient, enable symptoms to be self-removed and heal the viral conjunctivitis. Moreover, the Chinese medicinal preparation disclosed by the invention does not generate drug resistance, has no toxic or side effects and has one course of treatment of 7 days; after the patient takes the Chinese medicinal preparation for one to two courses of treatment, the viral conjunctivitis can be cured; and the statistic data of clinically treating the viral conjunctivitis shows that the effective rate reaches over 98 percent.
Owner:董素美

Bony spur eliminating powder

The invention discloses bony spur eliminating powder and belongs to the technical field of medicines. The bony spur eliminating powder aims at solving the problems that the treatment effect is poor, symptoms are cured but diseases are not cured and the diseases of patients will relapse after being cured. The active ingredients of traditional Chinese medicines for the bony spur eliminating powder are prepared from, by weight, 27-33 parts of mountain morning glory roots, 2-5 parts of resina populi, 11-15 parts of processed monkshood, 11-15 parts of kusnezoff monkshood roots, 5-9 parts of radix cyathulae, 5-9 parts of cortex phellodendri, 7-11 parts of grass, 7-11 parts of rhizoma cibotii, 5-9 parts of rhizoma drynariae, 5-9 parts of radix angelicae pubescentis and 2-5 parts of licorice. The bony spur eliminating powder has the advantages that the efficacy of the bony spur eliminating powder can quickly penetrate into subcutaneous tissues, has the effects of dispelling wind, eliminating dampness, activating blood circulation to dissipate stasis, softening hardness to dissipate stagnation and relieving swelling and pain, has most remarkable treating effect on hyperostosis, especially on cervical vertebra hyperplasia, can relieve acute pain caused by vertebra lumbalis and hyperplasia of knee joints and finally achieves the cure purpose.
Owner:张杰
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