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Production of flax lignan

A technology of flax lignan and preparation process, which is applied to the preparation of sugar derivatives, sugar derivatives, sugar derivatives, etc., can solve the problems of high manufacturing cost, need for distillation and recovery, no technical problems, etc., and achieves shortening The effect of extraction man-hours, reduction of adsorption costs, and elimination of residual poisons

Inactive Publication Date: 2010-01-13
浙江瑞康生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the disadvantage is: the solvent after ultrafiltration still needs to be recovered by distillation without alkali treatment, and the resulting product is not high-quality SDG
no real technological breakthrough
[0010] The common defect of the three US patents is that the final purification step of the product uses expensive adsorbents
This is the same problem as my country's patent number 01120199.1, which leads to high manufacturing costs

Method used

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  • Production of flax lignan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] a. Extraction: get 200 grams of linseed meal, use 2000 milliliters of 70% ethanol aqueous solution (wherein containing sodium hydroxide 2%) as extraction solvent, 60 ℃ for 5 hours, emit liquid. Supplementary leaching solvent 1000 milliliters, 60 ℃ 3 hours, release liquid. Add hydrochloric acid to adjust the pH to neutral (6.5-7.5). At 60-90°C and under a negative pressure of 0.6-0.9 MPa, distill and recover ethanol to obtain 800 ml of alcohol-free extract.

[0040] b. Extraction: Add ethyl acetate twice the volume of the alcohol-free extract, stir and let stand to separate layers, and take the water phase. Add one-fold volume of ethyl acetate to the water phase, stir and let stand to separate the layers, and take the water phase. Obtain 800 ml of crude extract of lignans.

[0041] C. Column: Add the crude extract to a macroporous resin chromatography column (resin model XAD-7HP). After the addition, the column was rinsed with deionized water until the effluent was c...

Embodiment 2

[0044] a. Extraction: take 500 grams of linseed meal, 5000 milliliters of extraction solvent [80% n-propanol aqueous solution (containing 8% sodium hydroxide)], leaching at 65 ° C for 5 hours, and release the liquid; add 2000 milliliters of extraction solvent , 65°C for 3 hours, the liquid was released. Add 20% aqueous sulfuric acid to adjust the pH to neutral (6.5-7.5). At 60-90°C and under a negative pressure of 0.6-0.9 MPa, distill and recover propanol to obtain 2000 ml of alcohol-free extract.

[0045] b. Extraction: Add butyl acetate twice the volume of the alcohol-free extract, stir and let stand to separate layers, and take the water phase. Add double the volume of butyl acetate to the water phase, stir and let stand to separate the layers, and take the water phase. Obtain lignans crude extract 2000 milliliters.

[0046] c. Column passing: the crude extract is added to a macroporous resin chromatography column (resin model SP70). After the addition, the column was w...

Embodiment 3

[0049] a. Extraction: Take 1000 grams of linseed meal, 10000 milliliters of extraction solvent [50% aqueous methanol solution (wherein containing potassium hydroxide 3%)] 10000 milliliters, leaching at 60 ℃ for 5 hours, release liquid; ℃ for 3 hours, the liquid was released. Add glacial acetic acid to adjust the pH to neutral (6.5-7.5). At 60-90°C, under a negative pressure of 0.6-0.9 MPa, distill and recover methanol to obtain 4500 ml of alcohol-free extract.

[0050] b. Extraction: Add diethyl ether to six times the volume of the alcohol-free extract, stir and let stand to separate layers, and take the water phase. Add three times the volume of diethyl ether to the water phase, stir and leave to separate layers, and take the water phase. Obtain lignans crude extract 4500 milliliters.

[0051]c. Column passing: the crude extract is added to a macroporous resin chromatography column (resin model XAD761). After the addition, the column was washed with 10% aqueous ethanol un...

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Abstract

Production of flax lignose is carried out by taking flax cake as raw material, leaching by alcohol containing alkali, neutralizing, concentrating to obtain non-alcohol leaching liquor, extracting with ethyl acetate as solvent, adsorbing by porous resin chromatograph column and drying. It's cheap and convenient and better quality.

Description

technical field [0001] The invention relates to a process for producing flax lignans, in particular to a method for extracting flax lignans from flax cake or flax meal. Background technique [0002] Lignans are a large class of natural compounds in plants. In Western countries, lignan-containing foods represented by flaxseed powder have been on the market for many years and have become regular health products for middle-aged and elderly people. Recently, high-purity, standardized lignan extract products that meet the curative effect requirements have also been launched, and can be widely used in capsules, compressed tablets, and various breakfast and fast food additives. [0003] A small number of reports on the study of flax lignans were published in China at the beginning of this century. The patent number is ZL01120199.1, titled "Method for Extracting, Separating and Purifying Flax Lignans from Flax Cake", which discloses a method of extracting with alcohol and water, h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H1/08
Inventor 胡云峰朱升邓华陈跃军
Owner 浙江瑞康生物技术有限公司
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