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Raman surface reinforced fiber-optic catheter sensor used for cancer diagnose

A surface-enhanced, fiber-optic catheter technology, applied in the field of medical instruments, can solve the problem that laser and Raman signals cannot penetrate deep body surfaces, and achieve the effect of surface-enhanced Raman scattering, large signal information, and effective excitation

Inactive Publication Date: 2009-09-23
SOUTHEAST UNIV
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Problems solved by technology

This method can well solve the problem that laser and Raman signals cannot penetrate deep body surface

Method used

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  • Raman surface reinforced fiber-optic catheter sensor used for cancer diagnose
  • Raman surface reinforced fiber-optic catheter sensor used for cancer diagnose
  • Raman surface reinforced fiber-optic catheter sensor used for cancer diagnose

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Embodiment Construction

[0043] A Raman surface-enhanced optical fiber catheter sensor for cancer diagnosis provided by the present invention will be described in detail below with reference to the accompanying drawings.

[0044] The invention provides a Raman surface-enhanced optical fiber catheter sensor for cancer detection, including: a medical catheter, an emission / reception grating optical fiber bundle, and a cancer-specific Raman enhanced detection platform. Through direct contact between this reaction platform and the human body environment, tumor-specific markers can be combined in real time, and at the same time, nano-silver and nano-patterned surfaces can be used to enhance the Raman signal and further transmit cancer information.

[0045] Medical catheters use polyurethane catheters or polytetrafluoroethylene or other medical catheters, among which polyurethane is widely used in clinical interventional therapy, has good biocompatibility and superior mechanical properties, and can enter the ...

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Abstract

The Raman surface-enhanced fiber optic catheter sensor for cancer diagnosis uses medical catheters as intervention materials, and combines catheters and optical fibers to introduce cancer-specific diagnostic sensors into the human body, directly detect Raman signals on tumor sites, and realize in vivo detection of cancer and diagnosis. The sensor includes: a medical catheter (11), an emission / reception grating optical fiber bundle (12), a cancer-specific Raman enhanced detection platform (15); wherein, the emission / reception grating optical fiber bundle (12) is located in the medical catheter (11) , the cancer-specific Raman-enhanced detection platform (15) is placed on the wedge-shaped polyurethane substrate (14) in the medical catheter (11), receives the light scattering signal fed back by the grating optical fiber bundle, and focuses the Raman at its head end through a microlens Mann scatters the signal, increasing its intensity. Signal acquisition is performed with a small or portable Raman spectrometer or a small fiber optic spectrometer in an in vitro detection device.

Description

technical field [0001] The invention relates to a Raman surface-enhanced fiber optic catheter sensor for cancer diagnosis, which realizes the technology of real-time detection of cancer in vivo by detecting Raman signals of tumor-specific molecules, and belongs to the technical field of medical instruments. Background technique [0002] Cancer is the greatest enemy of human health. Cancer can occur in almost all organs of the human body. About 6 million people in the world are killed by cancer every year. In my country, 1.6 million to 1.8 million people are diagnosed with cancer every year, and 1.3 million people die of cancer. The mortality rate is second only to coronary heart disease. On the other hand, almost all cancers are treatable if detected and diagnosed early, so early detection and diagnosis of cancer play an important role in clinical management. [0003] Raman spectroscopy is a non-destructive detection method based on the characteristics of the interaction be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61B19/00
CPCG01N21/658A61B5/0084G01N2021/656A61B5/0075
Inventor 顾宁江筱莉金永龙顾加雨
Owner SOUTHEAST UNIV
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